近曲小管

该组近曲小管上皮细胞肿胀，出现颗粒变性。

In the later killed group , proximal convoluted tubule epithelial cellular swelling !

研究结果提示：雌、雄大鼠近曲小管和集合管的功能可能存在显著的性别差异。

It is suggested that the function of the proximal convoluted tubule and the collecting duct may exist sexual differences .

两组相比，无统计学意义。病理学检查：B组大部分近曲小管上皮细胞严重浊肿，胞浆疏松，有空泡变性，部分近曲小管上皮细胞坏死。

On histopathology , in group B , the epithelial cells showed severe degeneration changes in proximal convoluted tubules .

结果CB在近曲小管表达最高，在肾小球和肾小管其他部位表达较少。

Results The cathepsin B expression was strong in renal proximal tubule .

iNOS仅分布于皮质远、近曲小管上皮。

INOS was in distal and proximal tubules epithelial of renal cortex ;

而在肾病综合症大鼠中，近曲小管（PT）对白蛋白的摄取速率被减弱。

In nephrotic rats , the rate of uptake of albumin by the proximal tubule ( PT ) is decreased .

传统的治疗药物如巯基络合剂EDTA，因其促进汞的排泄无特异性，易导致微量元素代谢紊乱，同时也会导致肾脏近曲小管上皮细胞受损伤，甚至产生肾毒性。

Many conventional medicines like EDTA can result in metabolic disorders of microelements , even renal toxicity .

肾组织24h后出现近曲小管上皮细胞崩解、坏死、尿液外渗；

The change of renal histopathological and necrosis at the epithelia of renal tubule appear after 24h .

结论：（1）肾组织CB、CC主要在肾近曲小管上皮细胞胞浆内表达，其它部位表达较少。

Conclusion : ( 1 ) The CB and CC was chiefly expressed in proximal tubular epithelial cells .

结果：（1）无纤维化组CB、CC在近曲小管上皮细胞表达最高，在肾小球、肾小管其它部位表达较少。

Results : ( 1 ) The CB and CC of no fibrosis group expressed strongest in renal proximal tubular epithelial cells .

组织学观察糖尿病组大鼠亦显示肾小球肥大，系膜区增宽及部分肾小球囊壁、近曲小管基底膜出现PAS阳性均质蛋白性物质。

Diabetes rats also showed glomerulus overgrowth , broadened mesentery and Pas positive albumoid materials in proximal convoluted tuble basement membrane and some glomerulus cyst wall .

目的：了解中毒性急性肾衰（ARF）早期肾近曲小管上皮细胞（PTC）细胞骨架微丝和微管的改变，并探讨其改变的机制。

Purpose To study the alterations and its mechanism of the microfilament and the microtubule of the proximal tubular cell ( PTC ) in toxic acute renal failure .

结果：近曲小管上皮细胞AT-1受体的分布和分泌IL-6的量均显著高于集合管上皮细胞；

The results showed that AT1 receptor expression and IL6 release in PCT epithelial cells were significantly more than those in those of CD .

本研究观察了顺铂（CDDP）对猪肾近曲小管上皮细胞（LLC－pK＿1）增殖与DNA合成代谢的影响以及亚硒酸钠与硒代蛋氨酸的保护作用。

LC-pK_1 the pig kidney cell line , was utilized in studying mechanisms of nephrotoxicity induced bycisdiamminedichloroplatium ( CDDP ) and the protective effect , of sodium selenite and selenomethionine .

1250mg／m3染毒组大鼠肾组织近曲小管上皮细胞浊肿，线粒体肿胀变性。

The kidney proximal convoluted tubule cells of rats in 1250mg / m 3 group were swelling and the mitochondria in them were degenerated .

H-73-10和DTPA对大鼠肾近曲小管上皮细胞超微结构的影响

Effects of h-73-10 and DTPA on the ultrastructure of epithelial cells in proximal convoluted tubules of kidney in rats

结论CB主要在肾近曲小管表达，其表达减少是细胞外基质（Extracellularmatrix，ECM）降解减少的原因之一，参与肾组织纤维化的发生机制。

Conclusion The cathepsin B was located in the proximal tubule . The decreased expression of cathepsin B resulted in the over deposition of extracellular matrix ( ECM ) in some degree , which might contribute to the forming of renal fibrosis .

目的研究乙酰唑胺抑制大鼠肾脏近曲小管上皮细胞水孔蛋白1（aquaporin1，AQP1）表达的内源性机制。

Aim To study the endogenous mechanism for the inhibition of aquaporin 1 expression in rat renal proximal tubule epithelial cells in response to acetazolamide .

