心肌肥大

运动性心肌肥大与机体肾素-血管紧张素系统（RAS）有着密切的关系。

There is a close relation between exercise-induced myocardial hypertrophy and renin-angiotensin system ( RAS ) .

目的：观察一氧化氮（NO）和血管紧张素Ⅱ（AngⅡ）在压力超负荷心肌肥大反应过程中的作用。

To investigate the effects of nitric oxide ( NO ) and angiotensin ⅱ on myocardial hypertrophy caused by overloaded pressure .

结果显示，耐力训练24天后，心系数增加十分显著（P＜0.01），表明已出现心肌肥大。

The results showed that the cardiac coefficent increased remarkably ( P < 0.01 ) after 24 days training , which suggests myocardium hypertrophy happened .

压力超负荷致心肌肥大时调控bFGF表达变化的机制研究

Investigation of mechanism of myocardial bFGF expression during acute pressure overload

心肌肥大大鼠心肌细胞凋亡与Bcl-2、Bax蛋白表达的变化

Cardiomyocyte apoptosis and the expression of Bcl-2 and Bax protein in rats with myocardial hypertrophy

目的：应用cDNAchip（cDNA芯片或微矩阵基因芯片）技术筛选运动性心肌肥大相关基因。

Objective To screen the differentially expressed genes of exercise-induced cardiac hypertrophy in mice cardiac muscle tissue using cDNA microarray .

一氧化氮抑制AngⅡ介导的心肌肥大反应的信号机制

Molecular mechanism of nitric oxide in preventing cardiomyocytes from hypertrophic response induced by angiotensin ⅱ

目的：在异丙肾上腺素（Iso）导致的心肌肥大纤维化模型上观察了心肌线粒体钙转运功能的变化。

Objective : 45Ca2 + transport of cardiac mitochondria was investigated on the model of isoproterenol induced cardiac hypertrophy .

NADPH氧化酶-4对大鼠高血压性心肌肥大的影响

Effect of NADPH oxidase-4 on hypertension induced myocardial hypertrophy in rat

目的：研究内皮素-1（ET-1）诱导心肌肥大的机制及对抗的药物。

AIM : To investigate the mechanism of cardiac myocyte hypertrophy induced by endothelin-1 ( ET-1 ) .

目的观察异丙基肾上腺素（isoproterenol，Iso）导致的心肌肥大大鼠的心肌细胞牛磺酸（taurine，TAU）跨膜转运功能的改变。

AIM To observe myocardial taurine transport in the isoproterenol ( Iso ) induced rats .

丹参酮IIA磺酸钠对血管紧张素II诱导的心肌肥大及p-ERK表达的影响

Effects of sodium tanshinone IIA sulfonate on Ang II-induced cardiomyocyte hypertrophy and p-ERK expression

多层螺旋CT在先天性主动脉缩窄和主动脉弓离断诊断中的应用左肾动脉缩窄诱导心肌肥大大鼠心肌蛋白差异表达研究

Diagnostic Value of Multi Slice Spiral Computed Tomography in the Evaluation of Coarctation of Aorta and Interruption Aortic Arch PROTEOMIC ANALYSIS OF MYOCARDIAL HYPERTROPHY INDUCED BY LEFT KIDNEY ARTERY COARCTATION IN RATS

术后8周测定动脉血压、心肌肥大指数及心肌组织MAPK的表达。

The blood pressure , cardiac hypertrophy parameter and expression of MAPK in myocardium were measured at eighth week .

结论：AngⅡ具有诱导心肌肥大的作用且呈量效关系，此作用通过AngⅡ受体介导；AngⅡ的这种肥大作用可能部分依赖于PTX敏感的G蛋白，并由PKC介导；

Conclusions : The mechanism of Ang II-induced cardiomyocyte hypertrophic was linked with Ang II receptor and PTX sensitive G protein ;

MAPK及MKP-1在肾性高血压大鼠心肌肥大过程中的变化

The Change of MKP-1 and MAPK in Myocardium of Renovascular Hypertensive Rats

近年来，已有越来越多的证据表明：心脏局部肾素-血管紧张素（RAS），在高血压病心肌肥大的发生、发展中可能具有重要的病理意义。

More recently , rennin-angiotensin system ( RAS ) activation has been understood to be a major inducer of cardiac tissue hypertrophy .

