葡糖醛酸

玻璃酸（HyaluronicAcid，HA）是广泛存在于动物细胞间质中的一种高分子线性糖胺聚糖，由N-乙酰氨基葡糖和葡糖醛酸为双糖单位重复交替连接而成。

Hyaluronic acid ( HA ) is a linear glycosaminoglycan composed of alternating disaccharide unit containing N-acetylglucosamine and glucuronic acid , found in extracellular matrix of most animals .

结论transT代谢，M1生成及其与葡糖醛酸结合均具立体选择性和性别差异；

Conclusion In vitro , trans T metabolism , M1 formation and M1 glucuronidation were found to be stereoselective in rat liver microsomes .

结果在大鼠尿样中检测到7种I相代谢产物（如原药的脱氢、脱甲基、羟基化代谢物）及11种II相代谢产物（如甲基化轭合物和葡糖醛酸轭合物）。

Results At least seven phase I metabolites ( such as de-methyl , de-hydrogen and hydroxyl metabolites ) and eleven phase II metabolites ( such as glucuronide conjugates and methyl-conjugates ) were identified in rat urine .

在雌性大鼠肝微粒体中（-）M1优先与葡糖醛酸结合；

( + ) - M1 and ( - ) - M1 were preferentially glucuronidated in the liver microsomes of male and female rats , respectively .

分别用绿色荧光蛋白（GFP）基因、β葡糖醛酸酶（GUS）基因以及小鼠二氢叶酸还原酶（DHFR）基因3种报告基因置换CP基因。

The CP gene was replaced by green fluorescent protein ( GFP ) gene ,β glucuronidase ( GUS ) gene or mouse dihydrofolate reductase ( DHFR ) gene , respectively .

这些反应分别由UDP-葡糖醛酸转移酶（UDP-glucuronosyltransferases，UGT）和硫酸基转移酶所催化介导。

These reactions are catalyzed by UDP-glucuronosyltransferases ( UGT ) and sulfotransferases , respectively .

目的为建立能稳定表达人葡糖醛酸转移酶UDPGT1A9蛋白的CHLUDPGT1A9转基因细胞系，并鉴定其对药物的葡糖醛酸缀合活性。

AIM To establish a cell line CHL UDP glucuronosyltransferase gene ( UDPGT1A9 ) which will stably express human UDPGT1A9 protein and determine the activity of expressed UDPGT1A9 in drug glucuronidation .

β-葡糖醛酸酶在恒河猴组织中的分布

Distribution of β - Glucuronidase Activity in macaca mulatta Tissues

2种重组人源化葡糖醛酸化转移酶对染料木素代谢的作用研究

Effects of Two Recombinant Human Glucuronyltransferases Enzymes on the Metabolism of Genistein

本文介绍了一种血清β-萄葡糖醛酸苷酶活性测定法。

A colorimetric method for determining the serum β - glucuronidase activity was reported .

水/有机溶剂体系中产紫青霉全细胞催化合成单葡糖醛酸基甘草次酸

Biosynthesis of glycyrrhetinic acid monoglucuronide by whole-cell of Penicillium purpurogenum in an aqueous / organic system