HSP73从胞核弥散至胞浆中，并以颗粒的形式积聚于近曲小管上皮细胞中。

HSP73 translocated from the nucleus to the cytoplasm and accumulated in granules in the proximal tubular epithelial cells .

PAR-2表达主要定位于肾小管上皮细胞（尤其为近曲小管），也可见于肾毛细血管袢、间质浸润细胞和成纤维细胞。

PAR-2 mainly expressed in renal tubular epithelial cells , especially in proximal tubular cells . It also located in renal capillary ansa , interstitial infiltrate cells and fibroblast .

结果：190%的正常肾组织近曲小管上皮细胞膜和/胞质有P-gp表达；P-gp、GST-л和TOPO蛋白在肾细胞癌组织中的阳性表达率分别为77.8%，71.1%和31.1%。

Results : ① the positive expression of P-gp was 90 % in kidney tissue , and that of P-gp , GST - л and TOPO ⅱ separately were 77.8 % 71.1 % and 31.1 % in RCC .

目的探讨镉诱导猪肾近曲小管上皮细胞（LLC-PK1）凋亡对bcl-2、p53（mtp53）、c-Mycc、-fos与ras基因表达的影响。

Objective To explore the effect of cadmium on the apoptosis of porcine renal proximal tubule epithelial cells ( LLC-PK_1 ) and the relationship between the apoptosis and the bcl-2 , p53 , c-myc , c-fos and ras gene expression .

方法：免疫组化和RT-PCR方法观察PPAR-γ在Han：SPRD大鼠不同表现型肾组织、人近曲小管细胞系（HKC）、囊肿衬里上皮细胞（PKD）中表达分布。

Methods : PPAR - γ expression in different genotypes of Han : SPRD rat kidney tissues , cyst-lining epithelia , human kidney cortex cell line ( HKC ) are studied by RT-PCR and immunohistochemistry .

结果c-fos蛋白分布于近曲小管、远曲小管、集合管上皮细胞的细胞核、细胞浆内，再灌注后1h表达明显增强，3h达高峰，6h锐减。

Results Localization of fos protein expression occurred in nuclei and cytoplasm of the proximal convoluted tubules 、 distal convoluted tubules and collecting duct cells . Fos protein started to increase at 1h , peaked at 3h , and reduced rapidly at 6h .

MI代谢途径的第一步关键反应由肌醇加氧酶（myoinositoloxygenase，MIOX）这一加单氧酶催化，该反应主要发生于肾皮质的近曲小管上皮细胞。

The first committed step in MI metabolism pathway is catalyzed by the monooxygenase , myoinositol oxygenase ( MIOX ), which occurs predominantly in the proximal tubular epithelial cells of the kidney cortex .

目的：探讨细胞培养液中有、无小牛血清对镉诱导猪肾近曲小管上皮细胞（LLC-PK1）损伤的影响，为研究镉对LLC-PK1细胞毒性的方法提供依据。

Objective : To identify the effect of porcine renal proximal tubule epithelial cells LLC-PK_1 induced by cadmium in medium with or without serum .

目的研究体外培养的人肾脏近曲小管上皮细胞（PTEC）自身以及在肿瘤坏死因子α（TNF－α）诱导下补体第三成分（C3）的基因表达和蛋白合成。

Objective To examine the gene expression and protein biosynthesis of the third component of complement ( C3 ) in human proximal tubular epithelial cells ( PTEC ) stimulated by cytokine tumour necrosis factor - α ( TNF - α) .

应用细胞形态学（光镜和电镜）、免疫细胞化学（PanCK和CK18单抗）和酶组织化学（酸性磷酸酶和碱性磷酸酶）方法进行肾近曲小管上皮细胞鉴定；

Morphological analysis ( electron microscope , light microscope ), immunocytochemistry ( PanCK , CK-18 ) and enzyme histochemistry ( acid phosphatase , alkaline phosphatase ) were used in identification of proximal tubular epithelial cells .

目的：探讨复方积雪草有效组分&积雪草苷/大黄素干预肿瘤坏死因子-α（TNF-α）诱导的人肾近曲小管上皮细胞（HPTEC）补体C3mRNA及蛋白的表达水平。

Objective : To investigate the effects of effective component from Centella asiatica component ( centella asiatica & emodin ) on complement C3 mRNA and protein in human proximal tubular epithelial cells ( HPTEC ) stimulated by tumor necrosis factor - α( TNF - α) .

人肾脏近曲小管上皮细胞表达α1抗胰蛋白酶的研究

Expression of alpha 1 anti-trypsin in proximal tubular epithelial cell line