慢性哮喘

结论：用OVA致敏、激发，可以成功建立小鼠慢性哮喘模型。

The research established the chronic asthma model of mice .

结论：止喘胶囊（补肾健脾法）可能通过减少气道壁胶原和Fn沉积，抑制慢性哮喘的气道重建，有利于对慢性哮喘的治疗和预防。

Conclusion : ZCC could inhibit the remodeling of airway in chronic asthma by way of reducing the precipitation of collagen and Fn , thus help the prevention and treatment of chronic bronchial asthma .

结果慢性哮喘气道重塑组血清Ca浓度高于正常对照组（P<0.05），Mg、P浓度低于正常对照组（P<0.05）；肺脏重量/体重、脑重量/体重明显高于正常对照组（P<0.01）。

Results In the airway remodeling group , the content of calcium in serum was higher , magnesium and phosphorus were lower , the ratio of lung , brain and body weight was higher than that in the normal control group .

人重组磷脂酶D2对小鼠小胶质细胞表达IL-1β和TNF-α以及对豚鼠慢性哮喘模型相关因子的调控

Modulation and Effect of Recombinant Human Phospholipase D 2 on the Expressions of IL-1 β and TNF - α in Activated Microglia and Asthmatic Relevant Factors in Guinea-pigs Attacked by Asthma

OVA组、MT组和DXM组卵蛋白（OVA）致敏并反复雾化吸入OVA2周、4周及8周，造成慢性哮喘模型，LUZ组OVA致敏后雾化吸入OVA2周；

Group OVA , MT and DXM were sensitized and repeatedly challenged with ovalbumin ( OVA ) for periods of 2,4 and 8 weeks to establish a murine model of chronic asthma .

结论：慢性哮喘小鼠出现气道重建，早期使用地塞米松可以预防气道重建，降低BALF中TGF-α的浓度、抑制肺组织EGFR的表达和活化。

CONCLUSION : Airway remodeling occurs in the chronic mice asthma model . Early dexamethasone injection can inhibit the expression and activation of EGFR system ,( decrease ) the TGF α concentration in BALF and prevent the airway remodeling .

目的观察褪黑素（MT）与褪黑素受体拮抗剂Luzindole（LUZ）对小鼠慢性哮喘模型中气道炎症和气道重构的影响。

Objective To investigate the effects of melatonin ( MT ) and its receptor antagonist luzindole ( LUZ ) on airway inflammation and airway remodeling in a murine model of chronic asthma .

胸导管引流对慢性哮喘病人外周血淋巴细胞内环核苷酸代谢的影响

Effect of TDD on lymphocyte cyclic nucleotide metabolism in chronic asthma

慢性哮喘豚鼠及其在低氧干预下海马脑区超微结构的变化

Ultrastructural changes of hippocampus in guinea pigs with chronic asthma and the effects of hypoxia treatment

慢性哮喘豚鼠气道重塑血清电解质及主要脏器/体重的变化

Changes of Electrolyte and Ratio of Organ and Body Weight in Airway Remodeling of Chronic Asthmatic Guinea Pig

呋塞米吸入治疗对老年慢性哮喘患者肺功能和外周血T淋巴细胞亚群的影响

Effect of inhaled furosemide on pulmonary function and T lymphocyte subsets in peripheral blood in aged patients with chronic asthma

目的：通过小剂量致敏原反复致敏建立豚鼠慢性哮喘模型，设定不同时点（4、6、8周）观察气道结构及气道反应性的变化，探讨气道重建对气道反应性的影响。

AIM : To establish a guinea pig asthma model and to evaluate the effect of airway remodeling on airway responsiveness .

目的：观察中药蓝玉簪颗粒对慢性哮喘小鼠气道重建的抑制作用并探讨其机制。

AIM : To evaluate the protective effect of Lanyuzan granules on airway remodelling in a murine model of chronic asthma and its mechanism .

慢性哮喘模型与急性哮喘模型比较仅平滑肌增生和管壁纤维化计分有差异（P<0.05）。

Between chonic asthmatic group and acute asthmatic group , only grade of hypertrophy of airway smooth muscle and airway fibrosis is different ( P < 0.05 ) .

