胆固醇结石

胆囊Ⅲ号方预防胆固醇结石的实验研究

Experimental Research on Prevention of Cholesterol Stone with the Prescription of Gallbladder ⅲ

文章从胆固醇结石与肝脏基因表达关系作一综述。

This paper , from the cholesterol stone and liver gene expression relations are reviewed in this paper .

胆固醇结石、胆囊黏膜和胆汁细菌DNA的检测

Determination of bacteria DNA in cholesterol gallstones , gallbladder mucosa and bile

氨肽酶N在胆固醇结石成因中作用的初步研究

Preliminary study on effect of aminopeptidase N on etiology of cholesterol gallstones

纯胆固醇结石细菌DNA阳性率为100%（3/3）。

Bacteria DNA was positive in all the 3 cases of pure cholesterol gallstone .

基因芯片法检测胆囊胆固醇结石病人肝脏羧肽酶E的表达

Expression of hepatic carboxypeptidase E in patients with cholesterol gallstone

套式聚合酶链反应扩增胆固醇结石中细菌DNA及其临床意义研究

A study on bacterial DNA in Cholesteral gallstones and its clinical significance by NP PCR

载脂蛋白E与胆囊胆固醇结石关系的研究

Apolipoprotein E and cholesterol gallstone formation

结果显示，26例胆固醇结石中有细菌DNA存在。提示细菌可能在胆固醇结石的形成中具有一定的作用。

Bacterial DNA was found in the stones of 26 patients , indicating that most cholesterol gallstones harbor bacterial DNA .

前列腺素E2及粘蛋白在胆固醇结石形成过程中作用机理的探讨

The role of prostaglandin E2 and mucin in formation of cholesterol gallstones

结论PGE2和粘蛋白不是胆固醇结石形成的始动因素，粘蛋白分泌的增加可能是胆囊本身的防护机理。

Conclusions PGE2 and mucin are not the causative factors of cholesterol gallstones .

小肠动力障碍及小肠移行性复合运动（migratingmotorcomplex，MMC）减弱对胆固醇结石形成的影响作用日益受到重视。

The effect of hypomotility of the intestine and longer cycles of the intestinal MMC ( migrating motor complex ) is increasingly recognized on cholesterol gallstone formation .

方法观察胆固醇结石中的细菌在模拟胆汁中的生长活性及其对胆固醇晶体成核时间（NT）的影响。

Methods Observe the bacteria activity in model bile and the influence of bacteria on the cholesterol nucleation time ( NT ) .

多因素分析提示腰/臀比、TT、FINS、空腹血糖为男性胆囊胆固醇结石发病的危险因素。

Multiple regression analysis showed that waist-to-hip circumference ratio , TT , FINS and FBG were the risk factors of cholesterol gallstones , in men .

胆固醇结石患者肝脏LXRα基因的蛋白差异表达及意义

Protein Expression of Liver LXR α Genes in Patients with Cholesterol Gallstone Disease

结论荷叶黄酮可降低肝脏APN的表达和血清LAP，改变血脂水平，从而有助于预防胆囊胆固醇结石的形成。

Conclusion Flavone may prevent the gallstone formation through reducing the expression of APN in liver and LAP in serum and adjusting the lipid level in serum .

PGE2可能从多方面影响胆固醇结石的形成。

The increase of mucin secretion might play a protective role during stone formation , whereas PGE2 could affect the formation of cholesterol gallstones in multiple aspects .

男性胆囊胆固醇结石发病与FT、TT、SHBG呈负相关，与E2/T、空腹胰岛素、HOMA-IR呈正相关。

The incidence of male cholesterol gallstone was negatively correlated with FT , TT and SHBG but was positively correlated with E2 / T , FINS and HOMA-IR .

目的：利用基因芯片和实时定量聚合酶链反应（real-timePcR）分析胆囊胆固醇结石病人肝脏中羧肽酶E（carboxypeptidaseE，CPE）的mRNA表达，探讨CPE与胆囊胆固醇结石形成可能相关的分子机制。

Objective To survey carboxypeptidase E ( CPE ) mRNA expression by cDNA microarray and real-time PCR in the liver of patients with cholesterol gallstone ( CGS ), and to reveal the role of CPE in the formation of CGS .

