基因开关

珠蛋白基因开关的组蛋白密码以及转基因鼠中外源基因定位的研究

Deciphering the Histone Code of Globin Gene Switching and Identification of Transgene 's Integration Site

这些因子的确定对于揭示珠蛋白基因开关机制具有决定性意义，本课题的目的就是希望能向此目标迈进。

As the validation of these factors is of significance for disclosing mechanisms of globin gene switching , we hope that our work could contribute to this target .

第二部分，在定量试验数据最为丰富的lambda基因开关系统中，我们试图引入最精细的理论模型解决一些前人不能解释的试验现象。

In the second part , based on the tremendous quantitative data for lambda genetic switch , I try to introduce more quantitative model to resolve the paradox of previous models .

此外，我们还以基因开关体系为研究对象，考察了非马尔科夫效应对基因网络稳定性的影响。

We also study the effect of non-Markovian behavior on the stability of a genetic toggle switch .

结果表明，非马尔科夫效应不仅可以显著改变基因开关的稳定性，而且会对内涨落作用下稳态之间转变过程的具体动力学性质产生不可忽略的作用。

The results indicate that the non-Markovian behavior could not only affect the stability of the bistable switch , but also the dynamics of the transition process .

气孔运动的分子调控离不开高效的基因开关系统，保卫细胞特异性表达的启动子近几年倍受关注。

The genetic regulation of stomatal movement mainly depends on an efficient control system of gene expression , and guard cell-specific promoter is becoming one of the best choices .

研究者在一月份的细胞杂志中报道说，他们发现了控制一种类型肌肉结构的基因开关，而对这种肌肉类型学者们目前为止还不甚了解。

Researchers report in the January issue of the journal Cell Metabolism , published by Cell Press , the discovery of a genetic " switch " that drives the formation of a poorly understood type of muscle .

在生物体系中，双稳态是广泛存在的，从lambda噬菌体基因调控开关到大肠杆菌的菌毛的有无；从乳糖代谢过程中的All-to-None现象到真核生物的表观遗传现象。

Bistable phenomena are widespread in biological system , such as the genetic switch of lambda phage , phase variation of bacterial pili , All-to-None phenomena in lactose metabolic pathway and epigenetics in eukaryote .

转录因子相当于基因的开关。

Transcription GetWord (" Transcription "); factors switch genes on and off in groups .

观察结果表明：心肌等胞质中氧代谢相关的已有基因的开关蛋白质复合体等参与了人工轻度快速缺氧信息的获得；

Switch protein complexes were involved in obtaining artificial slight speedy hypoxia information in cardiac cytoplasm .

染色体核心组蛋白分子作为各种炎症因子和炎症信号转导的关键性终端蛋白质分子，具有基因转录开关分子的功能，其活性受组蛋白转乙酰酶/脱乙酰酶（HAT/HDAC）的调节。

Core histone around which DNA is wound plays a key role as a terminal protein of inflammatory signal transduction on gene transcription .

在人类个体发育过程中存在ε（胚胎型）→γ（胎儿型）→β（成人型）珠蛋白基因表达开关过程。

During human development , two switches of globin gene expression , ε ( embryonic ) →γ ( fetal ) →β ( adult ) occur .

其实让Endy博士更感兴趣的是调节基因表达的开关控制系统。

In particular , Dr Endy is interested in switches and control systems that regulate other genes .

到目前为止，许多免疫学家都以为免疫系统是在转录水平进行调控的，转录因子是控制基因的总开关。

Up to now , most immunologists have assumed the immune system was governed at the level of transcription factors , the master regulator proteins that control how genes are turned off and on .

虽然对于珠蛋白基因表达调控及开关的研究已取得许多进展，但至今对于调节这些开关的决定性调节因子仍不明确。

Although advance has been made in the study on control of globin gene expression and switching , key factors of globin gene switching is still unknown till now .

通过增加或减少特定诱导物，可精确调节目的基因上游构建的基因开关，实现外源目的基因的准确调控，使外源基因在植物体内适时、适量、有效地表达。

By increasing or removal special inducer , gene switch which is constructed in the upstream region of the target gene is regulated , exogenous gene is controlled exactly and achieve efficient expression of exogenous genes in an exact time , certain level or special time .

现在的研究者通过在所要表达的目的基因上游建立一个有效的基因开关，构建出可准确调控的基因表达系统而实现对基因表达的人工调控，使目的基因定时、定量、定位的表达。

Today , researchers put an effective gene switch to control target gene expression on the upstream .

他们发现KLF14和脂肪中发现的远端基因的表达水平间存在相关性，表明KLF14是这些远端基因的“总开关”。

They found an association between the KLF14 gene and the expression levels of multiple distant genes found in fat tissue , which means it acts as a master switch to control these genes .