毒蕈碱

结论：ECL细胞上存在胃泌素、生长抑素和毒蕈碱受体。

Conclusions : There are receptors of gastrin , somatostatin and muscarine on the ECL cell surfaces .

胃泌素、生长抑素、毒蕈碱和氨对组胺分泌的影响

Influences of Gastrin , Somatostatin , Muscarine and Ammonia Liquid on Secretion of Histamine

培养人角膜缘上皮细胞和角膜基质成纤维细胞中存在编码毒蕈碱受体1-5亚型的mRNA。

The message RNA for m1-5 was found in the cultured human limbal epithelial cells and corneal fibroblasts .

地塞米松对哮喘豚鼠气管平滑肌毒蕈碱受体mRNA的表达及肺泡灌洗液嗜酸性粒细胞浸润的影响

Effects of dexamethasone on the expression of muscarinic receptor mRNA in asthmatic guinea pig airway smooth muscle and eosinophil infiltration in bronchoalveolar lavage fluid

蛋白激酶C激动剂可以抑制上述反应，提示介导卡巴胆碱诱发钙离子稳态变化的毒蕈碱样胆碱能受体可以被PKC负性调节。

PKC agonist could inhibit the responses indicating that muscarinic receptors mediating the carbachol-induced intracellular calcium mobilization were negatively regulated by intracellular PKC .

方法：利用亲和层析方法从猪脑中纯化毒蕈碱乙酰胆碱M2受体；

Methods : The acetylcholine M_2 muscarinic receptors were purified from porcine brain by single step affinity chromatography .

从培养的角膜缘上皮细胞和角膜基质成纤维细胞中提取总PNA和蛋白质，行毒蕈碱受体1-5亚型RT-PCR和westernblot。

RT-PCR , western blot and immunofluorescent staining for m1-5 were carried out on cultured limbal epithelial cells and corneal fibroblasts .

毒蕈碱型M5受体亚型及生物学特性

Muscarinic M 5 receptor subtype and its biologic characterizations

目的观察吗啡依赖大鼠脊髓和脑干毒蕈碱型乙酰胆碱受体m1～5的表达。

AIM To observe mRNA expression of muscarinic acetylcholine receptors in spinal cord and brainstem in morphine dependent or withdrawal rats .

NOS抑制剂和MK-801对吗啡依赖大鼠脊髓和脑干毒蕈碱型受体表达的影响

Effects of NOS inhibitor and NMDA receptor antagonist on the expression of muscarinic receptors in spinal cord and brainstem during morphine withdrawal in rats

目的：观察脑震荡（Brainconcussion，BC）大鼠毒蕈碱型M1、M2受体和烟碱型N受体的变化规律，进一步了解BC大鼠认知行为障碍的神经生物学基础。

Objective : To observe the changes of Ml , M2 and N acetylcholine receptors following brain concussion ( BC ) in rats and research the neurobiology mechanisms of cognitive behavioral deficits after BC .

目的从舟山眼镜蛇Najaatra蛇毒中分离毒蕈碱样多肽，探讨其与M胆碱受体的关系。

Objective To isolate muscarinic peptide ( MP ) from Naja atra venom and to study the effect of MP in muscarinic cholinergic receptor ( mChR ) .

在预试验时发现，阿托品（0.1μm）为测定NAF所必需，所以在后来的所有测定中都在灌流液中加入这种毒蕈碱拮抗剂。

Under these conditions , atropine ( ATR , 0.1 μ M ) appeared requisite for NAF ; thus this muscarinic antagonist was subsequently added to all perfusion buffers .

M受体即毒蕈碱样乙酰胆碱受体，属G蛋白耦联受体，现已确认有5种亚型（M1-M5）。

Muscarinic acetylcholine receptors are members of the huge superfamily of G-protein-coupled receptors ( GPCRs ) . To date , five pharmacologically distinct receptor subtypes ( M1-M5 ) have been defined .

胆碱能神经在胃肠运动的神经调控中起重要作用，通过释放乙酰胆碱，作用于胃肠道ICC细胞膜胆碱能毒蕈碱受体（cholinergicmuscarinicacetylcholinereceptors，CHRM）进一步影响平滑肌的收缩。

Cholinergic nerves play an important role in neural regulation of GI motility by releasing acetylcholine binding to cholinergic muscarinic acetylcholine receptors ( CHRM ) on ICCs , which causes contractions of smooth muscles .

