壬二酸

壬二酸对人黑素细胞和鼠黑素瘤B（16）细胞黑素合成功能的影响

Effects of Azelaic acid on melanin synthesis of human melanocyte and mouse B16 melanoma cells in vitro

对照组36例，采用口服维生素E、维生素C，20%壬二酸霜外涂治疗。

Vit E and Vit C were orally taken and 20 % Azelaic Acid cream was given for external use to 36 patients in control group .

以恶性黑色素瘤鼠B（16）细胞株和人表皮黑素（MC）细胞作为研究对象，检测壬二酸对B（16）细胞和MC细胞黑素含量和酪氨酸酶（tyrosinase）的影响；

The influence of azelaic acid on melanin synthesis and tyrosinase activity of human melanocytes and murine B_ ( 16 ) melanoma cells were studied ;

测定壬二酸对人表皮黑素细胞和鼠黑色素瘤B16细胞酪氨酸酶活性及黑素含量变化观察壬二酸的脱色素作用。

The influence of azelaic acid on melanin synthesis and tyrosinase activity of human melanocytes and murine B16 melanoma cells were studied .

壬二酸抑制人表皮黑素细胞和鼠黑素瘤B16细胞的酪氨酸酶活性，细胞黑素合成减少，而且具有浓度依赖性。

The melanin synthesis and tyrosinase activity of human epidermal cells and murine B16 melanoma cells were inhibited by Azelaic acid in a dose-dependent manner .

目的建立体外培养的正常人表皮黑素细胞系，检测壬二酸对人表皮黑素细胞和鼠黑素瘤B16细胞黑素合成的影响。

Objective To establish human normal melanocytes cell line in vitro and observe the effects of Azelaic acid on the pigment production of the epidermal melanocytes and B16 cells .

结果表明：当臭氧化温度为25～30℃，氧化裂解温度为90～950℃，催化剂的质量为亚油酸质量的0.1%，反应时间2.5h时，壬二酸的收率最高。

The results showed that the yield of azelaic acid was 46 % when the ozonolysis temperature was from 25 ℃ to 30 ℃, the amount of catalyst was 0.1 percent of linoleic acid , the oxidation temperature was between 90 ℃ and 95 ℃, the oxidation time was 2.5 h.

相转移催化氧化法合成壬二酸的研究

Study on the synthesis of azelaic acid by phase transfer catalytic oxidation

壬二酸研究的进展

Study on the development of the application of azelaic acid

壬二酸联合氧化法的合成与反应机理初探

Study on synthesis and reaction mechanism of azelaic acid by united oxidation

混合溶剂下油酸臭氧化催化氧化裂解合成壬二酸的工艺研究

Production of azelaic acid by the compound solvent-ozonization-catalytic oxidation process from oleic acid

成份：壬二酸、透明质酸、金缕梅提取液、氨基酸保湿剂。

Compositions : hyaluronic acid , witch hazel extract and amino acid moisturizer .

壬二酸衍生物凝胶治疗黄褐斑的研究

Study of K-ADG Gel in the Treatment of Chloasma

壬二酸和维A酸治疗面部烧伤后色素沉着的疗效观察

Effects of azelaic acid and tretinoin cream in the treatment of facial post-burn hyperpigmentation

壬二酸合成工艺研究

Study on synthesis of azelaic acid

研究了以油酸甲酯为原料，乙酸和正己烷的混合物做溶剂，臭氧氧化法制备壬二酸单甲酯的方法。

Preparation of azelaic acid monomethyl ester by ozonolysis reaction from oleic acid methyl ester was studied .

壬二酸，用于治疗痤疮的洗液，可以降低变色和炎症（由于酒渣鼻）。

Azelaic acid , a prescription lotion used for acne , can calm discoloration and inflammation due to rosacea as well .

确定了9种化合物的结构，其中豆甾醇、β-谷甾醇、壬二酸等为首次在本属真菌中分离得到。

Nine compounds structure were identified , stigmasterol ,β - sterol , azelaic acid were also obtained from this genus the first time .

获得含有氢醌，漂白剂，褪色点的霜剂；或尝试壬二酸，局部抗炎，抗菌。

Get a prescription cream that contains hydroquinone , a bleaching agent , to fade spots ; or try azelaic acid , a topical anti-inflammatory and antibacterial .

高分子脂肪酸最常用的是12一羟基硬脂酸，低分子酸最常用的是壬二酸、癸二酸、硼酸和水杨酸等。

Fatty acids most commonly used polymer is12 hydroxy stearic acid , low molecular weight acid is the most commonly used azelaic acid , sebacic acid , boric acid and salicylic acid .

本文综述了壬二酸的性质，用途及合成方法，介绍了国内外采用臭氧氧化法合成壬二酸的研究进展。

Properties , synthesis application and of azelaic acid are reviewed , and the paper also reviews on recent advances of synthesis by ozonation from oleic acid were introduced at home and abroad .

以棉油酸为原料、85%醋酸水溶液为溶剂，经臭氧化、氧化分解、沸水萃取、活性炭吸附脱色等过程制备壬二酸的最佳反应条件为：m（棉油酸）：m（85%醋酸）

On the condition of using fatty acids of cottonseed oil as raw material , 85 % acetic acid as solvent , this paper prepared azelaic acid and pelargonic acid by ozonolysis , oxidation decomposition , extracted by boiling water , active carbon absorpting etc.