硫酸鱼精蛋白

HL-P体外显著延长家兔TT、APTT、PT的最低浓度分别为1.0μg/ml、0.8μg/ml、8.0μg/ml，其抗凝效应可为硫酸鱼精蛋白所纠正，说明HL-P具有一定的安全性。

Minimal HL-P concentrations which prolonged TT , APTT , PT significantly were 1.0 , 0.8 , 8.2yg / ml , respectively . The anticoagulative action could be corrected by protamine sulfate . It indicated that HL-P was a kind of safe medicine .

结论：硫酸鱼精蛋白注射液细菌内毒素检查是可行的。

Conclusion : Test for bacterial endotoxins of protamine sulfate injection may be conducted for its quality control .

人用纯化Vero细胞狂犬病疫苗中硫酸鱼精蛋白残留量的测定

Residue detection of protamine sulfate from purified Vero-cell rabies vaccines used for human

结果：LPS、EGF+TNF-α和硫酸鱼精蛋白均可抑制GEC掺入[3H]-TdR，并呈一定的量效和时效关系；

RESULTS : LPS , protamine sulfate , TNF - α and EGF could significantly inhibit the - TdR incorporation of GEC in a dose - and time-dependent manner .

菲立磁-硫酸鱼精蛋白复合物标记大鼠骨髓间充质干细胞的实验研究

Labeling of feridex-protamine sulfate complexes into murine mesenchymal stem cells

目的：建立硫酸鱼精蛋白注射液细菌内毒素的检查方法。

Objectives : To set up the bacterial endotoxins determination method for Protamine Sulfate Injection .

结果表明随着硫酸鱼精蛋白浓度的增大，量子点荧光强度逐渐降低。

The results showed that the fluorescent intensity of CdTe QDs decreased when the concentration of protamine sulfate increased .

目的：对硫酸鱼精蛋白注射液进行细菌内毒素检查的可行性研究，为该药品质量标准中制定内毒素检查项提供参考。

Object : To study the test for bacterial endotoxins in protamine sulfate injection and provide reference for its quality control .

结果：硫酸鱼精蛋白注射液（10mg/ml）在稀释240倍时无干扰作用，可用细菌内毒素检查法进行检查。

Results : Diluted by BET-water for 240 times of protamine sulfate injection ( 10 mg / ml ), the injection showed no signs of interfering factors for its test for bacterial endotoxins .

用1.0A强度的超声波和5%的硫酸溶液提取鱼精蛋白，提取时间20min，能得到较高活性的鲤鱼抗菌精蛋白。

Protamine of higher antibacterial activity could be extracted with 1.0 A ultrasound , 5 % H_2SO_4 for 20 min.