最大耐受剂量

结果：此天然抗氧化剂经小鼠急性毒性试验，最大耐受剂量大于8g/kg·BW，属无毒物质；

Results : BSB extract was a substance with no toxicity according to the acute toxicity test ( MTD > 8g / kg · BW ) .

目的探索不同剂量方克（替加氟）联合草酸铂治疗胃肠道癌的最大耐受剂量（MTD）和剂量限制性毒性（DLT）。

Objective To determine the maximum-tolerated dose ( MTD ) and dose-limiting toxicity ( DLT ) of tegafur and oxaliplatin in patients with gastrointestinal cancers .

本研究目的是探讨同时持续静脉滴注CF与5-FU，人体对5-FU的最大耐受剂量（maximumtolerateddose，MTD）及剂量限制性不良反应。

The purpose of this article was to study the maximum tolerated dose ( MTD ) and the dose limiting toxicity ( DLT ) of human body to simultaneously intravenous infusion of 5 FU and CF.

目的探讨希罗达对鼻咽癌增敏放疗的剂量限制毒性（DLT）和最大耐受剂量（MTD），同时观察疗效。

Objective To evaluate the dose-limiting toxicity ( DLT ), efficacy and maximum tolerated dose ( MTD ) of capecitabine with concurrent radiotherapy in patients with node-positive stage ⅱ nasopharyngeal cancer .

其剂量限制毒性（DLT）为中性粒细胞减少和腹泻，肝肾功能下降会降低最大耐受剂量（MTD）。

The dose limiting toxicity ( DLT ) o f it was neutropenia and diarrhea . Its maximum tolerance dose ( MTD ) may be reduced by elevated liver or kidney function .

方法采用最大耐受剂量（MTD）试验和大鼠30d喂养试验，分别观察了麻软胶囊的急性毒性和亚急性毒性。

Methods The maximal tolerable dose ( MTD ) of rat to gastrodia softgel and 30-day feeding tests on rat were performed . The acute toxicity and subacute toxicity of rats to gastrodia softgel were also observed .

结果其最大耐受剂量LD50分别大于2,16,75g/kg（相当于推荐临床试用剂量的500～5000倍），观察14天未见小鼠和大鼠死亡。

Results The dosage of utmost tolerance LD 50 was larger than 2,16,75g / kg ( about 500-5000 times more than recommended clinical dosage ) . During the observation period of 14 days , there was no death report .

本研究旨在考察肿瘤患者对rhLTα-Da的耐受性，确定人体的最大耐受剂量（MTD），推荐Ⅱ期临床试验剂量。

This study was to evaluate the tolerance of tumor patients to rhLT α - Da , confirm its maximum tolerable dose ( MTD ) in vivo , and to provide recommending dose for phase ⅱ trial .

d-1的剂量。结论美托洛尔在常规治疗心力衰竭基础上能显著改善患者临床症状及心功能，能否加至最大耐受剂量，有赖于应用技巧。

CONCLUSION : Administration of metoprolol plus the conventional therapy for heart failure significantly improved the clinical symptoms and cardiac function in patients with CCHF , but whether the normal dose could be increased to maximum tolerated dose depends on the administration technique .

这篇论文主要研究的是第Ⅰ阶段临床试验中最大耐受剂量的估计问题。

In this paper , the estimation of the maximum tolerated dose of a drug for phase I clinical trials is investigated .

结果：大鼠阴道给予黄体酮药膜一天的最大耐受剂量为400mg/kg；

Results : The maximal tolerant dose of progesterone pellicle in one day , by vaginal injection , was 400mg / kg ( LD 50 > 400mg / kg );

对家兔耳静脉注射该产品后未见毒副反应，测得其最大耐受剂量为4mL/kg体重。

Rabbits were not found any toxic side effects after injecting the product into their eye Vein , and their most tolerable dosage is 4 ml / kg body weight .

第Ⅰ阶段临床试验的主要目的就是估计人体对研究新药的最大耐受剂量，确保Ⅱ期试验科学、有效地进行。

The main purpose of phase I clinical trials is to estimate the maximum tolerated dose of a new drug which will be passed for further testing in phase II trials .

研究结果显示，家蚕雌蛾粉具有明显的抗氧化作用。（3）采用最大耐受剂量法，检测家蚕雌蚕蛾粉急性毒性作用。

The results showed that female moth silkworm powder has obvious anti-oxidation . ( 3 ) Maximum tolerated dose was used to detect acute toxic effects of female silkworm moth powder powder .

本文研究的是在第一阶段临床试验中，寻找两种制剂混合而成药物的最大耐受剂量的方法。

In this paper , the author want to probe the method how to find one or more acceptable drug dose combinations of two agents used together in a Phase I clinical trial .

最大耐受剂量定义为10例患者中有至少有8例患者能耐受剂量限制毒性（≥Ⅲ级的放射性损伤）。

The maximum tolerated dose ( MTD ) was defined as the dose that more than 8 of 10 patients could tolerate the dose-limiting toxicity ( DLT )( grade ≥ⅲ radiation injuries ) .

传统的肿瘤化疗方案一般是采用最大耐受剂量间隔较长时间（如2-3周）给药，以确保人体正常组织在给药间隔期间得以适当的修复。

Traditional tumor chemotherapy is generally known as the maximum tolerated dose therapy using a longer time interval ( eg 2-3 weeks ) administration to ensure that human normal tissues in the interval between administrations could recover .

方法对100例心力衰竭患者在常规心衰治疗基础上加用美托洛尔，逐渐加量至靶剂量（最大耐受剂量），目标分别为①心率下降至55~60次/分。

METHODS Patient treatment foundation adds to 100 examples heart the failure in conventional heart in the failure with metoprolol , slowly the increment to intratarget dosage , the goal respectively is : 1.The heart rate drops to 55 ~ 60 / minute .

方法全组25例，在切除胃肠道肿瘤的同时，应用微泵技术，最大耐受剂量，对原肿瘤供血区域的动脉主干插管置泵灌注化疗，同时进行预防肝转移的肝动脉插管置泵化疗。

Methods Pump controlling perfusion chemotherapy with micropump technique and maximal tolerant dosage applied was performed in 25 cases of gastrointestinal cancer being resected by inserting catheter through the main artery supplying blood to the region of the tumors as well as hepatic artery to prevent hepatic metastasis .

分析注药后SPECT显像、裸鼠体内放射性分布、外周血细胞、血肝肾功能和组织病理变化研究最大药物耐受剂量和最适剂量。

To searching for MTD and optimum dose through analyzing SPECT scintigrams , radioactivity concentration in bodies of nude mice , peripheral blood cells ( PBC ), Hepatic function , renal function and the pathological change of normal tissues .

在胆管最大安全耐受剂量50Gy时，经胆管192Ir内照射有效的治疗范围可达15mm。

Within the safest endurance limit of 50 Gy the effective irradiation field could reach 15 mm from the involved bile duct .

IMRT减少了脊髓最大受照剂量和平均受照剂量，较3D-CRT降低了脊髓的受量。且两者有统计学差异（P0.05）但两种计划均未超出脊髓的最大耐受剂量。

IMRT can significantly decrease the maximum exposure dose and average exposure dose to the spinal cord compared with 3D-CRT ( P 0.05 ), but neither of the two plans exceed the maximum tolerance dose of spinal cord .