硝酸酯类

用导管法评定硝酸酯类药物对中心动脉压的影响

The Effect of Nitrates on Central Aortic Pressure by Cannulation

硝酸酯类药物对高血压患者大动脉顺应性的影响

Effect of Nitrates Administration on Large Artery Compliance in Patients with Essential Hypertension

常规治疗组的治疗措施为抗血小板、硝酸酯类药物、强心、利尿剂、急诊PCI等。

The treatments in the latter group included anti-platelet , nitrates , cediland , diuretics and emergent PCI .

硝酸酯类药停减率A组为88.2%，B组为27.8%，2组比较，差异有非常显著性意义（P<0.01）。

The withdrawal medicine rate of esters nitrate was 88 . 2 % and 27 . 8 % in group A and B respectively ( P < 0 . 01 ) .

方法观察16例AMI患者经过冠状动脉成型术，以及肝素、硝酸酯类药物、阿斯匹林等治疗前后血清VEGF的变化。

Methods Serum VEGF was measured in16 AMI patients undergoing angioplasty and receiving medical treatment with heparin , isosorbide dinitrate , and aspirin .

目的观察硝酸酯类药物对老年单纯收缩期高血压（ISH）患者脉压（PP）的影响。

Objective To investigate the effect of nitric acid ester on pulse pressure ( PP ) in elderly patients with isolated systolic hypertension ( ISH ) .

服用硝酸酯类药物、抗血小板药物的患者ED的发生率高（66.7%，59.5%），与未服用者（43.7%，40.0%）比较，差异有显著性意义（P均<0.01）。

There were significant differences in the incidence of ED between patients treated with nitrates and antiplatelet drugs ( 66.7 % , 59.5 % ) and those without ( 43.7 % , 40.0 % )( P < 0.01 ) .

结论硝酸酯类药物能降低ISH患者的SBP，而对DBP影响不大，能使PP减小，对老年ISH患者降压治疗有益。

Conclusions Nitric acid ester can decrease SBP in ISH and has less effect on DBP , leading to decreasing in PP which is beneficial to elderly .

目的采用硝酸酯类药物介入心肌断层显像，用存活心肌定量分析结果评价溶栓和PTCA治疗AMI的效果。

Objective To evaluate the effect of intravenous thrombolysis and PTCA in treatment of acute myocardial infarction ( AMI ) using viable myocardium quantitative analysis on 99m Tc MIBI myocardial perfusion SPECT imaging .

II3和II9的抗炎活性与DC相当，II2的抗炎镇痛活性强于DC，胃肠道副作用小于DC，并小于文献报道的硝酸酯类NODC，体内有明显的NO释放。

Compounds II 3 and II 9 showed anti inflammatory activity comparable to DC . Compound II 2 showed stronger anti inflammatory and analgesic activities and less GI side effect than DC , and released NO in vivo .

心功能级别、病变部位、高血压、利尿剂、洋地黄制剂、硝酸酯类、血管紧张素转换酶抑制剂（ACEI）及β-阻滞剂对生存有影响。

The heart function , lesion site , hypertension and the treatment of diuretics , digitalis , nitride , ACEI and β - blocker had a significant influence on survival .

结论：HBO可引起与NTG连续应用相似的耐受性，表明氧化应激血管组织O2-产物升高是硝酸酯类耐受性形成的重要机制；

Conclusion : Continuous administration of NTG and HBO exposure can result in development of NTG tolerance in rats . which may be related to the O2 - increase in vascular tissues .

常规治疗组30例，根据病情常规应用洋地黄、利尿剂及硝酸酯类药物。缬沙坦治疗组30例，在常规治疗组基础上加用缬沙坦80mg／日。

Half of the patients were treated with conventional method with digoxin , diuretics and nitric acid ester , the other half with ARB 80mg / day in addition to conventional treatment .