方法复制慢性哮喘动物模型，分为低压低氧（低压舱）治疗组、常压低氧吸入治疗组及不治组，并设正常对照组，电镜观察海马超微结构变化。

Methods The replicated animal model of chronic asthma was divided into hypoxia ( low pressure chamber ) treatment group , normal pressure hypoxia inhaling treatment group , non treatment group and control group . The ultrastructural changes of hippocampus were observed with electron microscope .

目的：探讨黄芪精口服液对老年慢性支气管哮喘患者SOD的影响和临床意义。

Objective To investigate the therapertic effect of oral liquid preparation of astragalus membranaceous in aged patients with chronic bronchial asthma with special reference on the serum SOD levels .

方法：应用放射免疫分析测定了42例老年慢性支气管哮喘患者血清SOD含量，并以35名正常健康人作比较。

Methods Serum SOD levels were measured with RIA in 42 aged patients with chronic bronchial asthma both before and after a course of treatment with oral liquid preparation of astragalus membranaceous ( 10ml b.i.d for 3 months ) as well as in 35 controls .

结果：老年慢性支气管哮喘患者血清TNF-α和IL-6水平非常显著地高于正常人组（P<0.01），经治疗2周后则与正常人比较无显著性差异（P>0.05）。

Results Serum TNF - α and IL-6 levels were significantly higher in the patients than those in controls ( P < 0.01 ) . After treatment two weeks there were no significant differences between the levels in these two groups ( P > 0.05 ) .

儿童慢性轻度哮喘治疗的临床研究

Clinical study on treatment in children with mild chronic asthma

胚胎肾上腺皮质组织移植治疗慢性支气管哮喘154例

Transplantation with embryonic adrenal cortex for the treatment of chronic bronchial asthma : a report of 154 cases

方法：49例慢性支气管哮喘急性发作期的住院病人随机分成两组：大剂量肝素超声雾化吸入组28例；

Methods : Forty nine patients with acute episode of bronchial asthma were randomly divided into two groups .

目的：探讨甘草对慢性小鼠哮喘模型气道炎症及外周血Th1/Th2失衡的影响。

AIM : To explore the effect of liquorice on airway inflammation and Th_1 / Th_2 imbalance in chronic asthma .

目的：验证喘可治注射液治疗成人急慢性支气管哮喘的临床疗效。

Objective : To prove the clinical therapeutic effect of acute and chronic bronchial asthma with Chuankezhi ( CKZ ) Injection .

结论：黄芪精口服液对老年慢性支气管哮喘有较好的防治作用，有一定的临床实用价值。

Conclusion Oral liquid preparation of astragalus membranaceous was therapeutically useful for chronic bronchial asthma in aged patients with correction of the serum SOD levels .

方法将120例3～8岁慢性轻度哮喘患儿随机均分为治疗组1、2和对照组。

Methods 120 children aged 3 ~ 8 years with chronic mild asthma were randomly divided into two groups , 40 for each in treated group and control group .

目的：利用高分辨率CT（HRCT）探讨慢性稳定期哮喘患者的气道重塑。

Objective : To explore the airway remodeling in patients with chronic stable asthma by high-resolution CT ( HRCT ) .

成人相对低的ADC值可能提示会发展成呼吸道疾病，比如慢性支气管炎和哮喘。

Relatively low ADC values in adults are a possible indication of a developing respiratory problem , such as chronic bronchitis or asthma .

结果：慢性稳定期哮喘患者肺密度的平均CT值为-904（-826～-958）HU，而慢性支气管炎患者的肺密度平均CT值为-943（-908～-992）HU，比哮喘患者低（P<0.05）。

Results : The mean value of the CT Lung density in the patients with asthma was higher than that in the patients with chronic bronchitis ( - 904 HU and - 943 HU , P < 0.05 ) .

结论：部分慢性稳定期哮喘患者肺密度的平均CT值较正常人低，不受气体陷闭的影响，且与慢性支气管炎患者的肺气肿相似，从形态学上间接反映了哮喘患者的气道重塑。

Conclusion : Some patients with chronic asthma develop a reduction in computed tomography lung density which is not affected by air trapping , similar to that in patients with chronic bronchitis , which morphologically reflect the airway remodeling in patients with asthma indirectly .

气道慢性炎症是哮喘和慢性阻塞性肺疾病的本质特点。

Chronic inflammation of airway is the keystone of asthma and COPD .