前突变

脆性X相关震颤/共济失调综合征（fragileX-associatedtremor/ataxiasyndrome，FXTAS）是在脆性X综合征前突变携带者中发现的一种神经退行性疾病。

Fragile X-associated tremor / ataxia syndrome ( FXTAS ) is a neurodegenerative disorder identified among fragile X syndrome premutation carriers .

不过大约有20%的带有脆弱X前突变基因的妇女要发生过早绝经。

But up to20 percent of women with fragile X pre-mutations undergo premature menopause .

脆性X家系中的2例患者均检测出大于200CGG重复拷贝的全突变带。1例女性携带者也显示出两条前突变扩增带。

In the fragile X family , 2 affected individuals were detected more than 200 ( CGG ) repeats full mutation bands and 1 female carrier showed pre-mutation bands .

在113例不明原因的先天性智力低下患儿中，分析有脆性X综合征携带者（FMR-1基因前突变者）7例（2男5女），脆性X综合征患者（FMR-1基因突变者）5例。

Carries ( 2 male and 5 female ) and 5 full mutation patients were examined in 113 cases with congenital mentally retarded children .

包括你在内的家族女性可能有基因前突变；

The women in the family ( you included ) may simply have a pre-mutation ;

Penicillumpatulum4541耐前体突变株的选育

Selection of Precursor-resistant Mutant of Penicillum patulum 4541

乙型肝炎病毒基本核心启动子及前C区突变与基因型的关系

Relationship between hepatitis B virus basic core promoter / precore mutations and viral genotypes

无症状HBV感染者病理与前C区突变关系研究

Study on Chronic Asymptomatic HBV Infection and its Relation to Pre-Core Gene Mutation

提示HBV前C区突变与病情轻重及e系统血清标志有关。

In conclusion , HBV precore mutation is connected with degree of disease and serum mark of e system .

HBV宫内传播和HBV前S/S基因突变的关系的初步分析

A preliminary analysis between the mutation of the HBV preS / S gene and HBV intrauterine infection

234例慢性乙型肝炎患者HBV前C/BCP区突变分析

Mutation of hepatitis B virus precore / basal core promoter in 234 patients with chronic hepatitis B

本研究发现在我国西安地区存在HBV前C区突变株的感染，对进一步研究乙型肝炎发病机理具有重要意义。

This is the first report about the infection of mutants in HBV pre-C region detected in Xi'an area of China and it would play an important role in studying the pathogenesis of hepatitis B.

381例HBV感染者HBVdna前C区基因突变的研究

Study of HBV DNA precore mutation in 381 patients with HBV infection

慢性乙型肝炎患者HBe系统与HBVdna前C区基因突变的分析

Analysis of HBe System and Precore Mutation of HBV DNA in Chronic Hepatitis B

整合型HBV-DNA前C区基因突变与肝细胞癌的相关性

The correlation between gene mutation on precore region of HBV DNA integration and hepatocellular carcinoma

在西安地区HBeAg阴性患者中检出乙型肝炎病毒前C区基因突变株

Detection of pre-C region mutants in hepatitis B virus from HBeAg-negative patients in Xi'an area of China

乙肝病毒S基因亚型、前C区点突变与HBe系统的关系研究

Study on Correlation of HBVs-gene Subtype and HBV Precore Mutation and HBe System

目的研究宫内传播中乙型肝炎病毒前S/S基因的突变，探讨宫内感染乙型肝炎病毒与HBV基因突变的关系。

Objective To investigate the relationship between HBV intrauterine infection and gene mutation by analysis of HBV preS / S gene sequence .

结论后带效应、HBeAg/IC、前C区基因突变是HBVdna阳性血清HBeAg阴性的主要原因；

Conclusion Hook effect of post-zone , formation of HBeAg / IC and gene mutation of Pre C region were the main reasons of negative HBeAg result by ELISA in the specimen with positive HBV DNA .

目的利用艾滋病病毒1型（HIV-1）耐药性基因型检测法，在HIV-1感染者中监测HIV-1耐药性病毒株，掌握广东省HIV-1感染者在利用抗病毒药物治疗前是否存在耐药突变及其流行情况。

Objective To apply HIV-1 genotyping in the surveillance of subjects infected with HIV-1 drug resistant strains , and to investigate if there are drug-resistant HIV-1 strains transmitted among infected subjects before antiretroviral therapy in Guangdong Province .

前两种基因突变型所致的临床表现无明显差别，均引起新生儿急性溶血性贫血和黄疸。

There were no significant differences between the clinical manifestations caused by the former two gene mutations , which both caused acute hemolytic anemia and jaundice .

正常情况下，由于长时间的进化，前病毒发生了突变不能合成蛋白，从而其天然宿主不致病。

Normally , with a long period of evolution for host , PERV proviral DNA in host cell mutated and thus can not synthesize protein , so the pig does not ill with PERV .

冻干大鼠肝S9对前致癌物/前致突变物的代谢活性研究

Study on the Metabolic Activity of Lyophilized Liver S9 Fraction for Precarcinogens / Prremutagens