负调控

PI3KγmRNA3′非翻译区可能存在基因表达负调控区

Probable Existence of a Negative Regulation Region Within the 3 ′ UTR of Human Phosphoinositide 3-Kinase γ mRNA

近年来，TLRs信号转导的研究，特别是在负调控研究领域，进展非常迅速。

In recent years , studies on the TLRs signaling , especially their negative regulation , rapidly progressed .

最近，细胞质RNA介导的抗病毒信号的负调控因子的识别，引起了足够的重视。

Recently , identification of negative regulators for cytoplasmic RNA-mediated antiviral signaling attracts much attention .

细胞间接触和可溶性分子均参与MSC对DC发育的负调控，且细胞间接触发挥更大作用。

Cell-cell contact and soluble factors were involved in this inhibition with cellular contact played a more important role .

由此我们证明Aurora-A的N端对于激酶活性确有负调控作用。

So we presume the N-terminal of Aurora-A can negatively regulate the Aurora-A kinase activity .

p53负调控前列腺癌细胞中PC-1基因的表达

P53 Negatively Regulates PC-1 Expression in Prostate Cancer Cells

Myostatin基因即肌肉生长抑制素，是一种肌肉生长的负调控因子。

Myostatin is a negative regulator of skeletal muscle growth .

锌吸收调控蛋白（Zincuptakeregulator，Zur）是一个金属调控蛋白，在许多细菌中负调控高亲和性的锌吸收系统。

Zur ( Zinc uptake regulator ) is a metalloregulatory protein , which negatively regulates the high-affinity zinc uptake systems in many bacteria .

抑癌基因Pten编码磷酸酶，负调控磷脂酸肌醇3-激酶（PI3K）途径的活性。

The Pten tumor suppressor gene encodes a phosphatase that negatively regulates the phosphatidylinositol 3-kinase ( PI3K ) pathway activity .

进一步研究发现，GKO小鼠中CD4和CD25双阳性调节性T细胞，在外周免疫器官的发育并没有受到影响。因此，γ-干扰素可以负调控DC的迁移及T细胞免疫应答。

Moreover , IFN - γ was not required for the development of CD4 + CD25 + regulatory T cells .

PTEN是一种抑癌基因，通过负调控PI3K/AKT途径调节细胞增殖、存活、生长与迁移等。

PTEN is a anti-oncogen , which can mediate cell proliferation , survivorship , growth and migration by negatively regulate PI3K / AKT .

人IL-2Rα链基因负调控元件结合蛋白的分离纯化

Purification of the Negative Regulatory Element - Binding Protein of Human IL - 2 Ra Gene

结论：银耳多糖是通过调控细胞周期负调控因子p21的转录和表达、抗氧化及增强免疫功能而抗衰老的。

Conclusion : TP have anti-aging effects by regulating transcription and expression of cell cycle negative regulator p21 , anti-oxidation and strengthen immunity .

多数学者认为，PTEN蛋白可能通过多种途径负调控ERK/MAPK信号通路的激活。

Most of scholars considered that PTEN protein could inversely regulate and control the activation of ERK / MAPK signal pathway in many ways .

MicroRNAs（miRNAs）是一组小的单链非编码RNA分子，是重要的基因负调控因子。

MicroRNAs ( miRNAs ) are a set of small single stranded non-coding RNA molecules that serve as important negative gene regulators .

肌肉生长抑制激素（myostatin，MSTN）是骨骼肌的负调控因子，是影响肌肉生长与发育的重要因素。

As a negative regulator of skeletal muscle , Myostatin could influence the development and growth of muscle .

该结果表明Ⅳ型菌毛负调控APP生物被膜的形成，我们推测Ⅳ型菌毛可能参与了群体感应调节因子LuxS对于生物被膜形成的负调控过程。

We speculated that type ⅳ pili of APP could involve in the negative regulation of biofilm formation by LuxS , a quorum sensing regulator .

