丙戊酸钠

丙戊酸钠分别与化疗药5-FU、DDP、ADM联合有体外协同抗肿瘤作用。

VPA in combination with chemotherapeutics 5-FU , DDP or ADM had synergistic antitumor effects .

结论TPM在低剂量时对大鼠胚胎骨骼发育影响较小，而高剂量及与丙戊酸钠联合用药时影响较大。

Conclusions : The influence of TPM on the embryonic skeleton development of rats was small when administered in low dosage , but became obvious when administered in high dosage or in combination with VPA .

丙戊酸钠抑制肺癌细胞株A549增殖的研究

Proliferation inhibition of sodium valproate on lung cancer cell line A549

丙戊酸钠对Kasumi-1细胞VEGF、bFGF表达的影响

Effect of valproic acid on the expression of VEGF and bFGF in Kasumi-1 cell

丙戊酸钠慢性作用及停药后对C6神经胶质瘤细胞释放谷氨酸和谷氨酰胺的影响

Effects of chronic valproic acid sodium treatment and withdrawal on glutamate and glutamine release of C6 glioma cells

丙戊酸钠合并氟哌啶醇治疗难治性Tourette综合征

A compared study of treating refractory Tourette ′ s syndrome with valproic acid combining haloperidol

丙戊酸钠诱导Siha细胞周期阻滞的实验观察

Cell cycle block induced by sodium valproate in Siha cells

目的研究丙戊酸钠（VPA）对托吡酯（TPM）神经保护作用的影响。

Objective To study the influence of valproate sodium ( VPA ) on neuroprotective effects of topiramate ( TPM ) .

给予丙戊酸钠（VPA）治疗发现可增高海马和皮层NPY浓度。

After administration of valproic acid ( VPA ) elevated levels of NPY were found both in hippocampus and in cortex .

与模型对照组相比，抗痫低剂量组、抗痫高剂量组，丙戊酸钠组海马NMDA受体活力降低，但差别无显著意义；

The three treatment groups had no significant difference in hippocampus compared with the model group , although their activity of NMDA receptor was decreased .

目的：研究氯硝西泮（clonazepam，CZP）对丙戊酸钠（Sodiumvalproate，VPA）的药代动力学及药效学的影响。

OBJECTIVE : To study the effect of clonazepam ( CZP ) on the pharmacokinetics and pharmacodynamic of sodium valproate ( VPA ) .

目的探讨丙戊酸钠（VPA）与卡马西平（CBZ）对脑电活动的影响。

Objective To explore the effect of VPA and CBZ ( valproate and carbamazepine ) on the electroencephaletro activity .

目的：探讨丙戊酸钠（VPA）和卡马西平（CBZ）对脑电图的影响。

Objectives : To investigate the effect of valproic acid ( VPA ) and carbamazepine ( CBZ ) upon electroencephalogram .

当苯巴比妥钠（PBS），丙戊酸钠（SV）的TDM（？）值分别大于18.21mg/ml、74.25mg/ml时，AKP活性增加。

When concentration of phenobarbital sodium and sodium valproate in blood were more than 18.21mg/ml and 74.25mg/ml respectively , AKP activity increased .

因此，本课题作了如下研究：一、建立孤独症动物模型：在Wistar大鼠孕期第12.5天时，给予一次性腹腔注射丙戊酸钠（VPA），获得子代鼠孤独症动物模型。

The autism animal model was obtained in offspring of the Wistar rats that received a single does of valproate ( VPA ) intraperitoneal injection at the pregnancy day of 12.5 .

方法对126例癫痫患儿使用丙戊酸钠达稳态血药浓度后，采用荧光偏振免疫法（FPIA）测定其血药浓度，并分析结果。

Methods The drug serum concentration in126 epileptic cases was determined fluorescence polarization immunoassay ( FPIA ) . The results had been analyzed .

丙戊酸钠对Kasumi-1细胞株血管新生相关因子表达的影响及意义的研究

The Study of Influence and Significance of Angiogenesis Relative Factors on Kasumi-1 Cell Line Treated with Valproic Acid

目的：研究并比较丙戊酸钠（VPA）对成、幼年大鼠血脂、血清瘦素及大脑皮质的影响。

OBJECTIVE : To study the effects of valproate acid ( VPA ) on serum lipid and leptin levels and cerebral cortex in juvenile and adult rats .

