肺纤维化

早期煤工尘肺患者CT肺纤维化评分与肺表面活性蛋白表达分析

Lung fibrosis C-score and expression of surfactant protein-D in early stage of coal worker pneumoconiosis

结论SiO2可能通过AM的介导影响了FB中MMP-1/TIMP-1系统的表达，参与了肺纤维化的形成。

Conclusion SiO2 may affect the expression of MMP-1 and TIMP-1 system throgh AM mediation and participate in the formation of lung fibrosis .

C型钠尿肽对博莱霉素介导的小鼠肺纤维化的保护作用

Protective effects of C-type natriuretic peptide on bleomycin-induced pulmonary fibrosis in mice

苦参碱对肺纤维化大鼠核转录因子-κB及胶原蛋白Ⅲ的影响

Effect of matrine on NF - κ B and collagen protein ⅲ of rats with pulmonary fibrosis

汉防已甲素对大鼠肺纤维化的逆转作用及其对Ca～（2+）、CaM活性的影响

The Reversion Effect and Affect of Tetrandrine on Pulmonary Fibrosis Organization and Ca2 + 、 CaM in Rat

结果A组肺泡结构正常，B组28d时广泛的肺纤维化为主。

Results Alveolar structure of group A was normal .

特发性肺纤维化患者IL-6水平与T细胞功能的检测

Detection of IL-6 level and T cell 's functions in patients with idopathic pulmonary fibrosis

探讨过氯酸铵（AP）致动物肺纤维化作用。

Objective To explore whether ammonium perchlorate ( AP ) could cause animal pulmonary fibrosis .

在肺纤维化过程中V型胶原的检测可用于评估纤维化病变的预后。

The results indicated that collagen V detection may display a new sign for evaluation of pathological changes of lung fibrosis .

用RT-PCR方法动态分析博莱霉素致肺纤维化大鼠TGF-β1的基因表达

Dynamic Analysis of TGF - β _1 Gene Expressions in Bleomycin-Induced Pulmonary Fibrosis in Rats by RT-PCR

系统性硬皮病肺纤维化HRCT表现与病程的关系

Pulmonary Fibrosis in Systemic Sclerosis : Correlation between HRCT Findings and Disease Duration

结论在肺纤维化早中期，肺间质成纤维细胞高表达MMP-2。

Conclusion mRNA expression of MMP - 2 in fibroblasts are up-regulated in fibrosis silicotic model rats .

目的：动态观察博莱霉素致肺纤维化大鼠间质巨噬细胞（IM）释放IL-1和TNFα的变化。

Objective : To study the interstitial macrophages ( IMs ) release of IL-1 and TNF α in pulmonary fibrosis rats .

盐酸博莱霉素致大鼠肺纤维化动物模型HRCT的评价

Evaluation the diagnostic value of HRCT in a rat model of pulmonary fibrosis induced with bleomycin A5

STAT1对实验性肺纤维化大鼠肺组织炎症的调控作用

Regulative Effect of STAT_1 on Inflammation of Lung Tissue in Bleomycin-induced Rat Interstitial Pulmonary Fibrosis

特发性肺纤维化（IdiopathicPulmonaryFibrosis，IPF）是特发性间质性肺炎（Idiopathicinterstitialpneumonia，IIP）中最常见的类型，病理表现为普通型间质性肺炎。

Idiopathic pulmonary fibrosis is the most common type of idiopathic interstitial pneumonia with the histologic appearance of usual interstitial pneumonia .

复方鳖甲方能改善肺纤维化大鼠的HRCT影像，降低肺组织纤维性病变。

CBF could improve HRCT images of the lung in the model rats and reduce pulmonary fibroid change .

结论：HT合剂可能通过保护血管内皮细胞和肺泡上皮细胞以及抑制胶原生物合成起到对肺纤维化的防治作用。

Conclusion : CHTM could through protect the vascular endothelial cells and alveoli epithelial ceils to prevent and treat pulmonary fibrosis .

喘消雾化液对博莱霉素诱导大鼠肺纤维化模型IL-8、TNF-α水平的影响

The effects of chuan-xiao-wu-hua-ye on the level of IL-8 and TNF - α in serum and BALF of bleomycin-induced fibrosis in rats

在第4周时，博莱霉素组为典型的Ⅲ～Ⅳ级肺纤维化表现。目的探讨慢性阻塞性肺病（COPD）与胶原蛋白前提、胶原蛋白前提关系。

Objective To study the relationship between chronic obstructive pulmonary disease ( COPD ) and Procollagen ⅰ Peptidase ( PIP ) , Procollagen ⅲ Peptidase .

特发性肺纤维化（IdiopathicPulmonaryFibrosis，IPF）是间质性肺疾病（interstitiallungdisease，ILD）的代表性疾病，以肺泡炎、肺间质纤维化为病理特点。

Idiopathic pulmonary fibrosis ( IPF ) is the representative disease of interstitial lung disease ( ILD ) . Its pathologic characters are alveolitis and pulmonary interstitial fibrosis .

本研究旨在通过不同时期运用外源性IL-10对博来霉素诱导的肺纤维化大鼠进行干预，探讨外源性IL-10对肺纤维化的作用机理。

This experiment is to investigate the effect of IL-10 on bleomycin-induced pulmonary fibrosis in rats by administrating exogenic IL-10 at its different stages .

结论肺纤维化患者血清PCⅢ、CⅣ及PLD的水平可作为反映肺纤维化改变的参考指标。

Conclusion The above results suggest that the levels of PC ⅲ, C ⅳ and PLD in the serum may be used as an effective reference index in diagnosing the pulmonary fibrosis .

结果CPT能显著减轻肺泡炎和肺纤维化的程度，肺泡间隔宽度、BALF中细胞数和总蛋白水平可间接反应肺组织的损伤程度。

Width of alveolar septa and cell number and protein content in BALF could indirectly reflect injury degree of lung tissue .

UIP并肺纤维化是药物反应性肺损伤的常见表现。

UIP with lung fibrosis is a common pattern of drug-related lung injury .

基质金属蛋白酶（MMPs）是调节细胞外基质降解的一组重要蛋白酶，对肺纤维化的形成有重要作用。

Matrix metalloproteinases ( MMPs ) play important roles in the regulation of the ECM degradation and the development of pulmonary fibrosis .

反义TIMP-1基因转染对博来霉素诱导的肺纤维化大鼠TIMP-1和MMP-2表达的影响

The Effect of Antisense-human TIMP-1 ( hTIMP-1 ) TIMP-1 Transfection on the Expression of and MMP-2 in the Lungs of Rats with Pulmonary Fibrosis Induced by Bleomycin

Ⅳ型胶原酶也称为明胶酶（gelatinase），包括MMP-2和MMP-9，在小鼠肺纤维化过程中起重要作用。

Type IV Collagenase ( also called gelatinases , including MMP-2 and MMP-9 ), is very important in the progression of pulmonary fibrosis in mice .

特发性肺纤维化（IPF）临床以进行性呼吸困难为特征，与中医所论短气相似。

Idiopathic pulmonary fibrosis is clinically characterized by progressive dyspnea and is similar to shortness of breath described in TCM .

结论VEGF持续高表达与大鼠血管内皮细胞损伤有关，而血管内皮细胞的损伤可能是BLM诱发大鼠肺纤维化的重要启动因素之一。

Conclusion The high expression of VEGF is related to vascular endothelial cells injury which may be one of important factors in the formation of bleomycin-induced pulmonary fibrosis .