微管蛋白

CLIP-170定位于气道上皮细胞胞质内，与微管蛋白有共定位关系。

CLIP-170 was located in the cytoplasm of airway epithelia and co-located with β - tubulin .

本研究利用猪脑中分离纯化的微管蛋白聚合和解聚反应，分析了具有争议的非整倍体诱发剂2（4′噻唑）苯丙咪唑（thiabendazole，TBZ）对微管蛋白聚合状态的影响。

Tubulin isolated from porcine brain was employed in the experiment to study the mechanism of aneuploidy induced by thiabendazole ( TBZ ) by analyzing the polymerization of tubulin .

结果雌性激素可显著地增加鼠脑微管蛋白含量（P＜0.005）。

Results Estrogens increased brain tubulin amount ( P < 0 05 ) and lengthened the life span ( P < 0 005 ) .

β-微管蛋白Ⅲ，Bcl-2在非小细胞肺癌中的表达及临床意义

Expression of β - tubulin III and Bcl-2 and the clinical significance in non-small cell lung cancer

它能够在秋水仙碱位点抑制微管蛋白的聚合，诱导癌症细胞的凋亡，目前已进入II期临床。

It inhibits microtubule polymerization by binding to the colchicine binding site on β - tubulin and induces the cancer cell apoptosis .

人β-微管蛋白2C蛋白的原核表达与纯化

Prokaryotic expression and purification of human beta tubulin 2C protein

方法我们从兔脑组织中纯化出微管蛋白，并纯化出原核表达的TAU和PRP蛋白。

Methods Tubulin protein was extracted from rabbit brain .

同时血小板胞质内游离的β-微管蛋白、tau蛋白增多。

The level of free β - tubulin and tau protein increased in platelets .

它周期性地表达在细胞周期的G2/M期，并通过与细胞有丝分裂纺锤体微管蛋白结合，抑制半胱氨酸蛋白酶3、7（caspase3、7）的活性，从而抑制细胞凋亡。

It regularly expresses in G2 / M phase and suppresses the activity of caspase 3 and caspase ? by binding to the micro-tube protein of the cell mitotic spindle .

Tau蛋白具有促进微管蛋白聚合成微管、稳定微管结构和维持神经功能的作用。

Its physiological function is promoting tubulin polymerization into microtubules , stabilizing micro-tubular structure and maintaining nerve function .

加抗肌动蛋白、vimentin和微管蛋白抗体进行免疫组织化学及westernblot分析。

Antibodies of anti-cytoskeleton such as anti-tubulin , actin and vimentin were applied for the immunohistochemical staining and Western blot analysis in HLECs and rat lens epithelia .

JWA蛋白与α-微管蛋白结合和对微管稳定性的调节

JWA protein binds to α - tubulin and regulates microtubule stability

目的研究半边旗提取物5F对微管蛋白聚合的影响。

Aim To study the effect of 5F on tubulin polymerization .

设计1对正、反向引物btubf/btubr，对家蚕微孢子虫（镇江株）基因组DNA的β-微管蛋白（beta-tubulin）基因进行扩增，得到部分片段。

A beta-tubulin DNA fragment of the Zhenjiang strain of Nosema bombycis was obtained by primers btubf / btubr .

JWA与α-微管蛋白结合的结构和功能关系研究

The Relationships between Structure and Function of JWA Binds to α - tubulin

Survivin的表达具有细胞周期依赖性，在细胞周期的G2／M期表达，在有丝分裂过程中与纺锤体的微管蛋白相连。

Survivin is expressed in the G2-M phase of the cell cycle in a cell cycle-regulated manner and associates with microtubules of the mitotic spindle .

用PCR与测序技术相结合的方法，对不同品质棉花品种（系）的α-微管蛋白基因进行序列分析；

Sequence of α - tubulin , the gene which is correlative with fiber development , was analyzed with the means of linking PCR and sequencing from cotton varieties ( lines ) with different quality .

紫杉烷C-2位改造的化合物的合成、抗癌活性及其与P-糖蛋白和β-微管蛋白的相互作用

Synthesis , Biological Activity and Interactions with P-glycoprotein and β - tubulin of C-2 Modified Taxanes

结果发现：THH能显著抑制体外微管蛋白的聚合，该抑制效应呈明显的剂量&效应关系。

The experiment found that THH can inhibit the polymerization significantly and showed a dose-effect relationship .

3鼠抗γ微管蛋白单克隆抗体、FITC偶联山羊抗鼠IgG及相关试剂

3 Monoclonal anti - y - tubulin antibody derived from a mouse with GTU - 88 hybridoma ; FITC conjugated goat anti - mouse IgG and other relevant reagents

DNA序列对照表明中国的3个敏感菌株和3个抗药菌株的α-微管蛋白基因核苷酸序列同源性没有差异，多菌灵抗药性与α-微管蛋白无关。

The DNA sequence comparison showed that there was no difference in the nucleotide sequence of α - tubulin gene amongst 3 sensitive and 3 resistant strains from China . This result demonstrates that there is no relationship between MBC-resistance and α - tubulin gene .

结果IEC在烧伤血清作用早期，骨架蛋白的表达即明显降低，微丝、微管蛋白阳性信号减弱，细胞粘弹性下降。

Results During the early stage of burn serum stimulation , the skeleton protein expression in IEC decreased obviously with weakened positive signals of microfilaments and microtubules and with decreased cellular elasticity .

Zajoene抗肿瘤机制与诱导细胞凋亡和干扰微管蛋白聚合相关。

All these findings suggest that antitumor mechanism of Z-ajoene is related to its actions of apoptosis induction and interruption of tubulin assembly .

结论5F能抑制体外微管蛋白聚合，从而可能是影响细胞的细胞周期及诱导凋亡途径之一。

Conclusion 5F inhibits tubulin polymerization and depolymerization , and leads to cell cycle arrested , and possibly induces apoptosis .

目的：观察血管性痴呆（Vasculardementia，VD）患者皮肤基底细胞α-微管蛋白的变化，从细胞的超微结构变化探讨其皮肤基底细胞α-微管蛋白与VD的关系。

AIM : To observe the changes of α tubulin in skin from vascular dementia ( VD ) patients and investigate the relationship of α tubulin and vascular dementia from the changes of cellular ultrastructure .

目的通过观察中枢神经系统（CNS）中α-微管蛋白（α-Tub）及β-微管蛋白（β-Tub）的表达，探讨膳食锌调节CNS微管聚合作用的可能机制。

Objective : To determine the effects of zinc deficiency on microtubules polymerization and the expression of α tubulin and β tubulin subunits in the central nervous system ( CNS ) of mice .

通过GSTPullDown实验研究TAU与微管蛋白的相互作用，PRP对TAU与微管蛋白相互作用的影响。

Microtubules formed by tubulin were observed by electron microscope ( EM ) . GST pull down test was used to judge PrP effect on the interaction of tau and tubulin protein .

另外MPD对微管蛋白聚合的抑制作用也有可能是MPD将肝癌细胞阻滞在G2/M期的因素之一。

On the other hand , MPD could inhibit the polymerization of microtubule protein that may conduce to G2 / M phase arrest .

结果5F能抑制反应体系吸光值升高，提示它对微管蛋白聚合具有抑制作用并能抑制其解聚。

Results 5F decreased the Absorption values of the reaction system . and markedly inhibited not only tubulin polymerization but also tubulin depolymerization .

通过Alingment分析，表明我们得到的微管蛋白基因具有相应的特征性结构。

Alignment analyses suggest tubulin genes from plant hoppers contain corresponding characteristic sequences .