在运动性心肌肥大过程中，IGF-1作为机械刺激和基因表达的连接物发挥重要作用。

IGF-1 play an important role as a juncture betweenmechanism stimulation and expression in the process of exercise-induced cardiac hypertrophy .

AngⅡ参与诱发压力超负荷高血压和心肌肥大反应的发生。

And that Ang ⅱ had participated in the reactive process of inducing the rats ' pressure overload hypertension and cardiac hypertrophy .

目的：探讨转化生长因子β1（TGFβ1）在人体心肌肥大组织中的表达变化及其意义。

Objective : To investigate change and significance of transform growth factor - β _1 ( TGF - β _1 ) gene expression in patients with heart hypertrophy .

容量超负荷心肌肥大时局部心肌AngⅡ，bFGF的变化及ATI受体拮抗剂对其影响的实验研究

Effect of myocardial bFGF , Ang ⅱ and ATI receptor antagonist on myocardial hypertrophy in the early stage of acute volum overload

目的：观察钙调神经磷酸酶（calcineurin，CaN）依赖的信号通路在大鼠心肌肥大中的作用。

Objective : To determine the role of calcineurin dependent signal pathway in cardiac hypertrophy of rats .

采用RTPCR法检测心肌肥大特征性基因心钠素（ANP）和脑钠素（BNP）mRNA的表达，并以3H亮氨酸掺入测定心肌细胞蛋白合成速率。

ANP and BNP mRNA expression was evaluated by RT-PCR , and the rate of protein synthesis in CM by 3 H - leucine incorporation in cardiac myocytes .

结论糖尿病大鼠的心肌肥大与c-myc原癌基因的过多表达有关，胰岛素预处理可抑制c-myc原癌基因的表达。

Conclusions The cardiac hypertrophy of the diabetic rats are related to overexpression of c-myc proto-oncogene , and insulin pretreatment can decrease c-myc mRNA expression .

利用体外细胞培养技术，观察了丹参素对血管紧张素Ⅱ（AngⅡ）致心肌肥大的影响。

An in vitro cell culture technique was used to study the effects of danshensu on the myocardial hypertrophy induced by angiotensin ⅱ ( Ang ⅱ) .

所以认为CT-1介导的心肌肥大更倾向于容量超负荷的改变，而慢性容量超负荷最终将导致心肌不可逆性的功能丧失。

Chronic volume overload hypertrophy can result in an irreversible loss of cardiac function .

25、50、75mg/kgPNS可显著降低心肌肥大大鼠左心室指数。

PNS ( 25 , 50 , and 75 mg / kg ) could markedly reduce the left ventricular index of myocardial hypertrophy rats .

目的：探讨醛固酮（Ald）诱导心肌肥大的大鼠模型中，血浆神经肽Y（NPY）含量的变化。方法：健康雄性Wis-tar大鼠21只，随机分为3组：1正常对照组；

AIM : To investigate the chenges of plasma neuropeptide Y ( NPY ) level in aldosterone ( Ald ) - induced cardiac hypertrophic rats .

方法：采用升主动脉缩窄法制备左心室压力超负荷心肌肥大（LVH）和充血性心衰（CHF）大鼠病理模型；

METHODS : Left ventricle pressure overload hypertrophy ( LVH ) and congestive heart failure ( CHF ) models were created in rats by ascending aortic banding .

因为Akt的过度激活可导致心肌肥大和心力衰竭，本实验结果可能提示，cGMP可防止心衰的发生。

Because an excessive activation of Akt may lead to cardiac hypertrophy and heart failure , our finding suggests that cGMP may prevent hypertrophy and heart failure .