硫鸟嘌呤

一种简易检测人红细胞中6-硫鸟嘌呤浓度的HPLC法

A Simple and Rapid HPLC Method for Determination of 6 - Thioguanine Concentration in Human Leukemic Cells

目的探讨巯基嘌呤甲基转移酶（TPMT）活性、基因型和硫鸟嘌呤核苷酸（TGNs）浓度检测对6巯基嘌呤（6MP）化疗个体化的意义。

Objective To evaluate the activity and genotype of thiopurine methyltransferase ( TPMT ) and the concentration of thioguanine nucleotides ( TGNs ) as parameters for individualizing mercaptopurine ( 6-MP ) therapy .

RP-HPLC测定硫鸟嘌呤片的含量及有关物质

Determination of Tioguanine and Its Related Substances by RP-HPLC

8-氮杂鸟嘌呤衍生物的合成新方法与性质研究RP-HPLC测定硫鸟嘌呤片的含量及有关物质

Studies on Novel Synthesis and Properties of 8-Azaguanine Derivatives ; Determination of Tioguanine and Its Related Substances by RP-HPLC

巯基嘌呤甲基转移酶活性和硫鸟嘌呤核苷酸浓度检测在6-MP个体化化疗中的意义

Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy

6-硫鸟嘌呤治疗溃疡性或不确定性结肠炎：一项前瞻性、公开标识试验

A prospective , open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis

硫鸟嘌呤核苷酸浓度检测在儿童急性淋巴细胞白血病6-巯嘌呤个体化疗中的意义

Significance of TGNs detection for individualizing 6-MP chemotherapy in children with acute lymphoblastic leukemia

6&硫鸟嘌呤对大鼠性腺的影响

Effect of 6-Thioguanine on Rat Sexual Gland

同步扫描-导数-固体基质室温燐光法同时测定痕量2,6-二氨基嘌呤和硫鸟嘌呤的研究

Simultaneous Determination of Trace of 2 , 6-Diaminopurine and Thioguanine by Synchronous Derivative Solid Substrate Room Temperature Phosphorimetry

目的：建立一种快速、灵敏、高效的方法，检测儿童急性淋巴细胞白血病红细胞中硫鸟嘌呤核苷酸浓度。

Objective To establish a HPLC method to measure thioguanine nucleotides concentration in children with acute lymphoblastic leukemia .

结论：在优化条件下，本方法测定硫鸟嘌呤核苷酸快速、准确、灵敏度高。

CONCLUSION : Under optimized conditions , HPLC method for the determination of thioguanosine is fast , accurate and sensitive .