成神经细胞瘤

氟丙胺磷对人成神经细胞瘤SK-N-SH细胞分化的毒性机制

Neurotoxic mechanism of mipafox in differentiation of human neuroblastoma SK-N-SH cells

目的研究诱发迟发性神经病的氟丙胺磷对人成神经细胞瘤SK-N-SH细胞分化的影响及其作用机理。

AIM To investigate the effect of mipafox that induced delayed neuropathy on neural differentiation in human neuroblastoma SK-N-SH cells and elucidate its mechanism .

增强MRI对小儿成神经细胞瘤分期的应用价值

Enhancement MRI evaluation of neuroblastoma staging in children

目的探讨增强MRI对成神经细胞瘤分期的应用价值和限度。

Objective To evaluate the value and limitation of Gd-DTPA enhanced MRI for neuroblastoma staging in children .

方法分析12例经手术或骨髓针吸检查证实的成神经细胞瘤的增强MRI表现。

Methods Twelve cases of neuroblastoma proved by operation or bone marrow aspiration were examined by gadolinium-enhanced MRI .

据文献报道，NSE含量测定可作为肺癌、成神经细胞瘤、黑素瘤、精原细胞瘤以及中枢精神系统损伤的诊断指标。

NSE are reported to be useful diagnostic marker for lung cancer , neuroblastoma , melanoma , seminoma and in injury of central nervous system .

方法：采用人类APP695cDNA转染人成神经细胞瘤细胞株（HY-SY5Y）为模型，应用IP-Western印迹法检测不同浓度GM1处理后，细胞内Aβ生成量的变化；

METHODS : Human neuroblastoma cells transfected with human amyloid precursor protein ( APP ) cDNA were used to analyze the effect of the various concentrations of GM1 on the level of intracellular total A β by IP-Western blot .

术前化疗治疗成神经细胞瘤临床疗效和生物特性观察

Clinical and biological characteristics of preoperative chemotherapy in neuroblastoma

蛋白磷酸酶抑制剂对人成神经细胞瘤细胞钙瞬态的影响

The Heart Man Effects of Protein Phosphatase Inhibitor on Calcium Transient in Neuroblastoma Cells

蝙蝠葛碱拮抗缓激肽诱导人成神经细胞瘤细胞胞内钙升高的作用

Effect of Dauricine on Bradykinin - induced Increase of Cytosolic Free Calcium in Neuroblastoma Cell

结论根据患者年龄及特征性的X线表现，对成神经细胞瘤骨转移可作出诊断。

Conclusion Based on the pathogenetic age and characteristic radiologic findings , neuroblastoma metastasis to bone may be definitely diagnosed .

恶性肿物8例，其中横纹肌肉瘤5例，转移性成神经细胞瘤2例，泪腺腺样囊性癌1例。

Of 8 malignant lesions , 5 were rhabdomyosarcoma , 2 metastatic neuroblastoma and one adenoid cystic carcinoma of lacrimal gland .

该药物也被证明能加强现用的治疗成神经细胞瘤的细胞抑制剂的作用。

The substance also proved able to reinforce the effect of different cytostatics currently in use in the treatment of neuroblastoma .

背景和目的：成神经细胞瘤是儿科常见的恶性肿瘤之一，目前对于这种疾病的治疗，整体疗效较差。

Background Neuroblastoma is one of the most common pediatric solid tumor in children . At present , the overall outcome remains poor .

成神经细胞瘤的临床特点是治疗的基础，而治疗方法又由于确诊年龄、发病程度以及肿瘤生物学而各不相同。

The clinical hallmark of neuroblastoma is the prospect for cure varying widely depending on age at diagnosis , extent of disease , and tumor biology .

在其他癌症也出现初次检查显示增殖细胞核抗原的形态改变，其中包括食管癌，结肠癌，成神经细胞瘤及卵巢癌等。

Initial tests have revealed the altered form of PCNA in other cancers , including esophageal , colon , neuroblastoma , and ovarian cancers , Malkas said .

此外在一些肿瘤中端粒酶水平与患者的预后相关，如成神经细胞瘤、白血病、前列腺癌、胃癌和乳腺癌。

In addition , data from cancer patients indicate that telomerase levels correlate with clinical outcome in neuroblastomas , leukemias , and prostate , gastric , and breast cancers .

结论氟丙胺磷对人成神经细胞瘤细胞分化的抑制是通过对总的和磷酸化的神经纤维丝重链蛋白表达的抑制实现的，并伴随着神经病靶标酯酶的抑制。

CONCLUSION Mipafox inhibited the neural differentiation in human neuroblastoma SK-N-SH cell via the decrease in total NF-H and NF-H phosphorylation levels , which was associated with the inhibition of NTE activity .

结果13例成神经细胞瘤中12例表现为不规则肿块，11例边界不清，10例包含钙化，9例腹膜后血管受侵犯，12例有腹膜后和膈脚后淋巴结转移；

Results In 13 cases of neuroblastoma , CT showed irregular mass in 12 cases , tumor with poorly defined margins in 11 cases , tumorous calcifications in 10 cases , invasion of retroperitoneal vessels in 9 cases , and retroperitoneal and retrocrural lymph nodes invasion in 12 cases .

研究者总结说：小脑幕上原始神经外胚瘤与成神经管细胞瘤的患者接受放疗和大剂量化疗后，脑白质损伤通常短期存在，并不产生症状。

The investigators concluded that in patients with medulloblastomas or PNET who had been treated with irradiation and high-dose radiation , WMLs are typically short-lived and do not cause symptoms .

成神经管细胞瘤是一种小脑神经外胚层肿瘤，是最常见的儿童中枢神经系统肿瘤，发病率约占儿童脑肿瘤的25%，死亡率排在肿瘤疾病之首。

Medulloblastoma , the most common brain tumor in children , is a kind of primitive neuroectodermal tumor ( PNETs ) of cerebellum and account for approximately 25 % of all the tumors in CNS of childhood . It is a major cause of brain cancer mortality .