维库溴铵

注射用维库溴铵的RP-HPLC测定

Determination of vecuronium bromide for injection by RP-HPLC

目的：探讨新型麻醉剂咪唑安定、异丙酚、维库溴铵在大容量全肺灌洗术（WLL）中的应用效果。

Objective : To observe the effect of the new-type anesthetic Midazolam , propofol , vecuronium bromide during the process of whole-lung lavage ( WLL ) .

输注PRO，酌情静注芬太尼、维库溴铵维持麻醉。

Anesthesia was maintained with PRO and intermittently intravenous fentanyl , vecuronium .

结果初量罗库溴铵的起效时间为（198±047）min，明显短于维库溴铵的（325±082）min。

Results The onset time of rocuronium was ( 1.98 ± 0.47 ) min , which was faster than that of vecuronium ( 3.25 ± 0.82 ) min.

存在伤害性刺激时（如气管插管），即使小剂量（0.03mg/kg）的维库溴铵也可降低脑电熵指数和BIS的升高幅度。

Vecuronium even a relatively small dose ( 0.03 mg / kg ) can reduce the degree of increase in SE , RE and BIS values induced by noxious stimulation such as tracheal intubation .

目的观察单次静注不同剂量国产维库溴铵（Vec）的肌松效应，组胺释放作用及其对血流动力学的影响，评估该药用于全麻诱导时的肌松效应及安全性。

Objective This study was to observe the neuromuscular blocking effects , histamine release and haemodynamic changes of different doses of domestic vecuronium in the induction of general anesthesia .

根据手术时间必要时可单次追加维库溴铵0.05mg/kg熏芬太尼1μg/kg。

During the operations , Vecuronium 0.05mg/kg and Fentanyl 1 μ g / kg were again administered intravenously only one time in case necessary .

异丙酚3mg/kg，维库溴铵0.1mg/kg～0.15mg/kg静脉注射诱导气管插管。

After anesthesia induction with Propofol 3mg / kg and Vecuronium 0.1 mg / kg ~ 0.15 mg / kg intravenously , the baby was intubated .

麻醉诱导期：静注咪唑安定0.06mg/kg、芬太尼3ug/kg、维库溴铵0.12mg/kg、依托咪酯0.35mg/kg。

Anesthesia induction period : intravenous midazolam 0.06mg / kg , fentanyl 3ug / kg , vecuronium 0.12mg / kg , etomidate 0.35mg/kg .

P组采用咪唑安定0.04mg/kg、芬太尼4μg/kg、维库溴铵0.1mg/kg和靶控异丙酚麻醉诱导，靶浓度为4.0μg/ml。

In the group P anaesthesia was induced with midazolam 0.04mg / kg , fentanyl 4 g / kg , vecuronium 0.1mg/kg and target-controlled infusion of propofol with target concentration was 4.0ug/ml . Endotracheal intubation was performed and mechanical ventilation began .

静脉注射咪达唑仑0.05mg/kg，芬太尼4μg/kg，丙泊酚2mg/kg，维库溴铵0.1mg/kg诱导行气管插管。

Induced tracheal intubation by intravenous injected midazolam 0.05 mg / kg , fentanyl 4 μ g / kg , propofol 2 mg / kg , vecuronium bromide 0.1 mg / kg .

每搏指数在插管后5min下降了13.5%～19.5%，每搏量下降了11.3%～23.8%，明显低于维库溴铵组。

Whereas SI decreased by 13.5 % - 19.5 % and SV decreased by 11.3 % - 23.8 % during 1-4 min after intubation ( T3-6 ) as compared with the baseline , significantly lower than those in vecuronium group .

方法：30例全麻病人根据不同预处理药分成3组，即0.9%生理盐水（对照组）；0.01mg/kg维库溴铵组和0.05mg/kg阿曲库铵组，每组10例。

Methods : Thirty adult patients under gener-al anesthesia were randomly divided into three groups according to the pretreatment agent used : 0.9 % NaCl ( control ) , 0.01 mg / kg vecuronium and 0.05 mg / kg atracurium .

