感觉过敏

腹泻型肠易激综合征（IBS-D）是我国IBS最常见的类型，其发病机制复杂，包括内脏感觉过敏、肠道动力增强、脑肠作用异常、神经-内分泌-免疫网络异常等。

Diarrhea-predominant IBS is the major type of IBS in China , the pathogenetic mechanisms of IBS-D are complicated , including visceral hyperesthesia , enhanced colonic motility , brain-gut dysfunction , abnormal neuro-immuno-endocrine network and so on .

非糜烂性胃食管反流病患者食管内脏感觉过敏与P物质表达的关系

Relationship between esophageal visceral hyperesthesia and expression of substance P in LES of patients with non-erosive gastro-oesophageal reflux disease

中缝背核c-fos、5-HT在IBS内脏感觉过敏机制中的作用

Role of C-fos and 5-HT of Dorsal Raphe Nucleus in the Pathogenesis of Visceral Hypersensitivity in Irritable Bowel Syndrome

目的探讨胃黏膜中降钙素基因相关肽（CGRP）在胃机械感觉过敏形成机制中的作用。

Objective To investigate the role of calcitonin gene-related peptide ( CGRP ) of gastric mucosa in the mechanism of gastric hypersensitivity .

目的：探讨FD患者是否存在胃机械感觉过敏，同时了解胃顺应性变化。

Aims : To appraise whether it exists mechanical gastric hyperaesthesia in FD patients and to learn concomitantly any change in gastric compliance .

结肠粘膜低度炎症诱发小鼠结肠PAR-2活化和内脏感觉过敏

Low Grade Mucosal Inflammation Activated the Colonic PAR-2 and Visceral Hypersensitivity in Mice

结论：部分FD患者中存在着胃机械感觉过敏，近端胃顺应性正常。

Conclusions : Mechanical gastric hyperaesthesia is present in a portion of FD patients , whereas the proximal gastric compliance is normal in FD patients .

目的研究非糜烂性胃食管反流病（NERD）患者食管内脏感觉过敏与食管下端括约肌（LES）黏膜中P物质（SP）免疫反应阳性产物表达之间的关系。

Objective To investigate the correlations between esophageal visceral hyperesthesia and the expression of substance P ( SP ) immunoreactive fibers in the lower esophageal sphincter ( LES ) .

结论FD病人感知过敏组胃粘膜CGRP及SP阳性纤维中合成和释放CGRP、SP是增加的，可能与胃机械感觉过敏有关。

Conclusion Patients with FD have gastric hypersensitivity to mechanical stimulation . The synthesis and release of CGRP and SP were increased in FD-GH , which was related to the gastric hypersensitivity .

背景：功能性消化不良（FD）是临床上常见的症候群，其发病机制目前尚未完全阐明，现逐步认识到胃感觉过敏可能在FD的发病中起着重要作用。

Background : Functional dyspepsia ( FD ) is very common in clinical practice , its pathogenesis has not yet been completely clarified , of which gastric hypersensitivity may play an important role .

背景：食管内脏高敏感性是非糜烂性反流病（NERD）最重要的病理生理特征之一，但引起食管内脏感觉过敏的确切机制仍不甚清楚。

Background : Esophageal visceral hypersensitivity plays an important role in the pathogenesis of non-erosive reflux disease ( NERD ), but the mechanisms responsible for esophageal hypersensitivity in NERD are poorly understood .

结论胃感觉过敏可能与近端胃黏膜中5HT合成增加及5HT1A受体表达增高有关。

Conclusion 5-HT may be involved in gastric hypersensitivity through increasing synthesis of 5-HT and 5-HT_ ~ 1A receptor .

肥大细胞在胃感觉过敏患者胃黏膜中的改变

Change of mast cell in gastric mucosa of patients with gastric hypersensitivity

结论丁酸钠溶液反复灌肠可诱导大鼠内脏感觉过敏；

Conclusion Butyrate enema could induced a sustained colonic hypersensitivity in rats .