目的研究妥泰（TPM）高、低剂量单药及与丙戊酸钠（VPA）合用对大鼠胚胎骨骼发育的影响。

Objective : To study the embryonic skeleton developmental effect of topiramate ( TPM ) in rats in low dosage or high dosage or in combination with valproate acid ( VPA ) .

为进一步研究丙戊酸钠（Sodiumvalproate；VPA）对白血病细胞HL-60的增殖、凋亡和分化的影响，采用MTT法检测不同浓度的VPA对HL-60细胞增殖的作用；

To investigate the influence of sodium valproate ( VPA ) on proliferation , apoptosis and differentiation of HL-60 cell line , effect of VPA in various concentrations on proliferation of HL-60 cells was detected by MMT ;

对皮质醇、促肾上腺皮质激素、丙戊酸钠、维生素B6、γ-氨基丁酸类药物及一些新药非氨酯有些效果；γ－氨基丁酸（GABA）；

Certain response to treatment with adrenocorticotropic hormone ( ACTH ), corticosteroids , VPA , pyridoxine , γ - aminobutyric acid ( GABA ) ergic drugs ( benzodjazepines ,γ - vinyl-GABA ) and some new AEDs such as FBM ;

对5例接受丙戊酸钠缓释片（20～25mg·kg~（-1）·d~（-1），qn，po）治疗的初诊癫痫儿童（5～11a）进行药物动力学研究。

We studied the pharmacokinetics of sustained-release sodium valproate in five children ( 5-lla ) which were first diagnosed with epilepsy and treated in 20-25mg / ( kg · d ), qn , po .

p-CREB在抑郁症发病中的作用及丙戊酸钠的抗抑郁机制神经肽在动物抑郁症发生发展中的作用研究

The Role of p-CREB in Development of the Depression and the Mechanism of the Anti-depression Effect of Valproate ; The Involvement of Neuropeptides in Depression Genesis and Development

方法：对自由进食及限定进食的ICR小鼠分别以渗透压微泵技术（1.062mg·h~（-1））及iv（50mg·kg~（-1））给予丙戊酸钠，并测定VA动力学的时间依赖性变化。

METHODS : Sodium valproate was administered by osmotic minipump technique ( 1 . 062 mg · h-1 ) and iv ( 50 mg · kg-1 ) to ICR mice fed under ad lib or time-restricted schedules to determine the time-dependent changes of VA kinetics .

目的建立中国癫痫儿童丙戊酸钠（VPA）的群体药动学（PPK）模型，促进个体化用药。

OBJECTIVE To set up a population pharmacokinetic ( PPK ) model of Valproate ( VPA ) in children with epilepsy in China , and promote reasonable use of antiepileptic drugs ( AEDs ) in clinical practice .

目的应用临床流行病学方法评价丙戊酸钠（VPA）与卡马西平（CBZ）治疗小儿全身性强直-阵挛性发作（GTC）及部分性/继发全身性发作（P±GTC）的疗效和副作用。

Objective To evaluate the efficacy and side effects of valproate sodium ( VPA ) compared with carbamazepine ( CBZ ) monotherapy in children with generalized tonic-clonic epilepsy ( GTC ) and partial epilepsy with / withot secondary generalized epilepsy ( P ± GTC ) .

结果：托吡酯组治疗6mo的继发性全身发作，简单及复杂性部分发作有效例数优于丙戊酸钠组，4例在加药期快时出现疲劳、嗜睡、注意力不集中等。

RESULTS : Simple and complex partial seizures with or without secondary generalized seizure , in topiramate group were much more improved than these in sodium valproate group 6 mo after treatment .

方法将符合CCMD-3躁狂发作或分裂情感障碍诊断标准的68例研究对象随机分成两组，研究组应用奎硫平合并碳酸锂或丙戊酸钠，对照组单一使用碳酸锂或丙戊酸钠，治疗观察6周。

Methods : The 68 patients meeting criteria of manic episode or schizoaffective disorder in CCMD-3 were randomly divided into studying group ( combination of quetiapine and lithium or valproate ) and control group ( single using of lithium or valproate ) and observed for 6 weeks .

丙戊酸钠治疗迟发性运动障碍的双盲对照研究

A double-blind comparative study of sodium valproate in treating of TD

癫痫患儿使用丙戊酸钠缓释片时的血药浓度监测

The Blood Drug Concentration Monitoring of Sustained-Release Valproate in Epileptic Children