鼻黏膜

鼻腔应用类固醇激素对鼻黏膜辐射性损伤组织形态学变化的影响

Effects of intranasal corticosteroids on radiated nasal mucosa of guinea pig

缩鼻黏膜药物在慢性鼻炎鼻窦炎性病变CT诊断中应用价值

Application of nasal mucosa angiotonica during the diagnosis of chronic rhinitis and sinusitis

B组由于持续变应原接触，鼻黏膜病变进一步加重；

In Group B , due to continuously contact with allergen , the mucosa remodeling enhanced .

慢性鼻窦炎鼻黏膜上皮TNFα和IL-1βmRNA的表达

Expression of TNF α and IL-1 β mRNA in the nasal epithelial cell of chronic sinusitis

而正常鼻黏膜NOS呈阴性。

The normal nasal mucosa was negative .

缺氧和IL-1β对人鼻黏膜上皮细胞环氧化酶-2表达和前列腺素E2释放的影响

Effect of hypoxia and IL-1 β on COX-2 expression and PGE2 release in human nasal epithelia

结论：穴位刺血疗法对实验性变应性鼻炎大鼠下丘脑垂体肾上腺轴紊乱和鼻黏膜异常的P物质水平有明显的调整作用。

Conclusion Point pricking blood therapy has regulative effect on abnormal levels of substance P in the hypothalamus pituitary adrenal axis and the nasal mucosa in the rat of experimental allergic rhinitis .

变应性鼻炎大鼠鼻黏膜中补体调节蛋白C1-INH和CD46的表达

Expression of complement regulatory proteins C_1-INH and CD46 in nasal mucosa of allergic rhinitis rats

光镜下观察各组鼻黏膜的病理形态变化。结果：1.模型组兔血清IL-8、TNF-α含量明显升高，与正常组相比有极显著性差异（P＜0.01）。

To observe the nasal mucosa under the microscope . Results : 1.The model group rabbits serum IL-8 , TNF-a compared with the normal group significant difference .

原癌基因C-jun在大鼠变应性鼻炎鼻黏膜炎症细胞的表达及相关性研究

Expression of oncogene C-jun in the cells of rat nasal mucosa and relevance with rhinorrhea

内毒素刺激前后鼻黏膜上皮细胞中Toll样受体4mRNA及核因子κBp50亚型mRNA的表达及意义

Expression and significance of Toll like receptor 4 mRNA and nuclear factor - κ _B p50 mRNA in human normal nasal mucosa after stimulation by lipopolysaccharide

内毒素对离体鼻黏膜上皮细胞IFN-γ、IL-4表达的影响

The Effect of Endotoxin to Expression of IFN - γ and IL-4 in Human Nasal Epithelial Cell in vitro

结论BTA可诱导豚鼠鼻黏膜浆液腺细胞凋亡。

Conclusion BTA can induce apoptosis in nasal serous glands of guinea pig .

目的探讨重症肌无力（MG）的特异性体液免疫异常及双类似物（Lys262Ala207）鼻黏膜免疫耐受的疗效。

Objective To investigate the specific humoral immunity and the therapeutic effect of nasal tolerance with a dual analogue ( Lys262-Ala207 ) in the patients with myasthenia gravis ( MG ) .

目的观察不同浓度的川芎嗪、冰片在鼻腔灌流时，对鼻腔总蛋白（TP）和乳酸脱氢酶（LDH）释放，以及鼻黏膜形态的组织病理学影响。

OBJECTIVE To study the effects of the ligustrazine , synthetic borneol on the TP , LDH and mucosa morphous when perfusing nasal cavity .

目的：通过制备豚鼠变应性鼻炎动物模型，观察并分析内源性一氧化碳（CO）的限速酶血红素氧合酶1（HO1）在豚鼠鼻黏膜组织中的表达。

Objective : To study the expression of a specific inhibitor of endogenous carbon monoxide ( CO ) generating enzyme Heme oxygenase - 1 ( HO-1 ) in allergic rhinitis guinea pigs .

结论：BTA可降低豚鼠鼻黏膜腺细胞乙酰胆碱酯酶的浓度。

Conclusion : BTA can decrease the concentration of acetylcholinesterase in nasal glands of guinea pig .

