异博定

40mg/kg异博定只明显地抑制DTH反应和降低小鼠胸、脾重量。

40 mg / kg verapamil only inhibits DTH reaction and reduces the weight of thymus .

目的：建立视网膜缺血再灌注损伤模型，用视网膜电（流）图（ERG）观察异博定对视网膜ERG的影响。

Objective To establish the model of retina ischemia-reperfusion injury , observe the effect of verapamil on retina ERG .

MTT法测定异博定逆转胃癌与结肠癌细胞多药物抗性的研究

Reversal of multidrug resistance in gastric and colon cancer cells by verapamil using MTT assay

保存液中加入钙拮抗剂异博定（VP）后，上述现象可得以显著抑制。

But these could be inhibited in those storing in the HCA solution with VP pre-supplement .

钙拮抗剂异博定增强博来霉素A5对人肝癌BEL-7402细胞的毒性作用

Potentiation of bleomycin a_5 cytotoxicity to human hepatoma BEL-7402 cells by calcium antagonist verapamil

用MTT法测定离体前列腺上皮细胞和成纤维细胞的增殖MTT法测定异博定逆转胃癌与结肠癌细胞多药物抗性的研究

A study of tetrazolium dye based assay for cell proliferation of epithelial and fibroblast cells from prostates . REVERSAL OF MULTIDRUG RESISTANCE IN GASTRIC AND COLON CANCER CELLS BY VERAPAMIL USING MTT ASSAY

目的：观察钙调素拮抗剂三氟拉嗪（TFP）及钙通道阻滞剂异博定（VP）对缺钙-复钙损伤心肌的保护作用。

AIM : To observe the protective effect of calmodulin antagonist trifluoperazine ( TFP ) and slow calcium channel antagonist verapamil ( VP ) upon calcium overload injury .

作者认为，异博定的降热作用很可能是通过抑制下丘脑PGE的合成而减弱其发热效应的，而cAMP可能不参与其降热机制。

It was suggested that most likely this anti-pyretic action was due to the effect on biosynthesis of PGE in hypothalamus , while , cAMP might not be involved in the mechanism of this antipyretic action .

小鼠脑室内注射少量CaCl2及腹腔注射钙通道阻断剂异博定（verapamil）均可抑制电针的镇痛效应。

The analgesic function produced by acupuncture was inhibited by injecting small amount of CaCl 2 into the mice brain . These changes were all resisted by verapamil , a calcium channel inhibitor .

Neferine+ADM组和异博定+ADM组比较，P-gp的阳性表达率和平均光密度无显著差异（P>0.05）。

There was no difference with P-gp positive rate and it 's OD on acute leukemic cells between neferine adding ADM group and verapamil adding ADM group ( P > 0.05 ) .

应用肿瘤细胞增殖抑制、克隆形成、流式细胞术，研究了钙拮抗剂异博定（Ver）与博来霉素A5（BLMA5）对人肝癌BEL-7402细胞的影响。

Effect of verapamil in combined with bleomycin A_5 ( BLM A_5 ) on the human hepatoma BEL-7402 cells is studied using growth-inhibition of tumor cells , colony formation , flow cytometry methods .

对照组应用异博定注射液，总剂量5-10mg，用法同治疗组。

Verapamil injection was applied in control group , its total amount was 5-10 mg .

与ADM组比较，neferine+ADM组和异博定+ADM组的P-gp阳性表达率及P-gp平均光密度显著下降（P<0.01）。

The P-gp positive rate and it 's optical density ( OD ) on acute leukemic cells of neferine adding ADM group and verapamil adding ADM group were significantly lower than those of ADM group ( P < 0.05 ) .

按1979年兰州会议标准，使用异博定治疗45例高血压病，每天总剂量240mg，疗程定为8周。

Based upon the criteria established on the Lanzhou Meeting in 1979 , forty five cases of hyperten - sion were treated with verapamil . The daily dose was 240 mg and the course of treatment was 8 weeks .

异博定对乳腺癌细胞多药耐药性逆转作用的研究

Reversal Effect of Multidrug Resistance in Human Breast Cancer Cells by Verapamil

和异博定确保它不复发就行了。

And verapamil so it doesn 't recur .

目的探讨缓释异博定对原发性高血压的临床疗效。

Objective To discuss the clinical effect of delayed release verapamil on treatment of primary hypertension .

结论黄芪、异博定对庆大霉素肾毒性有保护作用。

Conclusion Huangqi and isoptin may play a role in the protection of nephrotoxicity induced by gentamicin .

川芎嗪和异博定联合逆转HL60/HT细胞的多药耐药

Reversal of multidrug resistance of HL60 / HT leukemia cell line by combination of tetramethylpyrazine and verapamil

异博定和氯化钙对电针镇痛效果及小鼠脑细胞游离钙镁浓度的影响

Effects of calcium chloride and verapamil on analgesia of electroacupuncture and cytoplasmic free calcium and magnesium concentrations of mice brain

应用环糊精-毛细管区带电泳体系对手性药物盐酸美西律和盐酸异博定的对映体分离进行了研究。

The enantiomeric separation of chiral drugs mexiletine and verapamil was investigated using cyclodextrins added buffers at acidic conditions in capillary zone electrophoresis .

本文报告离子通道阻断剂河豚毒素、四乙胺、异博定、硝普钠对豚鼠离体小肠电活动与收缩活动的影响。

The paper deals with the effects of some blockers of ion channel on electrical activity and contractile activity of the guinea-pig small intestine in vitro .

结果表明，异博定能增加肌酐清除率，降低血尿素氮和滤过钠排泄分数，可以保护肾小球、肾小管的细胞结构，有防治急性肾功能衰竭的作用。

The results showed that verapamil increased creatinine clearance rate ( Ccr ), reduced blood urine nitrogen ( BUN ) and filtration excretion of sodium ( FENa ), and protected the kidneys from acute renal failure in rabbits .

相继发现了异博定、环孢霉素等多种逆转药物，但因具有心血管毒性、免疫抑制、肾毒性等严重毒性和不良反应而使其临床应用受到限制。

Many kinds of agents , such as verapamil and cyclosporine , have been found . But they were limited used in clinic because of their side effects including toxicity in cardiovascular system , immunity inhibition , renal toxicity and others .

方法利用柔红霉素自发荧光特点，以流式细胞仪测定川芎嗪或和异博定与柔红霉素伍用体外孵育后6例脐带血细胞内柔红霉素浓度。

Method According to the fluorescent property of DNM , flow cytometry was used to detect the level of DNM in the monocytes of 6 cases ' DNM containing umbilical cord blood after being incubated with TMP and / or VP in vitro .