血液肿瘤

本文主要回顾CAR技术的革新、在血液肿瘤研究中应用现状和前景。

In this paper , we reviewed the technology innovation , application status and prospects of CAR technology in hematological malignancies .

目的研究血液肿瘤病人化疗后应用重组粒细胞集落刺激因子（rhG-CSF）对中性粒细胞功能的影响。

Objective To study the effect of recombinant human granulocyte colony-stimulating factor ( rhG-CSF ) on neutrophil function in patients with hematological malignancies receiving chemotherapy .

CIK与DC细胞免疫治疗在血液肿瘤中的临床应用

Clinical Application of CIK and DC in Cell Immunotherapy of Hematologic Tumor

结论提示部分恶性血液肿瘤患儿用PCR检测骨髓微量残留病可预测临床预后。

Conclusion Minimal residual disease detection in bone marrow by PCR might predict prognosis in some childhood hematological malignancies .

不同血液肿瘤细胞株survivin基因和蛋白表达及意义的研究

Expression of survivin gene and protein in hematological tumor cell lines

通过对Ara-C在不同剂量和疗程时抗白血病的机理研究，验证大剂量阿糖胞苷（HD-Arac）治疗血液肿瘤的优越性。

In addition to study the antileukemic mechanism of Ara-C.

血液肿瘤患者血清TNF、TGF-α的水平及临床意义

Alterations in the serum levels of TNF and TGF - α in patients with hematological malignancy and their clinical significance

目的探讨Survivin基因在血液肿瘤细胞株细胞的表达及其可能的机制。

Objective To investigate the expression profile of Survivin gene in hematological tumour cell lines .

第一部分，检测survivin基因在血液肿瘤细胞株细胞中的表达；

In the first section , survivin expression was first detected in hematological tumour cell strains .

方法应用PCR法检测38例血液肿瘤性疾病患儿骨髓细胞EBV-DNA。

Methods EBV infection in hematological malignancies 38 cases was detected by PCR .

检测103例血液肿瘤患者血清β&微球蛋白（简称Sβ2M）。

Serum β 2 microglobulin ( S β 2M ) was detected in 103 patients with haematological malignancies .

rhG-CSF对血液肿瘤病人化疗后中性粒细胞功能的影响

The Effect of rhG-CSF on Neutrophil Function in Patients with Hematological Malignancies During Chemotherapy

血液肿瘤患儿医院感染病原菌调查与分析新生儿溶血病患儿Rh血型的检测分析

Pathogens of Nosocomial Infection in Pediatric Patients with Hematologic Malignancy Identification and analysis on the Rh blood group of newborns with hemolytic disease

AnnexinⅡ在多发性骨髓瘤及其他血液肿瘤中的表达及机制研究

Studies on the Expression and Function of Annexin ⅱ in Multiple Myeloma and Other Neoplastic Hematologic Disorders

目的：了解氧化酚砷（Phenylarsineoxide，PAO）对血液肿瘤细胞系的影响。

Objective : To investigate effects of phenylarsine oxide ( PAO ) on hematopoietic maligant cell lines .

结论：检测血液肿瘤性疾病患者血清TNF、IL-6和TGF-α水平，有助于了解这类病人化疗后的病情变化及其预后。

Conclusion Serum TNF , IL-6 and TGF - α levels in patients with hematologic malignancies were closely related to the disease status and were of prognostic value .

采用WESTERNBLOTTING分析了6个血液肿瘤细胞株和4个临床样本中BSAP表达水平。

BSAP expression by Western Blotting analysis was performed in haematological tumor cells , including 6 haematological tumor cell lines and 4 clinical samples .

结论：survivin基因在血液肿瘤细胞株中普遍表达，survivin高表达可能与肿瘤细胞增殖及耐药有关。

Conclusion : Survivin gene expresses in haematological tumor cell lines at large , its high expression may relate with tumor cell proliferation and drug resistance .

