别嘌醇

目的探讨别嘌醇致药物超敏综合征（DHS）的临床特征。

Objective To study of the clinical feature of drug hypersensitivity syndrome by allopurinol .

并对别嘌醇双层渗透泵片的Beagle犬体内药物动力学进行了研究。

Then , pharmacokinetic study of allopurinol bi-layer osmotic pump tablets was performed in six beagle dogs .

人工神经网络预测别嘌醇HPMC缓释片药物释放D-苯丙氨酸和别嘌醇是两种具有重要药用价值的化合物。

Using Artificial Neural Network ( ANN ) to quantitatively predict allopurinol release from HPMC sustained release tablets D-phenylalanine and Allopurinol have been widely applied in the pharmaceutical field .

方法回顾分析了23例别嘌醇致DHS患者的临床表现、实验室检查、治疗、并发症及预后。

Methods Retrospective analysis of 23 cases of DHS by allopurinol in-patient department was made in detail , including clinical situation , laboratory examination , treatment , complication and prognosis .

本文以大剂量难溶性药物别嘌醇（Allopurinol）为模型药物，研究制备了双层渗透泵和单层渗透泵两类控释制剂。

In this paper , water-insoluble allopurinol with large dose was selected as a model drug to prepare bi-layer osmotic pump tablets ( BOPT ) and mono-layer osmotic pump tablets ( MOPT ) .

选用聚氧乙烯（PEO），氯化钠作为片心材料，醋酸纤维素（CA），聚乙二醇2000（PEG2000）为包衣材料，丙酮为包衣溶剂，制备了别嘌醇双层渗透泵型控释片。

In the preparation of allopurinol BOPT , polyethylene oxide ( PEO ) and sodium chloride were used as the tablet core . Cellulose acetate ( CA ) and polyethylene glycol 2000 ( PEG 2000 ) were selected as the coating materials and acetone was employed as the coating medium .

方法：收集有关别嘌醇不良反应的文献，总结归纳别嘌醇引起的不良反应。

Methods : Collecting and analysis the adverse reactions of allopurinol .

别嘌醇致药物超敏综合征23例临床分析

Clinical Analyses of 23 Cases of Drug Hypersensitivity Syndrome by Allopurinol

D-苯丙氨酸和别嘌醇是两种具有重要药用价值的化合物。

D-phenylalanine and Allopurinol have been widely applied in the pharmaceutical field .

用二阶导数示波极谱法研究了别嘌醇的测定方法。

Determination method of allopurinol has been studied by the second derivative oscillopolarography .

目的制备别嘌醇缓释片并探讨其释药机理。

Objective To prepare the allopurinol sustained-release tablets and study the release mechanism .

别嘌醇渗透泵控释制剂的研究

Studies on Osmotic Pump Controlled Release Preparations of Allopurinol

别嘌醇致剥脱性皮炎2例

Exfoliative dermatitis due to allopurinol : 2 case reports

目的：评价两种国产别嘌醇片的生物等效性。

Objective : To evaluate the bioequivalence of two preparations of allopurinol tablets .

别嘌醇致上消化道出血死亡

Death from upper gastrointestinal hemorrhage induced by allopurinol

别嘌醇添加治疗难治性癫痫58例疗效观察

An open clinical study of Allopurinol as an add-on therapy for patients with intractable epilepsy

别嘌醇片的生物等效性研究

Study on bioequivalence of allopurinol tablets

华法林与氯沙坦、非诺贝特及别嘌醇伍用致上消化道出血

Upper gastrointestinal hemorrhage associated with concomitant use of warfarin , losartan potassium , fenofibrate and allopurinol

别嘌醇对合并高尿酸血症的慢性心力衰竭患者心功能及运动耐量的影响

Effects of allopurinol on cardiac function and exercise capacity in hyperuricemic patients with congestive heart failure

别嘌醇致急性肝损害

Acute liver damage with allopurinol

睾丸扭转超声表现与别嘌醇药物保护相关性的实验研究

Empirical Study of the Correlation between Ultrasonic Appearances of Testicular Torsion and the Protective Effect of Allopurinol

别嘌醇抗痛风疗法加用塞来昔布致患者尿蛋白阳性

A positive urine protein value occurring in a patient after addition of celecoxib to allopurinol-containing regimen for gout

别嘌醇是目前治疗痛风病的首选药物，而且它还可以用来治疗白血病和肾病，同时它还是合成抗肿瘤药和治疗心血管疾病药物的重要中间体。

Allopurinol is the first choice in the treatment of gout , and it was applied to treatment of leukemia and nephropathy .

本品是40年来首个获准治疗伴有高尿酸血症痛风患者的新药，疗效优于痛风的黄金治疗药物-别嘌醇。

This is the first new drug applicating to treat hyperuricaemia in the past 40 years , which is efficacious better than the therapeutic drug-the golden gout Allopurinol .

药效学研究表明秦皮甲素具有显著的降尿酸作用，对小鼠肾功能无影响，其用药安全性显著高于别嘌醇。

The pharmacodynamic test results indicated that Aesculin has strongly lowering uric acid effect and no damage of renal function , aesculin is more significantly safety than allopurinol in the treatment of hyperuricemia .

HPLC法测定血浆中别嘌呤醇及氧别嘌醇的浓度

Determination the Concentration of Allopurinol and Its Metabolite-oxypurinol in Human Plasma by HPLC