方法：重度硫丹中毒患者12例，按治疗方法分为两组，治疗组5例，用维库溴铵注射液0.03～0.06mg·kg1·h1静脉微泵维持5～28h；

Methods : Twelve suitable patients were randomized into two groups . Five cases in the treatment group received injection of vecuronium bromide 0.03 ~ 0.06 mg · kg - 1 · h - 1 by micro-pump maintaining for 5 ~ 28 h.

用硫喷妥钠5mg/kg、维库溴铵地0.1mg/kg静注后气管插管，随后连接Astiva3000型麻醉机测定气道阻力、肺顺应性和气道压。

Anesthesia was induced with thiopental ( 5 mg / kg ) and vecuronium ( 0 . 1 mg / kg ) . Patients were intubated and mechanically ventilated ( Astiva 3000 , Ohmeda ) . Airway resistance , pulmonary compliance , and airway pressure were measured .

咪唑安定0.04mg/kg、异丙酚1.5mg/kg、芬太尼4μg/kg、维库溴铵0.12mg/kg静脉诱导后，甲组给予尼卡地平4μg/kg，乙组给予生理盐水3ml作为对照。

After venous induction with midazolam 0.04mg / kg , propofol 1.5mg / kg , fentanyl 0.3 mg / kg , vecuronium bromide 0.12mg / kg , patients in group A received nicardipine 4 μ g / kg , normal saline 3ml in group B , catheter was inserted .

结论缩短预注间隔至1min，并不减小罗库溴铵对其后维库溴铵的预注效应，在顺序使用罗库溴铵和维库溴铵的预注方法中，缩短预注间隔至1min是可行的。

Conclusion Reducing the priming interval to 1 minute would not eliminate the effect of rocuronium priming on the followed Vecuronium . It is feasible to shorten the priming interval to 1 minute in : the priming principle using Rocuronium and Vecuronium successionally .

周期节律对维库溴铵神经肌肉阻滞作用的影响

Effects of Periodic Rhythm on Neuromuscular Block by Vecuronium Bromide

预注维库溴铵行快速诱导气管内插管的临床观察研究

Clinical Research of Rapid Tracheal Intubation with the Priming Vecuronium

维库溴铵在肝移植患者中的药代动力学研究

Study on Pharmacokinetics of Vecuronium in Recipients of Liver Transplantation

吸入不同浓度的七氟烷对维库溴铵肌松效应的影响

Effect of sevoflurane of different concentrations on vecuronium muscle relaxation

大黄和维库溴铵救治急性毒鼠强中毒的临床研究

A clinical study on rhubarb and vecuronium bromide in acute tetramine intoxication

汽水瓶颈上的粉末残留物证实是维库溴铵

Powder residue on the neck of the soda bottle shows Vecuronium --

这一结果经荧光法进行了验证维库溴铵（肌可松）

The results are proved by fluorescence with the characteristics of ethidium bromide .

维库溴铵在急性颅高压气管插管术前的应用

Application of Vecuronium Bromide for Patients with Acute Intracranial Hypertension Before Endotracheal Intubation

罗库溴铵和维库溴铵应用于快速气管插管的时效比较

Comparison of rocuronium and vecuronium for rapid endotracheal intubation

食道癌手术患者靶控输注与间断静注维库溴铵的药效学研究

Study on Pharmacodynamics of TCI and intermittent intravenous Vecuronium in esophageal carcinoma operating

用芬太尼、异丙酚和维库溴铵静脉注射诱导后行气管内插管。

These patients were induced and intubated with Fentanyl , Vercurium , Propofol iv.

顺式阿曲库铵、维库溴铵在老年患者中的药效学研究

Pharmacodynamics of cisatracurium and vecuronium in elderly patients

单次或持续静脉输入维库溴铵作用时效比较

Comparison of Pharmacokinetics between Bolus and Continuous Vecuronium