莽草酸

异亚丙基莽草酸（3，4-oxo-isopropylidene-shikimicacid，ISA）是从中药木兰科植物八角茴香中提取的有效成分莽草酸的衍生物。

3,4-oxo-isopropylidene - shikimic acid ( ISA ) is a kind of derivative of shikimic acid ( SA ) which was a component extracted from Illicium verum Hook . fil .

关于莽草酸途径，酪氨酸对苯丙氨酸形成的反馈促进，暗示茶叶叶绿体含有这两种氨酸的生成酶系，但~（14）C示踪试验证明它缺少该途径的部分酶。

As to shikimic acid pathway , ~ ( 14 ) C-labelling experiment indicated that the chloroplast was short of some enzymes ( or at least one enzyme ) involved in the pathway , but the results above revealed that latter steps in the pathway were located in it .

方法采用水提-醇沉法对莽草酸进行提取，采用HPLC法测定莽草酸的含量。

Methods Shikimic acid was extracted with H2O , and HPLC was employed to determine shikimic acid .

结论异亚丙基莽草酸对H2O2损伤血管内皮细胞具有保护作用。

Conclusion ISA exerted protective effect on H_2O_2 injured HUVEC .

自禽流感病毒和甲型H1N1流感病毒爆发后，莽草酸就备受关注。

It has been concerned by people ever since the influenza and H1N1-influenza broke out .

目的：建立3，4-O-异亚丙基莽草酸（ISA）在小鼠血浆及组织样品中的RP-HPLC分析方法；对ISA静注给药在小鼠体内分布的行为进行研究。

Objective : To establish an RP-HPLC method for the study of tissue distribution of3,4-o-isopropylidene-shikimic acid ( ISA ) in mouse in vivo .

EPSP合成酶是莽草酸途径的一个关键酶，其成熟蛋白在进化中极为保守。

The EPSP synthase is a necessary enzyme of the shikimate pathway and it is very conservative .

水杨酸（Salicylicacid，SA）是植物莽草酸代谢途径中的一种酚类衍生物，参与植物细胞信号传导，对植物的生长、开花、产热、离子吸收、抗逆性等生理过程具有调节作用。

Salicylic acid is a phenolic derivative of phenylpropanoid metabolism , involved in cell signal transduction in plant . It has direct involvement in plant growth , thermogenesis , flower induction , uptake of ions and stress resistance .

在选定波长（215、220、224、226、230nm）处测定不同pH值的莽草酸溶液吸光度值，得到莽草酸的离解常数为3.87±0.08。

Different absorption values of shikimic acid solutions at five chosen wavelengths ( 215 、 220 、 224 、 226 、 230 nm ) have been determined .

结果6个蛋白分别为海藻糖磷酸磷酸酶、铁钼蛋白A、莽草酸5脱氢酶、葡萄糖胺果糖6磷酸氨基转移酶、吲哚3甘油磷酸合成酶、TetR家族转录调控因子。

Results Six spots of proteins in gel were identified as trehalose-6-phosphate phosphatase , moaA , shikimate 5-dehydrogenase , glucosamine-fructose-6-phosphate aminotransferase , indole-3-glycerol phosphate synthase and TetR-family transcriptional regulator .

目的研究异亚丙基莽草酸（ISA）对大脑中动脉缺血再灌注大鼠的神经症状评分、脑梗死范围、脑组织含水量及髓过氧化物酶（MPO）活性的影响。

Objective To study the effects of 3,4_oxo_ isopropylidene shikimic acid ( ISA ) on nerve symptom scale , cerebral infarct size , hydrous content of brain and myeloperoxidase ( MPO ) activity in the rat with ischemia and reperfusion of the middle cerebral artery ( IRMCA ) .

利用莎门氏菌B31转化八角茴香中的莽草酸，探讨莽草酸的微生物转化因子。

A new way to obtain shikimic acid ( SA ) through microbial transformation of the bacteria Salmonella B31 in aqueous extracting solution of aniseed residue and its affecting factors were studied .

目的：克隆表达大肠杆菌莽草酸脱氢酶基因aroE，并测定其生物学活性。

Objective : To clone and express aroE gene which encodes shikimate dehydrogenase in Escherichia coli in order to improve the shikimate dehydrogenase product and confirm its new specific activity of quinate dehydrogenase .

异亚丙基莽草酸对血管内皮细胞释放前列环素的影响

Effects of 3,4-oxo-isopropylidene-shikimic acid on the PGI_2 Release in Vascular Endothelial Cell

莽草酸激酶结构域的N-端由三个β折叠组成；

Three β sheets constituted the N-terminus of shikimate kinase ;

大孔吸附树脂对莽草酸粗提液的脱色研究

Research on Decoloration of Shikimic Acid Extract with Macroporous Resin

若干莽草酸衍生物的合成和生物活性研究新编辑手记

Studies on the synthesis and bioactivity of some new shikimic acid derivatives

白扦中莽草酸高效提取纯化的工艺研究

Methodology Research on Effective Extraction and Purification of Shikimic Acid from Picea Meyeri

标记的莽草酸迅速地转变成苯丙氨酸。

Labelled shikimic acid is reality converted to phenylalanine .

响应面法优化莽草酸微波辅助提取工艺

Optimization of microwave assisted extraction process of shikimic acid by response surface analysis methodology

3,4-O-异亚丙基莽草酸晶体结构分析

Analysis of the Crystal Structure of 3,4-Oxo-isopropylidene-shikimic Acid

（－）-莽草酸合成路线图解

Graphical Synthetic Routes of (-) - Shikimic Acid

大肠杆菌莽草酸途径限速酶多基因盒的构建及基因替换

Construction of Rate-Limiting Multigene - Cassette in Shikimate Pathway and Gene Replacement in E.coli

莽草酸含量在贮藏期第一到第三阶段上升，而后略下降；

Shikimic acid level increased from stage one to stage three , then decreased slightly .

活性炭对八角茴香中莽草酸吸附分离性能的研究

Study on Adsorption and Separation Performance of Shikimic Acid from Illicium Verum Hook.f.by Activated Carbon

嘌呤核苷（酸）衍生物的合成及其性质研究莽草酸衍生的新型核苷类似物的合成研究

Synthesis and Properties of Purine Nucleoside and Nucleotide Derivatives ; New Nucleoside Analogues from Shikimic Acid

目前，莽草酸的主要来源是由化学合成或从八角属果实中提取。

Nowadays , the shikimic acid mainly comes from the chemical synthesis or extracting from the Illicium .

高锰胁迫下草甘膦对空心莲子草体内莽草酸含量和抗氧化酶活性的影响

Effects of Glyphosate on Shikimate Content and Antioxidant Enzymes Activity in Alternanthera philoxeroides under High Manganese Stress

莽草酸的研究进展

Research Advance in Shikimic Acid

马尾松、侧柏和八角茴香中的莽草酸含量分析

Analysis on the Content of Shikimic Acid in Masson Pine , Oriental Arborvitae , and Star Anise