特异性免疫应答

PML-RARα融合基因及其诱导特异性免疫应答

PML-RAR α Fusion Gene and Its Ability for Specific Immune Response Induction

B（7-2）表达质粒对HBVdna疫苗诱导的特异性免疫应答的影响

Effect of B_ ( 7-2 ) expression plasmid on the specific immune response induced by HBV DNA vaccine

B细胞表位基因疫苗诱导特异性免疫应答及特性研究

Characterization of immune response of DNA vaccine encoding B cell epitope

乙型肝炎病毒核心区DNA疫苗接种后H-2~d小鼠的特异性免疫应答

Specific immune responses in H-2 ~ d mice after DNA immunization of HBV core gene

免疫应答的产生首先由抗原提呈细胞（antigen-presentingcell，APC）摄取抗原，经其加工、处理后将信息传递给淋巴细胞，引发一系列特异性免疫应答。

The first step of immune response is antigen-presenting cell ( APC ) intape antigens .

乙肝治疗性免疫疫苗就是根据诱生机体特异性免疫应答来清除HBV病毒的原理而成为研究热点。

Therapeutic hepatitis B vaccines can induce the production of the specific immune response in order to suppress HBV virus .

树突状细胞（Dendriticcells，DC）是目前已知的功能最强的专职可以递呈细胞，具有激活初始T细胞增殖的独特功能，是特异性免疫应答的启动因素。

Dendritic cells ( DCs ) are currently known to be the most potent professional antigen-presenting cells , which have the unique function of stimulating naive T cells .

目的观察异位hCGβ基因免疫诱导的肿瘤特异性免疫应答及其抗肿瘤作用，为肿瘤的免疫生物治疗寻求新途径。

Objective To investigate the specific anti tumor immunity induced by gene immunization with ectopic hCG encoding gene .

jejuni多价DNA疫苗。并探讨其在小鼠体内诱导特异性免疫应答的效应和在小鼠C。

Jejuni polyvalent DNA vaccine with effective mucosa immune response , explored the specific immune responses and immunoprotection in mice challenged with C.

体外表达的Glypican-3的CTL表位肽诱导特异性免疫应答

Specific immune responses induced by CTL epitope peptides of Glypican-3 expressed in vitro

可以肯定，随着人们对DNA疫苗免疫机制深入理解以及提高其诱导特异性免疫应答水平经验的积累，DNA疫苗定会在预防动物各种疾病方面发挥巨大作用。

With the gradual apprehension profundity about DNA immunomechanism and the experiments accumulations of enhancing DNA vaccine immunity responsion , it can be affirmed that DNA vaccine must exert great function on defending animals free of diseases .

靶向DC-SIGN的抗原特异性免疫应答研究

Research on Antigen-Specific Immune Response after Targeting Antigen to DC-SIGN

bcr-abl融合基因真核表达载体诱导小鼠特异性免疫应答

Recombinant eukaryotic expression plasmid of bcr-abl gene fragment induces specific immune re - sponse in mice

胃癌、食管癌中NY-ESO-1抗原特异性免疫应答与生存率的关系研究

Antigen expression and cellular immunogenicity of NY-ESO-1 in gastric and esophageal cancer

结论HCV多表位基因可诱发特异性免疫应答且安全性好，为HCV疫苗的研究提供了一定的理论及实验依据。

Conclusion The multiple epitope antigen gene of HCV could induce specific immune responses without obvious toxicity and it might be able to serve as an effective HCV vaccine candidate .

目的：观察由编码HBsAg与HCV-CE2抗原的两种重组真核细胞表达质粒制备的DNA疫苗重复联合接种BALB/c小鼠后，其诱生的特异性免疫应答反应。

Objective : To study the immune response after a mixed DNA vaccine of two kinds of eukaryotic expression plasmids encoding HBsAg and HCV CE 2 was singly inoculated to the BALB / c mice .

在外源性抗原的加工提呈途径中，抗原肽与MHCⅡ类分子的结合是激活辅助性T细胞特异性免疫应答的先决条件。

In the exogenous antigen processing and presentation pathway , peptide binding MHC class ⅱ molecule is an important prerequisite for activating helper-T-cell mediated immune response .