近十年随着内皮源性舒张因子（EDRF）的研究进展，硝酸酯类的抗血小板作用逐渐被验证。目前的研究表明，P-选择素是一种膜糖蛋白，储存在血小板的。

In recent 10 years , with the development research of endothelium - derived relaxing factor ( EDRF ) , the antiplatelet function of organic nitrates has been test and verified .

患者入院后均常规给予口服阿司匹林、硝酸酯类药物、β受体阻滞剂、血管紧张素转换酶抑制剂（ACEI）或血管紧张素Ⅱ受体抑制剂（ARB）、他汀类及改善循环药物。

After admission , patients were routinely given oral Aspirin , nitrates , beta blockers , angiotensin-converting enzyme inhibitor drugs ( ACEI ) or angiotensin ⅱ receptor blockers ( ARB ) class of drugs , statins and improve circulation drugs .

结果：利尿剂、强心苷、ACEI及硝酸酯类药分占1～4位，使用率均超过58%，其它类药使用率低于50%。

RESULTS : The use of diuretic , cardiac glycosides , ACEI and nitrate rank from 1 st to 4 th respectively , all of them are more than 58 % , while the using rate of other kinds of medicine are less than 50 % .

对照组在改善生活方式，控制心血管疾病危险因素，积极治疗导致缺血性心肌病形成的原发疾病基础上，应用利尿剂、强心甙、ACEI、β受体阻滞剂、硝酸酯类、他汀类药物等西药常规治疗。

In the control group in improving life style , the control of cardiovascular disease risk factors , active therapy cause ischemic cardiomyopathy form based on the primary disease , application diuretics , cardiac glycosides , ACEI , p blockers , nitrates , statins and other routine western medicine .

目的探讨阿魏酸硝酸酯类药物非拉尼特（FLNT）对大鼠缺血-再灌注心肌的保护作用及其机制。

Objective To probe into the protective effect of ferilnite ( FLNT ), a drug belonging to the class of ferulic acid nitric ester , on the myocardium submitted to ischemia / reperfusion injury in rats .

硝酸酯类药物临床应用中若干问题的探讨

Exploration of some Problems in Clinic Application of Nitrate Esters

对照组112例，常规用抗凝、硝酸酯类等药治疗。

Control groups : patients was112 with frequent treatment ( nitriteasprit ) .

超氧阴离子与硝酸酯类药物耐药硝酸酯类药物不同途径给药后的药动学比较

Comparison of pharmacokinetics of nitrates in different administrations

硝酸酯类药物临床应用

Clinical usage of drugs belonging to ester nitrate

3种硝酸酯类静脉注射液的制剂质量分析

Quality analysis of three isosorbide nitrate intravenous injections

硝酸酯类药对大鼠蛛网膜下腔出血后脑血管痉挛影响的研究

The influence of mononitrate ester healer on vasospasm and cerebral ischemia after SAH in rats

硝酸酯类的生物转化及其耐受机制的研究进展

Progresses in nitrate biotransformation and tolerance mechanisms

各部位心肌细胞对硝酸酯类药物预适应能力的实验研究

Preconditioning effect of nitrate medicine on different parts of the heart and its signaling pathway

卡托普利增强硝酸酯类药物对冠心病心衰疗效的研究

A study of captopril enhancement of nitrate effect coronary arterial disease patients associated with heart failure

药物治疗组有稍微更多的倾向服用钙通道阻滞剂和止痛的硝酸酯类药物。

The drug therapy group was slightly more likely to hae taken calcium-channel blockers and pain-killing nitrates .

硝酸酯类药物联合传统降压药有助于老年单纯收缩期高血压患者血压控制。

Nitrates had a role as an adjunct in the anti-hypertensive therapy of elderly patients with isolated systolic hypertension .

硝酸酯类药物可增加冠脉缺血区的血流量，增强缺血区的节段收缩，从而达到抗心肌缺血、抗心绞痛的作用。

They can increase blood flow in the coronary ischemia area so that they have the functions of anti-myocardium-ischemia and anti-angina-pectoris .