毒杀芬

毒杀芬对孤儿受体雌激素相关受体1（ERRα-1）的拮抗作用

The antagonists of ERR α - 1 orphan receptor : toxaphene

结论毒杀芬是ERRα1的拮抗剂，它拮抗了ERRα1调节芳香族化酶转录的作用，从而使该酶的表达量降低。

Conclusion Toxaphene is the antagonist of ERR α 1 . It antagonize the regulation of aromatase activity and decrease the expression of aromatase .

DNA合成抑制试验在毒杀芬25mg/Kg（1/4LD（50））剂量对小鼠DNA合成有明显抑制作用，从上述三种诱变试验结果来看作者认为毒杀芬具有潜在性的诱变作用。

Toxaphene inhibited DNA synthesis in mice of the 25mg / kg ( 1 / 4 LD 50 ) group . These results have illustrated the potential mutagenicity of toxaphene .

毒杀芬为有机氯杀虫剂的一种，残效期长。

Toxaphene , an organic chloride insecticide possesses a long residual period .

毒杀芬成分复杂，性质特殊，目前已经广泛滞留于环境中。

Toxaphene is one of the POPs with complex composition , special properties and widely distributing in the environment .