目的研究有机磷类杀虫剂（OPs）对G蛋白结合受体激酶-2（GRK-2）介导的毒蕈碱乙酰胆碱M2受体（mAChR2）磷酸化的影响，进一步揭示OPs可能存在的其他作用途径。

Objective To explore the effect of organophosphorus insecticides ( OPs ) on G protein-coupled receptor kinase 2 mediated phosphorylation of M2 muscarinic receptors in vitro and to understand an alternative target of the OPs for human and other animals .

目的：研究人角膜缘和角膜、结膜是否表达毒蕈碱受体1-5亚型（m1-5）。

Purpose : To characterize in human limbus , cornea and conjunctiva the expression of muscarinic receptors ( m1-5 ) .

ACh对离体豚鼠心房肌细胞APD的脱敏有浓度依赖性与时间依赖性；脱敏的发生可能与毒蕈碱型胆碱能受体及Ik，ACh电流有关。

CONCLUSION : The effect of desensitization on APD to ACh in atrial cells is concentration and time dependent , these effects may be related to the change of the muscarinic receptor and the potassium channel .

实验结果提示：下丘NE水平的提高减弱AS，NE可能是作用于下丘内与外周α2-NE能受体相似的受体而抑制AS的。下丘毒蕈碱样受体的激活对AS起促进作用。

The results suggest : The elevation of the level of NE in the inferior colliculi reduces the severity of audiogenic seizures , the inhibitory effect of NE on audiogenic seizures is attributable to an action on a receptor similar to the peripheral alpha-2 adrenergic receptor .

这种抑制作用可以被毒蕈碱胆碱受体（M受体）拮抗剂阿托品和东莨菪碱，或选择性M4受体拮抗剂托吡卡胺所阻断，但是，阿片受体拮抗剂纳洛酮则不能阻断这种作用。

This inhibitory effect was blocked by atropine or scopolamine , a muscarinic acetylcholine receptor ( mAChR ) antagonist , or tropicamide , a selective M4 mAChR antagonist , while naloxone , an opioid receptor antagonist had no effect .

目的研究不同毒蕈碱受体亚型（M4，M5）对吗啡诱发大鼠奖赏效应的影响，同时观察腹侧背盖区（ventraltegmentalarea，VTA）神经型一氧化氮合酶（nNOS）表达的变化。

Aim To investigate the roles of different muscarinic receptors ( M 4 , M 5 ) subtype on rewarding effects induced by morphine and the changes of neuronal nitric oxide synthase ( nNOS ) expression in ventral tegmental area ( VTA ) of rats .

毒蕈碱受体在人角膜缘和角膜、结膜表达的研究

Expression of Muscarinic Receptors on Human Limbus , Cornea and Conjunctiva

麻醉剂氟烷对心脏毒蕈碱型钾通道的影响

Effect of halothane on the muscarinic potassium current of the heart

西方蜜蜂毒蕈碱型乙酰胆碱受体基因的生物信息学分析

A bioinformatics analysis on the Apis mellifera muscarinic acetylcholine receptor gene

毒蕈碱样乙酰胆碱受体及其拮抗剂在近视发生发展中的作用

Mechanism of muscarinic acetylcholine receptors and antagonists to myopia development

毒蕈碱样乙酰胆碱受体m1~m5亚基在大鼠前庭终器组织中的表达

Expression of mACh receptor m1-m5 subunits in the vestibular endorgans of rat

毒蕈碱型M1受体的同源模建和分子对接

Homology Modeling and Molecular Docking on Muscarinic M_1 Receptor

毒蕈碱1型受体在人视网膜色素上皮细胞表达的研究

C shape ; Expression of muscarinic acetylcholine receptor-1 in human retinal pigment epithelium

人结肠平滑肌毒蕈碱受体亚型的研究

Subtypes of Muscarinic Receptor in Human Colonic Smooth Muscle

烟碱对大脑皮层毒蕈碱型受体与其激动剂和拮抗剂结合的调节

Modulation by nicotine on binding of cerebral muscarinic receptors