人源化抗体

ELISA和RTPCR证实，恒定区特定位点突变的人源化抗体hu12F6m在CHO细胞中获得了表达。

The expression of humanized antibody containing mutated Fc region ( hu12F6m ) was confirmed by ELISA and RT-PCR .

人源化抗体研究历程及发展趋势

Progression and Direction of Humanized Antibody Research

新型抗EGFR人源化抗体基因的构建和表达

Construction and expression of humanized anti-EGFR antibody

本发明也提供结合至该TF的人源化抗体及其片段。

Also provided are humanized antibodies and fragments thereof that bind to the TF .

要么选择从B细胞产生的众多抗体中筛查，要么通过给小鼠接种然后制备人源化抗体。

You can either sift through human B cells and look for ones that will make the right antibodies or you can vaccinate mice and " humanize " the mouse antibodies .

~（188）Re标记CEA嵌合人源化抗体在荷人结肠癌裸鼠的放射免疫显像研究

Radioimmunodetection of ~ ( 188 ) Re-Labeled Anti-Carcinoembryonic Antigen Chimeric Antibody in Nude Mice Bearing Human Colon Carcinoma

抗CD20人源化抗体的制备及生物学活性鉴定

Preparation and characterization of a humanized anti-human CD20 monoclonal antibody

曲妥珠单抗是一种人源化抗体，用于靶向和阻断HER2的功能，而后者是由特异基因编码的一种蛋白，具有致癌潜能。

Trastuzumab is a humanised antibody , designed to target and block the function of HER2 , a protein produced by a specific gene with cancer-causing potential .

抗血小板人源化抗体的研究进展

Advances in the Studies of Humanized Anti-platelet Antibody & Review

抗巨细胞病毒人源化抗体的研究

Research of Humanized Antibody Against Human Cytomegalovirus

人源化抗体的形式也从最初的嵌合抗体、改型抗体等逐步发展为今天的人抗体。

Humanized antibody has developed from chimeric antibody and reshaped antibody to the present fully human antibody .

它是用基因工程的方法制备人源化抗体，是一种能从各种各样的文库中筛选高质量人源性抗体的稳定而简便的技术。

It is a stable and simple technology to prepare high quality human antibodies by means of genetic engineering .

对这3种抗体初步进行了初步的分析，实验结果表明人源化抗体对肿瘤细胞的生长和迁移具有一定的抑制作用。

The preliminary experimental results show that the three humanized antibodies suppress the growth and migration of tumor cells .

为了降低鼠源抗体引起的超敏反应，治疗性单克隆抗体已由改型抗体，人源化抗体发展到全人抗体。

Therapeutic mAbs has developed from reshaping antibody and humanized antibody to fully human antibody in order to lower supersensitivity resulting from mouse antibody .

采用化学治疗药物（贝伐单抗，是中和血管内皮生长因子的人源化抗体）治疗可导致蛋白尿和肾功能损害。

Treatment with the chemotherapeutic agent bevacizumab , a humanized mAb that neutralizes vascular endothelial growth factor , can lead to proteinuria and renal damage .

本文就血小板在出血和血栓性疾病中的作用，人源化抗体的发展现状和抗血小板人源化抗体在出血性及血栓性疾病中的应用作一综述。

The important role of platelet in bleeding and thrombotic diseases , the present status of development on study of humanized anti-platelet antibody and its application in treatment of bleeding and thrombotic diseases were summarized in this review .

本文介绍了噬菌体展示技术的基本概况，着重阐述了噬菌体展示技术在鸡源性单链抗体、噬菌体随机肽库、人源化抗体以及过敏原的分析、拟糖多肽、蛋白质稳定性等方面的研究。

The article introduces the theory of phage display , stresses the application in chicken single chain antibody , humane antibody , phage peptide library , the anlysis of allergens , the research in glyco-replica peptide and stability of protein .

分子靶向药物bevacizumab是针对血管内皮生长因子（VEGF）的重组人源化单克隆抗体，在多种恶性肿瘤的治疗中显示了临床效果。

The targeted drug bevacizumab is an anti-VEGF monoclonal antibody , it has clinical effect on many malignant tumors .

epratuzumab是抗CD22的人源化单克隆抗体。

Epratuzumab is a humanized anti-CD22 monoclonal antibody .

抗肝癌人源化单链抗体hscFv（25）的体外亲和力成熟

In vitro maturation of humanized single-chain Fv_ ( 25 ) against hepatocellular carcinoma

治疗性人源化单克隆抗体研究进展

Advances in humanized monoclonal antibody for therapeutic uses

本文就噬菌体抗体库技术在制备人源化单克隆抗体、改良抗体性能以及面临的挑战和应用前景等方面进行简要综述。

We here will give a brief description of the development of phage antibody library in producing humanized monoclonal antibody and improving antibody performance , as well as of the challenges it faced and application prospected in the future .

除传统的光化学疗法、放疗、化疗、体外光化学疗法外，维A酸类、干扰素、白介素2融合蛋白、重组白介素12、人源化单克隆抗体等免疫调节剂对早期蕈样肉芽肿有较好的疗效。

In addition to traditional photochemotherapy , radiotherapy , chemotherapy , and extracorporeal photochemotherapy , immunomodulators , such as tretinoins , interferons , interleukin-2 fusion protein , recombinant interleukin 12 and humanized monoclonal antibody may have a good therapeutic effect on the treatment of early stage mycosis fungoides .

人源化CD25单克隆抗体对外周血T淋巴细胞活化和增殖的影响

Effects of Humanized Recombinant CD25 Monoclonal Antibody on Activation and Proliferation of T Lymphocytes

Epratuzumab是人源化的LL2抗体，通过对套细胞淋巴瘤的Ⅰ/Ⅱ期临床试验研究，其有效率为18%，不产生人抗鼠抗体（HAMA）。

Epratuzumab is a humanized LL2 ( hLL 2 ) monoclonal antibody . In phase I / II Trial of the treatment of mantle cell lymphoma , Epratuzumab didn ′ t develope HAMA with the effective power of 18 % .

间接ELISA法测定猕猴血清中重组人源化抗EGFR单克隆抗体的含量

Indirect ELISA Determination of Recombinant Human Anti-EGFR Monoclonal Antibody in Rhesus Serum

人源化抗CD3单链抗体在大肠杆菌中的GST融合表达

The GST-Fusion Expression of a Humanized Single-chain Fv Fragment in E.coli

用抗原表位定向选择方法人源化抗TNF-α抗体Fab段

Humanization of anti TNF α murine Fab with the method of epitope guided selection

定点突变人源化含硒单链抗体酶

Site-directed Mutagenesis of Humanization of Selenium-Containing Single-Chain Abzyme

抗人甲状腺球蛋白人源化单克隆抗体的制备

Preparation of the humanized anti-human thyroglobulin monoclonal antibodies