新生霉素

新生霉素对人肝癌细胞的抑制作用

Antitumor effect of novobiocin on patients'primary liver cancer cells

目的研究新生霉素的抑制血管生成作用及其机制。

Aim To study the anti angiogenic activity of novobiocin and its mechanism of action .

新生霉素抑制拓扑异构酶Ⅱ对多瘤病毒DNA合成的影响

Effect of Novobiocin-mediated Inhibition of Topoisomerase ⅱ on Polyomavirus DNA Synthesis

目的研究新生霉素的结构单元诺维糖和香豆素的抗肿瘤活性。

Objective To study the antitumor activity of otiose and coumarin in novobiocin .

分子量77kD，pI7.3。新生霉素和香豆霉素A1不抑制酶活性。

The molecular weight was 77 kD and the isoelectric point was 7.3 . Novobiocin and coumermycin A1 had no effects on the activity .

这些致病菌对环丙沙星、新生霉素等药物有很高的敏感性，而对青霉素、链霉素、杆菌肽和多粘菌素已经产生耐药性。

Those pathogens were susceptible to ciprofloxacin and novobiocin , however resistance to penicillin G , streptomycin , bacitracin and polymyxin B was produced .