重组腺病毒介导Survivin和GM-CSF基因修饰树突状细胞体外诱导抗血液肿瘤免疫的实验研究

In Vitro Induction of Anti-tumor CTL Effect Against Hematologic Malignancies by Dendritic Cells Infected with Recombinant Adenovirus Vectors Containing Human Survivin and GM-CSF Genes

第二部分：血液肿瘤患者真菌感染的DNA检测目的：1.用实时荧光PCR方法检测血液科发热病人血清中的曲霉菌DNA含量，并与GM试验和临床表现相对比，探索其一致性和准确性。

Objective : · Using Real-Time PCR to detect the content of Aspergillus DNA in serum of patients with fever , compare the result to GM test and clinical manifestations , explore the consistency and accuracy .

SDF-1与VEGF在不同类型恶性血液肿瘤中的表达及其意义

Expression and significance of stromal cell derived factor-1 ( SDF-1 ) and vascular endothelial growth factor ( VEGF ) in different hematologic malignant tumor

背景与目的：探讨高电压脉冲电场诱导K562细胞凋亡的情况，寻求血液肿瘤治疗的新途径。

BACKGROUND AND AIM : A new approach to kill tumor cells in the blood through investigating apoptosis of K562 cells induced by high intensity pulsed electric fields .

而缓解期与对照组比较差异无显著性（P>005），当上述血液肿瘤复发时，血清LDH水平又明显增高。

The CR group had no significant difference than the control group ( P > 0.05 ), when these hematologic malignancy relapsed , the serum LDH level increased obviously again .

目的：检测多聚阳离子复合物（Polycation）对腺病毒载体转染血液肿瘤细胞效率的影响。

Objective : To observe the influence of Polycation on the transfection efficacy of recombinant adenovirus .

目的检测SDF-1、VEGF在不同恶性血液肿瘤的表达水平，分析其在恶性血液肿瘤中的表达特点及其意义。

Objective To detect the expression level of SDF-1 and VEGF in the patients with hematologic malignant tumor , and to analyse the characteristic of the expression and its significance .

结论细胞内GSH水平和过氧化氢酶的活性是决定血液肿瘤细胞对As2O3敏感性的重要因素。

Conclusion Intracellular GSH level and / or catalase activity are important factors to determine sensitivity of malignant hematopoietic cells to As 2O 3 induced apoptosis .

采用PHMAO2单克隆抗体及细胞免疫化学法检测54例血液肿瘤患者P－糖蛋白（P－glycoprotein，Pgp）表达情况，以了解Pgp这一多药耐药指标在临床上的意义。

Expression of P-glycoprotein ( Pgp ) was determined using PHMAO_2 monoclonal antibody by immuno-cytochemical APAAP assay in 54 cases of hematological malignancies . The clinical significance of Pgp , a multidrug resistance index , was explored .

目的：研究survivin在不同血液肿瘤细胞株（Jurkat，Raji，EL-4，K562，K562/AO2）的表达，并探讨其与相关因素的关系。

Objective : To explore the expression of survivin in different haematological tumor cell lines ( Jurkat , Raji , EL-4 , K562 , K562 / AO2 ) .

目前已用于临床血液肿瘤治疗的三氧化二砷是一种传统的抗肿瘤中药，而在实体瘤的治疗方面，它可能通过去甲基化作用使ER阴性乳腺癌ER基因重新表达。

Arsenic trioxide which has been used to cure neoplastic hematologic disorder is a kind of traditional Chinese medicine with anti-tumor . In the treatment of solid tumors , it is speculated that gene ER may re-express by demethylation arsenic trioxide .

目的探讨血液肿瘤细胞对三氧化二砷（As2O3）的敏感性和细胞抗氧化能力的关系。

Objective To detect the relationship between sensitivity of malignant hematopoietic cells to arsenic trioxide ( As 2O 3 ) and cellular capacity against oxidation .