草苷

马鞭草苷在不同血浆中蛋白结合率的HPLC测定

Determination of Protein Binding Rates of Verbenalin in Different Plasmas by HPLC

积雪草苷对增生性瘢痕中转化生长因子-βmRNA及基质金属蛋白酶类表达的影响

Effect of asiaticoside on the expression of transforming growth factor-beta mRNA and matrix metalloproteinases in hypertrophic scars

积雪草苷合大黄素对肿瘤坏死因子α诱导的肾系膜细胞C3表达的影响

Effects of Centalla asiatica combining emodin on complement C3 in glomerular mesangial cells stimulated by Tumor Necrosis Factor α

木犀草苷含量测定：确立了金银花木犀草苷含量测定的适宜HPLC参数条件（包括供试品制备方法、流动相的选择、检测波长的选择等）。

Determine the content of galuteolin : Established the HPLC experiment parameters of Lonicera Japonica determination ( the preparation method of samples , the selection of moving phase , The choice of detection wavelength and so on ) .

用体外定向进化的方法对EPSPS合酶基因草苷膦抗性机制的研究

The in vitro directed evolution of EPSPS gene to identify of base pairs related to resistant to glyphosate

目的：研究羟基积雪草苷（madecassoside，MC）对实验小鼠抑郁行为及对大鼠不同脑区单胺氧化酶（Monoamineoxidase，MAO）活性的影响。

Objective : To evaluate the effects of madecassoside ( MC ) on the depression behavior of mice and the activities of monoamine oxidase ( MAO ) in different rat brain regions .

除草试验结果表明：草苷膦、春多多1000倍液对各种杂草有明显的防除效果，30d总防效达92%以上，持效期长；

The weeding test shows that Roundup and glyphosate 1000 times liquid have obvious effect on precaution and weeding . The precaution effect can reach 92 % during 30 days , with long effective period .

结果表明：柚皮苷和新北美圣草苷分别在10～400mg·mL~（-1）和12～480mg·mL~（-1）范围内，线性良好（r≥0.9997）；

A good linearity between peak area and the concentration was found in the range of 10 ~ 400 g mL-1 and 12 ~ 480 g mL-1 for naringin and neoeriocitrin ( r 0.999 7 ), respectively .

积雪草苷对成纤维细胞胶原相关基因的作用

Actions of asiaticoside on human skin fibroblast collagen interrelated genes

积雪草苷对细胞周期和凋亡的影响。

￠ú Effect of asiaticoside on cell cycle and apoptosis .

第三部分是马鞭草苷和戟叶马鞭草苷的结构修饰。

The third part is the structural modification of the two glucosides .

羟基积雪草苷对离体动脉条的舒张作用及其机制

Effects and Mechanisms of Madecassoside on Isolated Thoracic Aortic Rings of Rats

积雪草苷对急性脊髓损伤大鼠神经元损伤保护作用及机制研究

Protective Effects and Mechanisms of Asiaticoside on the Acute Spinal Cord Injury in Rats

积雪草苷对四氯化碳诱导的大鼠肝纤维化的阻断作用

The blocking effects of glucoside of centella asiatica on rat liver fibrosis induced by CCl_4

草苷膦抗性新基因的克隆、序列分析及其蛋白高级结构预测

Cloning , Sequencing and Protein Tertiary Structure Prediction of a Novel EPSPs-encoding Gene with High Glyphosate Tolerance

羟基积雪草苷对小鼠抑郁行为和大鼠不同脑区单胺氧化酶活性的影响

Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats

转基因抗草苷膦大豆对大鼠生理代谢的影响及外源基因水平转移研究

Analysis of the influence on physiological metabolism and genetic horizontal transformation of rats fed Roundup Ready soybean meal

目的本实验室在活性筛选阶段发现积雪草苷具有新的药理活性，初步研究显示其口服生物利用度很低。

Objective : Asiaticoside is a compound which showed new pharmacological activity and good potency but poor bioavailability in rats .

4种黄酮苷的吸收量的顺序为：木樨草苷>忍冬苷>黄芩苷>芦丁。

The uptake of the 4 flavone glycoside is : luteolin-7-O - β - D-galactoside > lonicerin > baicalin > rutin .

制备大鼠原代肝细胞和大鼠肝脏微粒体，研究肝脏中代谢酶对积雪草苷的作用；

The metabolism of asiaticoside was studied in vitro by incubation with rat liver microsomes , hepatocytes and enzymes of intestinal bacteria .

五环三萜类化合物作为皂草苷的糖苷配基在自然界中广泛存在，它们中的许多化合物已被用作传统医学的抗炎药物。

Pentacyclic triterpenes as aglycones of saponins have a wide distribution in plants , many of which have been used in empirical anti-inflammatory therapies .

方法：以积雪草苷提取率为评价指标，采用单因素实验与正交实验设计优选出积雪草中积雪草总苷的提取条件。

Methods : The extraction technique was evaluated by single factor experiment and orthogonal design , with the extraction rate of the asiaticoside as indicator .

修饰超氧化物歧化酶的制备、性质及代谢积雪草苷及其类似物的吸收和代谢性质研究

Study on covalent modification of superoxide dismutase and properties as well as metabolism of its modified form Characterization of Absorption and Metabolism of Asiaticoside and Its Analogs

本研究采用体外、体内、在体和计算机预测等手段对积雪草苷及其类似物的吸收、代谢性质进行研究，以期阐明积雪草苷生物利用度低的原因，并指导进一步的开发。

The purpose of this study was to explore the properties of absorption and metabolism of asiaticoside and its analogs , so as to elucidate the reasons for the poor bioavailability of asiaticoside .

羟基积雪草苷对慢性铝中毒致痴呆小鼠的保护作用2.高胆固醇血症对慢性铝中毒致神经元损伤的促进作用

Protective Effects of Madecassoside on Dementia Induced by the Chronic Aluminum Toxicities to Brain in Mice 2 . Aggravating Effects of Hypercholesterolemia on the Damage to Neuron Induced by the Chronic Aluminum Toxicities in Mice

积雪草总苷元抗抑郁作用机制的初步研究

Studies on the Mechanism of Antidepressant Effect of Centella Triterpenic Genines

结论：积雪草总苷具有抗抑郁活性。

Conclusion : The total triterpenes from Centella asiatica had antidepressant activity .

积雪草总苷对抑郁症大鼠神经内分泌功能的影响

Effects of Centella asiatica total triterpene fractions on endocrine function in depression rats

积雪草总苷缓释片的制备及体外释放特性研究

Study on Preparation of Asiaticosides Sustained-release Tablets and its Release Property in vitro

用酶解预处理-微波法提取积雪草总苷

Extraction of Total Asiaticoside from Centella asiatica by Enzymatic Pretreatment and Microwave Extraction