昆布糖
- 名laminariose
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昆布多糖的提取分离及F1的纯化与鉴定
Studies on extraction and isolation of polysaccharides from laminaria and purification and identification of F_1
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目的:研究昆布多糖硫酸酯(LAMS)对急性髓性白血病HL-60细胞株的调控作用。
Objective : To study the effects of LAMS on modulation of HL-60 cell strain .
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目的观察硫酸昆布多糖(laminarinsulfate,LS)对仓鼠胰腺癌肝转移模型的抑制效果,阐明其抑制肿瘤机制。
Objective To investigate the inhibiting effect of laminarin sulfate ( LS ) in hamster model of liver metastasis of pancreatic cancer and explore its mechanism .
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昆布多糖(Laminarin)是昆布属、海带属等植物中含有的一种多糖类成分。
Laminarin is a polysaccharide composition contained in the genus Laminaria and other plants .
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结果表明,昆布多糖最佳水浸提工艺条件为温度90°C、加水量60倍、浸提时间4h,多糖得率可达18.31%。
The results show that the optimum extraction process was : extraction temperature of 90 ℃ , water to-talling of sixty times , extraction duration of 4 h. The yield of polysaccharide was 18.31 % .
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结果昆布多糖硫酸酯对HL-60细胞增殖有抑制作用,随着昆布多糖硫酸酯浓度的增加其抑制程度增强,在3.125μg/ml浓度下抑制作用达到最强;
Rasult : With the increase of LAMS concentration , the inhibiting effects on multiplication of HL-60 cell were increased . it is the most effects at 3.125 μ g / ml.
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方法建立仓鼠胰腺癌肝转移模型,利用三种不同剂量LS对实验各组进行干预,应用昆布多糖、生理盐水作为对照组;
Methods After the hamster model of liver metastasis of pancreatic cancer was established , LS of 3 different dosages was given to animals in 3 experimental groups and sodium laminarin and normal saline were given to the animals in the 2 control groups , respectively .
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昆布多糖提取工艺及理化性质分析
Optimizing extraction process and physicochemical property analysis of Ecklonia polysaccharide
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昆布多糖对大鼠骨髓巨噬细胞生物活性的影响
Effect of laminarin on bioactivity of bone marrow macrophage
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硫酸昆布多糖在仓鼠胰腺癌肝转移模型中抑制作用的研究
Inhibiting effect of laminarin sulfate in hamster model of liver metastasis of pancreatic cancer
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结论硫酸昆布多糖对肿瘤生长、转移、血管生成有明显抑制作用。
Conclusions LS can significantly inhibit growth , metastasis and angiogenesis of pancreatic cancer .
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在试验期内昆布多糖能明显改善高血糖大鼠的糖耐量,而对血清胰岛素水平的影响不明显。
TLP could significantly improve diabetic rat 's dose of sugar endurance , while had no obvious effect on the level of serum insulin .
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酚氧化酶原显著地受血浆和昆布多糖同时存在的激活,但两者单独存在时对酚氧化酶原的激活作用较弱。
The ProPO was significantly activated by laminarin present in the plasma due to a much higher PO activity than that when the laminarin or the plasma was tested alone .
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目的:对昆布多糖进行硫酸酯化,并对产物的纯度与结构进行分析,为研究其生物活性奠定物质基础。
Objectives : To sulfate the laminarin , then analyze the purity and elucidate the structure of polysaccharide sulfate , so as to make a foundation for the further research about its biological activity .