胃感觉过敏患者胃黏膜5-羟色胺阳性细胞的变化

Changes of 5-Hydroxytryptamine-positive Cells in Gastric Mucosa of Patients with Gastric Hypersensitivity

功能性消化不良胃机械感觉过敏和降钙素基因相关肽的关系

Relationship between gastric hypersensitivity and calcitonin gene-related peptide in patients with functional dyspepsia

替加色罗对内脏感觉过敏大鼠模型的抗伤害性感觉作用

The anti - nociceptive property of tegaserod on rat model of visceral hypersensitivity

5-羟色胺在胃机械感觉过敏中的作用

Role of 5 - hydroxytryptamine in gastric hypersensitivity

快动眼睡眠剥夺对丁酸钠诱导的内脏感觉过敏大鼠模型的调节作用

The effects of rapid eye movement sleep deprivation on visceral hypersensitivity induced by rectal instillation of butyrate in rats

结论：1、肠易激综合征内脏感觉过敏大鼠有血液流变性和血管内皮功能的异常改变，肠易激综合征内脏感觉过敏与血瘀相关。

Conclusion : There are some statistical changes of hemorheological parameters and endothelium function in visceral hypersensitivity rats of IBS .

除非病人感觉过敏，通常在？窝区没有疼痛。

Unless the patient has a very sensitive bowstring sign , no pain is felt in the popliteal fossa region .

结论新生大鼠给予结直肠机械刺激在成年后可导致慢性内脏感觉过敏；

Conclusion With colon mechanical irritation during the periods of postnatal development , the adult rats can develop chronic visceral hypersensitivity .

肠易激综合征内脏感觉过敏与血瘀相关性研究神经病理性痛觉过敏下丘脑弓状核中枢敏感化的机理研究

Study of Blood Stasis on the Rat Model of Visceral Hypersensitivity of Irritable Bowel Syndrome Mechanisms of Central Sensitization of Neuropathic Hyperalgesia in the Hypothalamic Arcuate Nucleus

结果：功能性消化不良患者胃感觉过敏和动力障碍与胃黏膜肥大细胞数量增多及脱颗粒有关。

Result Gastric hypersensitivity and motor disorders existing in functional dyspepsia may be correlated with the increase of the number and of the degranulation of mast cells in gastric mucosa .

结果骨折均一期愈合，4例坐骨神经损伤中，3例下肢顽固性疼痛和感觉过敏者，2例疼痛消失，1例疼痛减轻，感觉均恢复；1例足下垂未恢复；

Results All fractures got primary union . In the 4 cases with sciatic nerve injuries , 3 were lower extremities obstinate pain and hyperalgesia and got pain removal in 2 and relief in 1 , and 1 was foot-drop and got no improvement .

近年来研究表明，脊髓后角神经元内蛋白激酶C（PKC）的激活和位移与痛感觉及痛过敏的形成有关。

Many studies in recent years indicated that the activation and translocation of protein kinase C ( PKC ) of neurons in the dorsal horn of spinal cord was related with hype .

呼吸道P物质感觉神经与豚鼠过敏性气管条收缩

Substance P sensory nerve fibres and contractions of sensitized guinea pig tracheal strips

所有受试者主观感觉良好，无过敏等副作用。

In the clinical trial , every body felt well and no side-effect was observed .

临床上的许多疾病的过程往往伴随着人体感觉功能的变化，引起感觉迟钝或过敏。

Lots of diseases come with dysfunctions to the sensory system , causing hypoesthesia or hyperesthesia .

电子恒压器测定所有受试者胃机械感觉阈值，根据阈值不同，将FD患者分为胃机械感觉正常组和胃机械感觉过敏组。

A barostat was used to detect perception thresholds in all the subjects . According to the thresholds , the FD patients were divided into gastric hypersensitivity group and normal sensitivity group .