土木香

土木香内酯和异土木香内酯与共轭二烯的Diels-Alder反应

Diels-Alder Reaction of Alantolactone and Iso (?) lantolactone with Conjugated Dienes

目的：考证土木香是否可以代替青木香用药。

OBJECTIVE : To study whether Radix Inulae can replace Radix Aristolochiae as medicinal material .

所得土木香内酯和异土木香内酯用归一化法定量，纯度均大于98%。

The purity of alantolactone and isoalantolactone was higher than 98 % by normalization method of HPLC .

因此寻找土木香中新的活性化合物，并进一步研究其同类化合物的结构与活性的关系，对土木香的研究开发具有重要意义。

It is interesting to find new active compounds and establish structure-activity relationship further for the research and development of I. helenium .

结果与结论：土木香和青木香在上述各方面均不相同，二者不应替代。

RESULTS & CONCLUSIONS : Radix Inulae and Radix Aristolochiae were different in every aspect , thus the two can 't be replaced by each other as medicinal material .

方法：用薄层色谱法鉴别黄芪、白芍、当归、土木香，用高效液相色谱法测定芍药苷的含量。

Method : Radix Astragali , Radix Paeoniae Al-ba , Radix Angelicae Sinensis , Radix Inulae in this medicine were identified by TLC , and the content of Paeoniflorin in this medicine was determined by HPLC .

因此，这三种药物是相对安全的，土木香和冠心苏合丸（含土木香）可以代替青木香和冠心苏合丸（含青木香）在临床上继续使用。

Therefore , these three drugs are relatively safe . Radix Inulae and Guanxin Suhe Wan ( with Radix Inulae ) can replace Aristolochia debilis and Guanxin Suhe Wan ( with aristolochia debilis ) to be used in clinical practice .