已有研究提示，包括特异性免疫应答在内的多种机制在中国EIAV毒疫苗诱导免疫保护中起作用。

Previous studies have revealed that multiple mechanisms including specific immunity contribute to the protection .

并用重组抗原和真核重组DNA质粒分别免疫动物，观察其诱导产生的特异性免疫应答反应，探讨其作用机制，并通过对鸡只攻击E.tenella的保护作用检测其抗球虫效果。

In order to observe the induced specific immune response , the recombinant antigen and eukaryotic recombinant DNA plasmids were immunized animals to gain the protective effect .

IL-15基因已经在一些实验中被用作基因疫苗佐剂，取得了良好的促进抗原特异性免疫应答的效果。

IL-15 has been used in some experiments as an adjuvant and has significantly enhanced the induction of Ag-specific immune responses .

结论成功地构建了MAGE-1基因疫苗，该疫苗能够有效地诱导特异性免疫应答。

Conclusion : The gene vaccine of MAGE-1 is constructed successfully and it can induce specific immunological responses effectively .

在特异性免疫应答方面，HBV和HCV感染后机体清除病毒的途径主要有特异性CTL细胞的杀伤作用、CD4+细胞的辅助作用、抗体的中和作用或杀伤作用。

For adaptive immune responses , the main approaches to clear viruses after HBV and HCV infections are the killing effects of CTL with assistance of CD4 + cells and the neutralization or killing effects of antibodies .

结论：卵巢癌相关抗原OVA66的HLAA2限制性CTL表位L235，能激发对肿瘤抗原的特异性免疫应答，为制备肿瘤特异性肽疫苗奠定了实验基础。

CONCLUSION : This novel OVA66-derived CTL epitope L235 can induce HLA-A2-restrictive CTL response , which lays the foundation for preparation of tumor-specific peptide vaccine .

结果发现：（1）CPGDNA和乳酸杆菌能够显著增加小肠树突状细胞的数量，刺激树突状细胞的活性，促进局部疫苗抗原的递呈，有效诱导局部黏膜的特异性免疫应答。

Our results showed that ( 1 ) significantly increased numbers of DC in intestine were found in CpG DNA and LAB. It demonstrated that adjuvants could activate DC , promote antigen presenting and induce specific immune responses in local mucosa .

免疫反应的发生首先是由抗原提呈细胞（Antigen-presentingcells，APC）捕获抗原，经其加工、处理将抗原信息提呈给T、B淋巴细胞，从而启动一系列的特异性免疫应答。

The induction of antitumor immunity is a multi-step process , which includes the capture and processing of tumor antigen by antigen presenting cells ( APC ), selection and activation of antigen-specific T cells , then recognition and attacking of effector lymphocytes to the tumor cells .

TNF／TNFR超家族成员中的CD40／CD40L、OX40／OX40L分子因其在特异性免疫应答中的重要作用和与疾病的密切关系而备受瞩目，成为免疫学中的热点研究领域。

Co-stimulators CD40 / CD40L and OX40 / OX40L , which belong to TNF / TNFR super family , play an important role in immunology response and have a close relation to serious disorders such as autoimmune disease and cancer .

特异性免疫应答在真菌性角膜炎发病和转归中的作用

The Role of Adaptive Immunity in the Pathogenesis of Fungal Keratitis

抗原基因修饰的树突状细胞诱导机体产生特异性免疫应答的实验研究

Induction of specific antitumor immune responses by vaccination with tumor antigen gene modified dendritic cells

硬骨鱼类是同时拥有非特异性免疫应答与特异性免疫应答的最原始脊椎动物。

Teleost fish are the most primitive vertebrates with both non-specific and specific immune response .

乙型肝炎病毒全S基因疫苗诱导小鼠的特异性免疫应答

Specific Immune Responses Against Hepatitis B Virus Following Immunization with the DNA Vaccine Containing HBV pan-S Gene in Mice