目的观察CD68在胆囊壁中的表达和分布，探讨其与胆囊壁的脂质转运、胆固醇结石发病之间的关系。

Objective To observe the expression and distribution of CD68 in gallbladder wall and investigate their relationship with the lipid transport of gallbladder wall and cholesterol gallstone .

载脂蛋白AⅠ-CⅢ-AⅣ基因簇XmnⅠ、MspⅠ位点多态性与胆固醇结石病关系的研究

Relation Between Polymorphisms of Xmn ⅰ and Msp ⅰ Sites in Apolipoprotein A ⅰ - C ⅲ - A ⅳ Gene Cluster and Cholesterol Cholecystolithiasis

目的观察胆固醇结石病人和无结石者之间胆囊胆汁中氨肽酶N（APN）活性的变化及熊去氧胆酸（UDCA）对APN活性的影响。

Objective To observe the difference of aminopeptidase N ( APN ) activity in gallbladder bile between patients with cholesterol gallstones and those without them and the effect of ursodeoxycholic acid ( UDCA ) on APN activity .

在33对样本的病例对照配对研究表明目前尚不能肯定胰岛素敏感性在胆囊胆固醇结石发病中的独立风险作用，但糖负荷试验2h胰岛素水平和收缩压升高是胆结石发病的危险因素。

In this case-control study , the effect of insulin sensitivity on the genesis of cholesterol gallstones was not affirmed . However , raised 2h insulin level during glucose tolerance test and systolic blood pressure were risk factors in gallstone formation .

方法采用高糖无脂饲料诱发幼年叙利亚金黄地鼠形成胆固醇结石（CHS），用低蛋白高纤维素饲料诱发成年叙利亚金黄地鼠形成胆色素结石（PS）。

Method The experimental cholesterol gallstones ( CHS ) were conduced in young golden syrian hamsters by a high glucose and fat free lithogenic diet , and the experimental pigment gallstones ( PS ) were conduced in adult golden syrian hamsters with a low protein diet .

目的探讨SR-BI在胆囊胆固醇结石病人胆囊粘膜中的表达和分布，了解其与胆固醇结石发病之间的关系。

Objective To investigate the expression and distribution of scavenger receptor class B type I ( SR-BI ) in the mucosa of patients with cholesterol gallstone , and analyze their relationship .

目的研究胆囊胆固醇结石患者肝脏受体类似物1（LRH-1）表达，探讨其与胆固醇结石病发病的关系。

Objective To investigate the mRNA expression of liver receptor homolog 1 ( LRH-1 ) gene in patients with cholesterol gallstone disease so that to elucidate the biomolecular pathogenesis of gallstone for - mation .

目的：研究胆固醇结石病人BI型清除剂受体（scavengerreceptorBtypeI，SRBI）及其转录调节因子肝脏受体类似物1（liverreceptorhomologue1，LRH-1）的表达，以探讨胆固醇结石发病的机制。

Objective To study the mRNA expression of hepatic scavenger receptor B type I ( SRBI ) and liver receptor homologue 1 ( LRH-1 ) in patients with cholesterol gallstone disease , and to elucidate the bio-molecular pathogenesis of gallstone formation .

目的通过研究胆囊胆固醇结石易成石小鼠（C57L鼠）和抗成石小鼠（AKR鼠）肝脏胆固醇代谢调节酶的基因表达差异来探讨胆囊胆固醇结石形成的分子机制。

Objective To investigate the difference of mRNA levels of hepatic cholesterol ~ metabolism regulatory enzymes between genetically gallstone-susceptible ( C57L ) and resistant ( AKR ) mice for exploring the molecular mechanism of biliary cholesterol hypersecretion and cholesterol gallstone ~ formation .

胆固醇结石病人胆囊胆汁凝血和继发性纤溶亢进的研究

Increased coagulation and fibrinolytic activities in the bile of gallstone patients

多重耐药因子3与胆囊胆固醇结石形成关系的研究

Relationship between the formation of cholesterol calculus and multidrug resistance 3