野生型p53基因属抑癌基因，其编码蛋白参与细胞生长的负调控，其主要生物学功能为引起细胞周期阻滞，促进细胞分化和诱导细胞凋亡。

The p53 gene ( wtp53 ) is a tumor suppressor gene , the protein encoded can negatively regulate the cell growth , whose main biological functions are to block cell cycle , promote cell differentiation and induce cell apoptosis .

结论：补肾泻肝方通过降低再障患者体内IFN-γ、IL-2水平，以解除负调控因子对造血抑制，促进骨髓造血功能恢复的作用。

We draw a conclusion that the prescription release the suppression of negative regulated factor to hematopoiesis and promote the function of hematopoiesis of bone marrow by reducing the level of IFN - γ, IL-2 of CAA .

以往研究证实，GSK-3β是一种内源性心肌肥大负调控因子。

According to the previous reports , GSK-3 β was a negative regulatory factor ( NRF ) for endogenous cardiomyocyte hypertrophy .

结论：Syt在RBL中表达，其对RBL溶酶体胞吐起负调控作用。

Conclusion : Syt2 expressed in RBL and it played a negative regulation during exocytosis of lysosomes in RBL .

背景：调节性T（RegulatoryT，Treg）细胞是一群具有抑制其他免疫细胞功能的负调控细胞，可通过多种方式抑制抗肿瘤免疫反应。

Background : Regulatory T ( Treg ) cells have the negative regulatory effect that can inhibit the function of other immune cells . It can inhibit the anti-tumor immune response by a variety of ways .

鼠p53172位点不同结构的minigene四环素负调控表达模式对肺癌细胞体外生长的影响

Effect of mouse p53 minigene on lung cancer cells with different 172 structures regulated by tetracycline

P53蛋白分为野生型和突变型，其突变型不但失去了对细胞增殖和分化的负调控作用，而且还能正向激活某些促生长基因的表达，从而促进细胞增殖导致肿瘤发生。

P53 protein into wild type and mutant , the mutation has not only lost their proliferation and differentiation of negative regulation , but also activate some positive growth-promoting gene expression , thus promoting cell proliferation , and leading to tumors .

结论：LWB-6预防给药对CIA关节炎有明显的干预作用，此作用与负调控DCT-bet表达相关。

CONCLUSION LWB-6 shows obviously preventive effects on CIA model , and which is associated with the negative control of DC T-bet transcription .

另外，本研究检测到花青素代谢相关基因在ECMs中呈现下调表达趋势，这一特征暗示类胡萝卜素积累负调控花青素合成。

In addition , some anthocyanin genes were down-regulated in the ECMs , which suggested that carotenoid accumulation could negatively regulated anthocyanin biosynthesis .

【目的】探讨JAK/STAT信号转导途径负调控子SHP-1基因启动子区域CpG岛异常甲基化在B细胞淋巴瘤中的意义。

[ Objective ] To investigate the methylation state of CpG island in the SHP-1 gene promoter which is one of the negative regulators of JAK / STAT signaling pathway and to evaluate its significance in B-cell lymphoma .

myostatin，也称为生长分化因子-8（growthanddifferentiationfactors-8，GDF-8，MSTN），可抑制骨骼肌生长，是肌肉生长负调控因子。

Myostatin , also known as growth differentiation factor-8 ( growth and differentiation factors-8 , GDF-8 , MSTN ) can inhibit the growth of skeletal muscle , which is a negative regulator of muscle growth .

缺失突变分析将PC1基因启动子上受p53负调控的区域定位在翻译起始位点上游757bp～323bp之间。

Deletion and mutation analyses mapped the region of the PC-1 promoter which was negatively regulated by p53 between the 757 bp ~ 323 bp which was upstream of the translation initiation site .

结果大肠癌的发生与mdm2高表达、p53低表达有关，mdm2与大肠癌局部发展、浸润、转移有明显相关性，p53起负调控作用。

Results The occurrence of colorectal cancer is related to high expression of mdm2 and low expression of p53 ; mdm2 is correlated with local development , infiltration and metastasis of colorectal cancer , while p53 plays a negative regulating role .