细胞内受体

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  • intracellular receptor
细胞内受体细胞内受体
  1. 通过干扰配体/受体的相互作用、抑制激酶的催化活性以及阻断细胞内受体/效应分子间的相互作用等方式,可以显著抑制Met受体活化及其介导的下游信号通路。

    Impairment of Met receptor activity signaling can be achieved via antagonism of ligand / receptor interaction , inhibition of TK catalytic activity , and blockade of intracellular receptor / effector interactions .

  2. 环鸟苷酸(cGMP)依赖的蛋白激酶(PKG)是一氧化氮-cGMP的主要细胞内受体,在哺乳动物细胞中分为PKG-I和PKG-II两型。

    CGMP-dependent protein kinase ( PKG ) is the major intracellular receptor for cyclic guanosine monophosphate ( cGMP ) . Two forms of PKG , PKG-I and PKG-II , occur in mammalian tissues .

  3. 细胞内受体介导亲脂性信号分子的信息传递,如胞内的甾体类激素受体。

    Cell receptor-mediated lipophilic signal molecule in the transmission of information , such as cell within the steroid hormone receptors .

  4. 15000Dal蛋白质前人未有报道。它对腺苷具有高度特导性和亲和力,推测是腺苷的细胞内受体和/或载体。

    The 15,300 Dal protein has not been reported previously and possibly is an intracellular receptor and / or carrier for adenosine .

  5. 三通道荧光共振能量转移分析法的优化及其对活细胞内受体复合物组成的分析生物大分子相互作用检测技术新进展&三色荧光级联荧光共振能量转移技术

    OPTIMIZATION OF THREE-CUBE FRET ASSAY AND APPLICATION IN THE ANALYSIS OF SUBUNIT ASSEMBLING OF iGluR RECEPTORS IN LIVING CELLS A Progress in Detection of Interactions Between Macromolecules : Linked FRET Using Three Color Fluorophore

  6. 长期以来,可溶性细胞内雌激素受体ERα/β(ER)一直被认为是其作用的唯一受体。

    For a long time , soluble intracellular estrogen receptor ER α / β( ER ) has been considered to the only receptor for its role .

  7. 雌性大鼠成骨细胞内雌激素受体表达的研究

    The estrogen receptor expression in osteoblast of female rats

  8. 催乳素对大鼠前列腺上皮细胞内雄激素受体和5α-还原酶活性的影响

    Effect of prolactin on androgen receptor and 5 α - reductase activity in rat

  9. 去势与非去势不同月龄雌性大鼠成骨细胞内雌激素受体β的表达特点

    Expression of estrogen receptor beta in osteoblasts of ovariectomized rats and non-ovariectomized rats of different months

  10. 生长调节剂对生物体的调控作用是通过调节剂与生物体细胞内的受体蛋白相互作用来实现的。

    The regulation effect of growth regulator is realized by the interaction between receptive proteins in organism .

  11. 成骨细胞内雌激素受体检测:应用半定量蛋白印迹酶促底物染色法以及发光法。

    Level of estrogen receptors was detected with semi-quantitative Western blot and luminescent method to measure the value of A.

  12. 介绍使用电镜确定细胞内雌激素受体位置的微波制样新技术。

    This paper introduced a new technique of sample preparation localizing intracellular estrogen receptor for electron microscopy by microwave irradiation .

  13. 目的建立一种灵敏度高、特异性强的细胞内雌激素受体检测方法。

    Objective : To find a highly sensitive and specific method by which estrogen receptor in cells can be assayed .

  14. 如这类反应是发生在雌激素依赖性肿瘤细胞内的雌激素受体上,可能会有抑制肿瘤生长的作用。

    If these reactions occurred on the estrogen receptors in the cells of estrogen-dependent tumors , the growth of tumors may be inhibited .

  15. 此外,Gβγ对细胞内定位,调节受体功能,活化磷脂酶Cβ,影响受体激酶和腺苷酸环化酶活性等都起到重要作用。

    In addition , G βγ dimers plays important roles on the intracellular localization , regulating receptor function , influencing the activities of phospholipase C β, receptor kinase , and adenylate cyclase .

  16. 人参皂苷对人肝细胞HL-7702内性激素受体水平的影响

    Effect of Ginsenoside on Level of Sex Hormone Receptors in Human Liver Cell Line HL-7702

  17. 目的:探讨TGF-β对WB鼠肝脏上皮细胞内Ⅰ型IP3受体表达的影响。

    Objective : To investigate the effect of TGF - β on the expression of type ⅰ inositol 1,4,5-triphosphate receptor in WB rat liver epithelial cells .

  18. 结论1,25(OH)2D3能刺激髁突软骨细胞内三磷酸肌醇受体(IP3R)钙释放通道开放,使细胞内钙离子水平显著升高;

    Conclusion 1,25 ( OH ) - 2D-3 could stimulate the intracellular calcium release channel of inositol triphosphate ( IP3 ) receptor open in MCC in vitro and increases the level of intracellular calcium concentration .

  19. 当该蛋白质复合物正常发挥作用时,它使这些受体退回到神经细胞内-在此这些受体无法接受或响应有利突触生长的信号-在合适的时间内。

    When the protein complex is working properly , it moves the receptors back inside the nerve cell-where they can no longer receive and respond to the pro-growth signal-at the appropriate time .

  20. 结果表明,DEHP和DBP可诱导MCF-7细胞增殖、细胞内雌激素受体水平增高,对细胞周期无明显影响,DEHP不引起断乳大鼠子宫增重。

    DEHP and DBP could induce MCF-7 cell proliferation and increase the level of estrogen receptors in the cell , did not influence markedly the cell cycle and induce the rat uterotropic .

  21. 方法通过加入不同的试剂浓度及改变细胞渗透剂等,观察细胞内雌激素受体的表达。

    Methods : The level of estrogen receptor was estimated by varying antibody concentrations and different cell membrance permeability agents .

  22. 采用免疫组化和医学图像分析系统相结合的方法,测定各组大鼠胃窦及十二指肠5-HT细胞的数目、面积、平均灰度、细胞内5-HT含量及5-HT受体阳性细胞内5-HT受体的含量。

    The immunohistochemistry and MIPS were used to measure 5HT cell number , square , mean grey level and the contents of 5HT and 5HT receptor in their positive cells in every rat 's gastric antrum and duodenum .

  23. 树突细胞(Dendriticcell,DC)识别上皮细胞或黏膜表面的抗原,通过其细胞内受体或吞噬细胞受体捕获它们,经加工处理后转移至淋巴组织。

    Dendritic cell ( DC ) survey epithelial or mucosal surfaces for antigens , take them up via their endocytic or phagocytic receptors , process the captured antigens and migrate to the lymphatic tissues .

  24. 3种凝集素受体在胃癌与非癌胃粘膜细胞的电镜定位显示:阳性标记金颗粒主要定位于细胞膜相结构;胃癌细胞内凝集素受体表达明显增强,粘液泡内出现密集分布的阳性标记金颗粒。

    The electron microscopic localization of 3 lectin receptors showed that positive gold particles were mainly localized on membrane structure of cells , that expression of lectin receptors in gastric cancer cells was enhanced obviously .