锌指

本文综述了3种DNA结合蛋白结构域&螺旋－转折－螺旋、亮氨酸拉链、锌指近年来的研究进展。

This article reviews the progress in three DNA-binding protein domains : helix-turn-helix , leucine-zipper and zinc finger .

一种新的人端粒相关锌指蛋白cDNA的克隆及鉴定

Cloning and identification of a new telomeric-associated zinc finger protein cDNA

目前，对大豆中C3HC4型RING锌指蛋白基因的研究不多。

So far , few articles reported C3HC4-type RING zinc-finger protein genes in the soybean .

用BubblePCR法对一个新的锌指基因进行外显子划界

Identification of Exon Boundaries in a Novel ZincFinger Gene Using Bubble-PCR Method

用RACE结合cDNA文库筛选的方法获取新的锌指蛋白基因

Isolation of New Zinc Finger Genes through cDNA Library Screening Combined with RACE

他根据该结合该蛋白的金属种类以及该蛋白结合DNA的方式把该类蛋白命名为锌指蛋白。

He named them zinc-finger proteins , after the metal that holds them together and the way in which they grasp DNA .

C2H2型锌指蛋白的研究进展

Advances in C_2H_2 Zinc Finger Proteins

褐飞虱诱导的水稻cDNA文库的构建及锌指蛋白基因的分离

Construction of Rice cDNA Library Induced by Brown Planthopper and Isolation of Dof Zinc Finger Protein

一直以来，锌指结构域都被认为参与DNA结合并在转录因子中存在。

In the past , zinc finger domain was thought to be involved in the ability of DNA binding and present in transcription factors .

应用简并引物RT-PCR扩增锌指结构域筛选新基因

Identification of New EST and Genes with Zinc Finger Motif by RT-PCR Using Degenerate Primers

K562细胞中锌指蛋白cDNA基因片段的克隆

Molecular Cloning of cDNA Gene Fragments Coding for Zinc Finger Proteins Expressed in K562 Cells

锌指是最大的DNA结合蛋白家族，是最普遍的核酸识别元件。

Within the known classes of DNA binding proteins , the zinc finger is the largest family and the most common motif for nucleic acids recognition .

锌指转录因子snail超家族

The Snail Superfamily of Zinc - finger Transcription Factors

锌指蛋白作为主要的转录调控因子，在RNA的转录过程中发挥着非常重要的调控作用。

As the major transcriptional factors , the zinc finger proteins play very important role during the regulation of RNA transcription .

缺氧损害对锌指蛋白A20和高敏C反应蛋白高表达的影响

Influence of hypoxic damage on the high expression of the zinc finger protein A20 and high sensitivity C-reactive protein

锌指DNA结合区在大肠杆菌中的功能性表达成功为锌指蛋白DNA相互作用的胞内遗传筛选模型的建立奠定了基础。

The functional expression of DNA binding domain of Zif268 will greatly facilitate the development of in vivo genetic selection assay for the study of Zinc fingers-DNA interaction .

苯并[a]芘诱导的FL细胞锌指蛋白等表达的改变

Altered of zinc finger proteins expression in FL cells following benzopyrene treatment

转染锌指蛋白基因A20抑制内毒素诱导的内皮细胞IL-8表达的研究

Zinc finger protein gene A20 inhibits lipopolysaccharide-induced IL-8 expression of endothelial cells

目前正对HIV感染者进行锌指核酸酶临床实验，利用这种酶删除一段使病毒进入免疫细胞的基因。

Clinical trials are underway in HIV patients of zinc-finger nucleases that remove a gene that allows the virus to enter immune cells .

锌指核酸酶是一种人工制做限制性内切酶，通过将锌指DNA结合区与限制性内切酶的DNA切割区融合获得。

Zinc finger nucleases ( ZFNs ) are artificial restriction enzymes made by fusing an engineered zinc finger DNA-binding domain to the DNA cleavage domain of a restriction enzyme .

植物TFⅢA类型锌指蛋白的研究进展

TF ⅲ A-type Zinc-finger Proteins in Plants

Krüppel样锌指转录因子在内皮细胞中的生物学作用

Role of Kr ü ppel-like transcription factors in endothelial biology

利用锌指基序的保守性从人脑组织分离新的C2H2型锌指蛋白基因表达序列

Isolation of novel expression sequences of c_2h_2 type zinc finger protein gene from human brain tissue according to the conservation of zinc finger motif

锌指蛋白A20及其对细胞凋亡的抑制作用

Zinc-finger protein A20 and its implications for suppression of cell apoptosis

然而，由于目前在实验上很多锌指核酸酶的晶体结构很难得到，这样就限制了锌指核酸酶和DNA相互作用的理论研究。

However , since crystal structure of the zinc finger nuclease has not been obtained in experiments , theoretical studies on interactions of zinc finger nuclease with DNA remain very limited .

已知有许多的转录因子是非常重要的MAPK靶基因，锌指蛋白就是中间的一类。

Many transcription factors are important MAPK targets , and zinc finger protein is one of them .

LIM结构域由两个串联的富含半胱氨酸的锌指基元组成，在进化中十分保守。

The LIM domain defines a conserved cysteine-rich structure comprising two tandemly repeated zinc fingers .

近年来，在克隆植物锌指蛋白基因方面取得了很大进展，特别是对于植物TFⅢA类型锌指蛋白的研究。

As many as 30 genes for TF III A-type zinc-finger proteins have been reported from plants so far .

凝胶迁移率移动试验证实纯化的可溶部分锌指DNA结合区可以特异性识别、结合其天然靶序列，提示锌指DNA结合区在大肠杆菌中得到了功能性表达。

The gel mobility shift assay shows that purified DNA binding domain can bind its natural target sequence specifically , which indicates the DNA binding domain remains its DNA binding activity in Escherichia coli .

进一步用部分物种Ikaros的保守区进行同源性比对，发现同源性较高的区域主要集中在N、C末端的锌指结构域。

Further comparison between some species and Ikaros reveals that the regions that show higher homology focus zinc finger domains at N and C-terminal .