IFN-γ鼻黏膜免疫耐受治疗EAMG的实验研究

Immune Tolerant Treatment of Nasal Mucosa with IFN - γ to EAMG

结果：B组用药第1、2、3周鼻黏膜的损害逐渐加重，3周后停药，第8周取材，观察损伤鼻黏膜形态没有恢复正常。

Result : The damages in Group B of nasal cavity mucosa of the 1st , 2nd , 3rd week was aggravated gradually , histomorphology and ultrastructure of nasal cavity mucosa had no recovered after withdrawing drug until 8th week .

中药复方能明显改善鼻黏膜病理反应；并通过多层次，多角度调节相关细胞因子mRNA的表达，对AR有很好的防治作用。

Chinese medicine can significantly improve the nasal mucosa pathological response ; and through multi-level , multi-angle on the regulation of cytokine mRNA expression , can play a very good preventive effect .

嗜酸粒细胞阳离子蛋白（ECP）对鼻黏膜上皮具有破坏作用，其含量代表Eos的活性。

Eosinophil cationic protein ( ECP ) can injury the nasal epithelium , the contain of ECP may show the activity of Eos .

目的：本研究旨在探讨射频热凝双侧翼管、筛前神经丛集区对变应性鼻炎（AR）血清及鼻黏膜中神经肽的影响。

Objective : The present study aims to discuss the influence of radiofrequency thermo-coagulation to vidian and anterior ethmoidal nerves on neuropeptides in serum and nasal mucosa of allergic rhinitis ( AR ) .

结果：变应性鼻炎大鼠鼻黏膜P物质含量明显高于同期正常对照组，下丘脑、垂体、肾上腺、血浆P物质水平则低于正常对照组（P<005）。

Results The levels of substance P in the nasal mucosa in the model rats were higher , and in the the hypothalamus , pituitary , adrenal gland and plasma were lower than those in the normal control group ( P < 0 05 ) .

方法以PLA为载体材料，采用复乳法制备NT-Ⅰ-PLA-NPs，并考察其体外药剂学性质、鼻黏膜给药的体内药动学特征及体内外相关性。

Methods NT - ⅰ - PLA-NPs were prepared by a double emulsion method . Their pharmaceutical characters in vitro 、 pharmacokinetics in vive through nasal administration were studied respectively .

bFGF-NP在血浆和鼻黏膜匀浆液中的稳定性较bFGF明显提高。

The stability of bFGF-NP in rat plasma and rabbit nasal mucosa tissue homogenate was increased obviously .

结果：SP激发能诱发正常的豚鼠出现相似的变应性鼻炎症状，并能加重模型组豚鼠变应性鼻炎症状和鼻黏膜炎症（P<0.01）。

Results : SP stimulated typical symptoms in normal group similar to those in AR group , and aggravated the symptoms and histopathologic inflammatory reactions in AR groups ( P < 0.01 ) .

结论：目前数据表明双侧翼管、筛前神经丛集区射频热凝治疗AR能减少血清及鼻黏膜中SP、VIP和NPY水平。

Conclusions : The present data indicated that radiofrequency thermo-coagulation to vidian and anterior ethmoidal nerves treat AR can reduce these SP , VIP and NPY levels in serum and nasal mucosa .

[目的]探索可生物降解乳酸/羟基乙酸共聚物[poly（lactic-co-GlycolicAcid），PLGA]纳米粒（nanoparticle，NP）作为大分子蛋白质药物的载体经鼻黏膜给药的可能性。

[ Objective ] To investigate the possibility of [ poly ( lactic-co-glycolic acid ) , PLGA ] nanoparticles ( NP ) as a new kind of protein drug carrier for nasal administration .

目的：探讨真菌诱导的豚鼠变应性鼻炎鼻黏膜中Eotaxin基因的表达及其意义。

Objective : To study the expression and significance of Eotaxin gene in nasal mucosa of guinea pig sensitized by fungal allergen .

结论变应性鼻炎鼻黏膜组织中补体C3、C4mRNA表达水平上调，提示补体系统参与变应性鼻炎的病理生理过程。

Conclusion The high level of C3 and C4 mRNA expression in nasal mucosa of rats with allergic rhinitis suggests that C3 and C4 are involved in the immunopathology of allergic rhinitis .