托吡酯

大剂量维生素B2联合托吡酯预防偏头痛发作的半随机对照研究

Controlled clinical trial of high-dose Vitamin B_2 combined with Topiramate in the prophylaxis of migraine

托吡酯对偏头痛的长期预防作用：Pivotal试验的开放标记扩展研究

Long-term migraine prevention with topiramate : Open-label extension of pivotal trials

托吡酯（Topiramate）一种新型抗癫痫药抗疱疹病毒药缬昔洛韦

Topiramate : a novel antiepileptic drug a novel antiherpetic drug & valaciclovir

小剂量托吡酯治疗Tourette综合征疗效观察

Effect of low-dose topiramate on Tourette syndrome

小剂量托吡酯添加治疗儿童Tourette综合征的临床观察

Clinical study on the additive therapeutic effect of low-dose Topiramate in children with Tourette syndrome

神经生长因子和托吡酯对红藻氨酸致痫大鼠海马神经细胞caspase-3表达的影响

Effect of nerve growth factor and topiramate on the expression of caspase-3 in the hippocampus in rats with kainic acid induced seizures

托吡酯与氟哌啶醇治疗Tourette综合征临床对照观察

The comparison study of the therapeutic effect of topiramate and haloperidol in children with Tourette syndrome

4用对点燃无明显影响剂量的尼卡地平2mg／kg与托吡酯50mg／kgig合用，缩短点燃大鼠的后放电时程（P＜0.05）；

( P < 0.05 ) 4 The combination of ineffective doses of topiramate 50 mg / kg ig and nicardipine 2 mg / kg ip shortened ADD .

目的研究丙戊酸钠（VPA）对托吡酯（TPM）神经保护作用的影响。

Objective To study the influence of valproate sodium ( VPA ) on neuroprotective effects of topiramate ( TPM ) .

这说明在T2DM动物模型中，托吡酯同时有胰岛素促泌剂和胰岛素增敏剂作用。

It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models .

目的：定量观察托吡酯（TPM）对戊四氮（PTZ）点燃大鼠脑电图（EEG）的影响。

Aim : To observe the effect of topiramate ( TPM ) on quantitative EEG ( qEEG ) of pentylenetetrazol ( PTZ ) - kindled rats .

托吡酯治疗Lennox-Gastaut综合征24例远期疗效观察

Long-Term Effect of Topiramate Treatment on 24 Cases of Lennox-Gastaut Syndrome

目的：观察妥泰（托吡酯topiramate，TPM）治疗癫疒间的效果、剂量及安全性。

Objective : A clinical trial was conducted to observe the effect , dosage and security of topiramate ( TPM ) therapy for epilepsy .

目的：探讨戊四氮（PTZ）点燃大鼠海马结构白细胞介素-6（IL-6）表达的特征及托吡酯（TPM）对其表达的影响。

Aim : To explore the effects of topiramate ( TPM ) on the expression of interleukin-6 ( IL-6 ) in the hippocampus of pentylenetetrazol ( PTZ ) kindling rats .

目的：探讨中等剂量托吡酯（商品名：妥泰）200mg对特发性全面性强直阵挛（GTCS）发作的疗效。

Objective : To study the curative effect of middle dose of topiramate ( 200mg ) on general tonic clonic seizure .

目的观察托吡酯（TPM）对急性脑梗死患者血清神经元特异性烯醇化酶（NSE）及神经功能的影响，探讨TPM对急性脑梗死的作用。

Objective To look at the effects of Topiramate ( TPM ) on serum neuron-specific enolase ( NSE ) and neurological impairment scale in patients with acute middle cerebral artery infarction .

目的：观察新型抗癫痫药托吡酯（妥泰）单药治疗癫痫的临床疗效和24h动态脑电图（AEEG）变化。

Objective : To observe the clinical efficacy of topiramate ( topamax ) which was a new anti-epileptic drug and the change of 24h ambulatory electroencephalography ( AEEG ) in the patients with epilepsy .

目的探讨托吡酯单一或联合治疗Lennox-Gastaut综合征（LGS）的疗效及不良反应。

Objective To explore the effect and adverse reaction of topiramate ( TPM ) on treating Lennox-Gastaut syndrome ( LGS )( including therapeutic alliance or single ) .

