从头合成

MPA的主要作用机理是抑制次黄嘌呤单核苷酸脱氢酶（IMPDH），该酶是鸟嘌呤核苷酸从头合成途径的限速酶。IMPDH受抑导致鸟嘌呤核苷酸生成减少，进而DNA、RNA合成受阻。

The main mechanism of MPA is that it inhibits IMPDH which is the rate-limiting enzyme in de novo synthesis of guanosine nucleotides .

在动物体内，IMP从头合成共涉及十步反应，其中腺苷琥珀酸裂解酶（ADSL，adenylosuccinatelyase）是催化第八步反应的酶，也是合成IMP过程中的关键酶之一。

IMP de novo synthesis was involved in ten step reactions in animal . Adenylosuccinate lyase ( ADSL ), which is a key enzyme in the process of synthesis of IMP , catalyzed reaction of the eighth step .

T、B淋巴细胞比其他类型细胞更多地依赖从头合成途径。

T-and B-lymphocytes are more dependent on this pathway than other cell types .

在类固醇激素的合成过程中，胆固醇由线粒体外膜到内膜转运的过程是类固醇激素合成的限速步骤，这一步骤必需有类固醇激素灵敏调节蛋白（StAR）的从头合成才能完成。

The translocation of cholesterol from the out to the inner mitochondrial membrane is a rate-limiting step that requires steroidogenic acute regulator protein ( StAR ) synthesis de novo in steroidogenesis .

炉排炉飞灰中二恶英主要是通过前驱物生成，而流化床炉飞灰中二恶英则主要通过denovo（从头合成）反应途径生成。

Dioxins in fly ash from grate fired MSW incinerators were formed from precursors and those from fluidized bed incinerators were formed from de novo synthesis .

端粒酶（telomerase）是核糖核酸和蛋白质的复合体，是一种专一的逆转录酶，主要功能是以自身RNA为模板，从头合成端粒，维持染色体末端稳定。

Telomerase is a ribonucleic acid ( RNA ) - protein complex and a specialized type of reverse transcriptase , which synthesizes telomeric DNA onto chromosomal ends by using its RNA component as a template and contributes to chromosomal stability .

运用核苷酸补救途径理论，采用枯草杆菌肌苷产生菌，在培养过程中添加次黄嘌呤，作为从头合成途径（denovo）的补充。

Applying the theory of nucleotide salvage , we added the hypoxanthine to culture process of inosine producing mutants of Bacillus subtilis as supplement of de novo formation of inosine which made inosine synthesis improved greatly .

它们可以抑制动物体内脂肪酸的从头合成途径，乳脂中短链脂肪酸的比例减少，而CLA和TEA的比例相对升高，导致奶牛的乳脂率降低。

The de nove fatty acid synthesis was inhibited by CLA and TFA , which caused the content of short chain fatty acid in milk fat to decreased , whereas the proportions of CLA and TFA increased relatively subsequently the reduction of milk fat content .

外源生长素处理能够诱导Crl5的表达，并且这种诱导表达不需要蛋白的从头合成，而需要AUX/IAA的降解。

Exogenous auxin treatment induced CRL5 expression without denovo protein biosynthesis , which also required the degradation of AUX / IAA proteins .

PCDD/F从头合成的影响因素和抑制方法

Influence factors and control means of de novo synthesis of PCDD / F

水对二恶英从头合成影响的试验研究及二恶英从头合成的模型验证

Experimental and Modeling Study on the Role of Water in De Novo Synthesis of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans

而且在合子时期存在的父本转录本可能有两种来源：精子携入和从头合成。

And the paternal transcripts may come from both sperm delivery during fertilization and de novo transcription in zygote .

废弃物焚烧飞灰中从头合成二恶英的试验研究&氧、碳、催化剂的影响

Experimental study on pcdd / fs formation on waste incinerator fly ash via de novo SYNTHESIS-EFFECTS of oxygen , carbon and catalyst

这些小鼠脂肪组织内脂质从头合成的明显增加使得它们对于饮食脂质暴露的不利影响具有抵抗能力。

A robust increase in denovo lipogenesis rendered the adipose tissue of these mice resistant to the deleterious effects of dietary lipid exposure .

影响二恶英从头合成的因素有碳源、氯源、氧气、水、颗粒表面特性、温度、停留时间、催化剂和抑制剂等。

The influenced factors of denovo synthesis of dioxins may be carbon , chlorine , oxygen , water , nature of the ash 's surface , temperature , residence time , catalyzer and inhibitor , etc.

因为在绝大多数的动物体内，核苷酸的合成原料并不依赖消化道的吸收来提供，而是以氨基酸及其代谢产物为主要原料的从头合成和补救合成途径来满足机体的需要。

In most animals , the materials needed by nucleotide synthesis are not absorbed from digestive systems , but from amino acids and their metabolizing products through two pathways named as de novo synthesis pathway and salvage synthesis pathway .

采用高分辨气相色谱和低分辨质谱联用（HRGC/LRMS）的二恶英检测方法，研究了340℃时氧、碳、催化剂3个重要因素对飞灰中二恶英从头合成的影响。

High Resolution Chromatography / Low Resolution Mass Spectrometer technology is used for investigating the effects of oxygen , residue carbon and catalyst on PCDD / Fs formation via de novo synthesis in MSW fly ash at 340 ℃ .

选用煤和垃圾混烧的焚烧炉飞灰，研究了飞灰粒径分布对有机／无机氯源从头合成中二恶英生成的影响，以及不同无机氯源在从头合成中的相对作用。

The effects of particle distribution of fly ash from a MSW incinerator on de novo formation of dioxins with the use of organic / inorganic chorine sources and the relative action of different chlorine sources in de novo formation are studied .

研究表明，从头合成反应和前驱物异相催化反应是形成二恶英的最主要反应，其影响因素包括温度、反应的烟气环境、氧量、氯源、催化剂等；

Studies show that the de novo synthetic reaction and the outphase catalytic reaction of the precursors are the must major ones for formation of dioxin . The influence factors include temperature , flue gas atmosphere of said reactions , oxygen content , chloride source , and catalysts etc.