目的采用不同剂量的托吡酯治疗27例儿童原发性全身强直阵挛性癫痫（GTCS）的长期开放性研究。

Objective To study the long-term therapeutic effect of Topiramate ( TPM ) in the treatment of idiopathic generalized tonic-clonic seizure ( GTCS ) in children .

Teva制药工业有限公司股份有限公司，公司Mylan华生药品和其他非专利药制定者也出售药品在化学名称托吡酯治疗。

Teva Pharmaceutical Industries Ltd , Watson Pharmaceuticals Inc , Mylan Inc and other generic drug makers also sell the drug under its chemical name topiramate .

目的：观察红藻氨酸（KA）致痫大鼠海马caspase-3表达情况，探讨神经生长因子（NGF）和托吡酯（TPM）对KA致痫大鼠脑神经细胞的保护作用。

Objective : To observe the expression of caspase-3 in hippocampus of epileptic rat induced by kainic acid ( KA ), and explore the neuroprotective effect of Topiramate ( TPM ) and nerve growth factor ( NGF ) to epileptic rat induced by kainic acid .

1目的利用戊四氮（PTZ）慢性癫痫点燃模型，研究托吡酯（TPM）是否对海马碱性成纤维细胞生长因子（bFGF）表达以及海马齿状回苔藓纤维出芽（MFS）有影响作用。

Objective The study is aim to determine whether topiramate ( TPM ) has an effect on bFGF expression in hippocampus and moss fiber sprouting ( MFS ) in dentate gyrus with a chronic kindling rat model by pentetrazole ( PTZ ) .

在一月份，Vivus说FDA希望公司来评估可行的，可取得的资料分析确定风险唇腭裂的腭裂在婴儿从女人以托吡酯治疗。

In January , Vivus said FDA wanted the company to assess how feasible it would be to analyze available data to determine the risk of cleft lip and cleft palate in infants from women taking topiramate .

在难治性癫痫大鼠模型中，托吡酯以及托吡酯和丙磺舒联合治疗可以对海马神经元起保护作用，可以使GFAP表达减弱，两治疗组间表达GFAP星形胶质细胞的数目和积分光密度无统计学差异。

In the rat model of intractable epilepsy , topiramate and topiramate plus probenecid treatment can both protect hippocampal neurons , weakening GFAP expression . However , there is no statistical difference between the numbers of positive cells and integrated optical density in the two treatment groups . 3 .

结果：托吡酯组治疗6mo的继发性全身发作，简单及复杂性部分发作有效例数优于丙戊酸钠组，4例在加药期快时出现疲劳、嗜睡、注意力不集中等。

RESULTS : Simple and complex partial seizures with or without secondary generalized seizure , in topiramate group were much more improved than these in sodium valproate group 6 mo after treatment .

对于复方药VI-0521（含有苯丁胺和托吡酯两种成分），低剂量组个体体重平均下降8.46%，而高剂量组个体体重平均下降9.21%。

For VI-0521 , subjects in the lower-dose combination group lost an average of8.46 % of their body weight , and those in the higher-dose combination group lost an average of9.21 % .

通过观察癫痫患者血小板膜PBRs改变、癫痫大鼠发作行为和不同脑区PBRs的变化以及托吡酯（TPM）的干扰作用，探讨PBRs对癫痫敏感性的影响。

In order to explore the role of PBRs in seizure susceptibility , changes of PBRs in platelet membrane from epilepsy patients , seizure behaviors and PBRs levels in different brain areas in epilepsy rats and anticonvulsant actions of topiramate ( TPM ) were investigated .

方法：60例躁狂发作病人分为2组，托吡酯组30例给予托吡酯，开始剂量25mg·d-1,2wk内逐渐增加至100～400mg·d-1；

METHODS : Sixty inpatients with manic episode were divided into topiramate or carbamazepine group . Thirty patients of topiramate group were treated with topiramate 25 mg · d - 1 at first , then increased gradually to 100 ~ 400 mg · d - 1 for 6 wk .

托吡酯还显著降低血压和尿蛋白排泄。

Topiramate also significantly reduced blood pressure and urinary albumin excretion .

应用肌电图评估托吡酯治疗面肌痉挛的效果

Electromyogram in assessing the effect of topiramate therapy for facial spasm