异源二聚体

Bax-Bcl-2异源二聚体与胃癌细胞凋亡的关系

Relationship between the level of Bax-Bcl-2 heterodimer and apoptosis of gastric cancer cells

A位点的交配型基因编码两类含相似同源结构域的蛋白质，两种蛋白质形成异源二聚体，调节依赖A因子的发育过程；

The mating type genes in A loci encode two kinds of highly conserved homeodomain containing protein , which play important roles in A dependent development by the formation of protein heterodimer .

EGFR同相应的配体结合形成同源或异源二聚体，从而激活细胞内下游信号传导通路。

Upon binding to corresponding ligands . the EGFR forms homo-or heterodimers and activate downstream signal transduction pathways .

bax为促凋亡蛋白，它可与抗凋亡蛋白bcl-2形成异源二聚体，具有抑制bcl-2，促进细胞凋亡的作用。

Bax is the pro-apoptotic protein , it combines anti-apoptotic bcl-2 protein into heterologous dimer , which can inhibit bcl-2 and promote the cell apoptosis .

EGF受体家族成员通过配体形成同源或异源二聚体，活化胞内酪氨酸激酶，从而激活信号转导通路。

EGFR family members binding with ligands to form homo-dimers or hetero-dimers activate intracellular tyrosine kinase , which further activate cysto-signal transduction pathway .

结论：高、低剂量X射线诱导小鼠腹腔巨噬细胞转录因子NF-κB的DNA结合活性增强以异源二聚体p65/50增强为主。

Conclusion Irradiation with both low dose and high dose of X-rays can induce the increase of the DNA binding activity of NF - κ B predominantly heterodimer p65 / 50 in peritoneal macrophages in irradiated mice .

NAC蛋白通过形成同源二聚体和异源二聚体来决定行使蛋白伴侣或转录共激活子的功能，从而在细胞翻译过程和转录过程之间建立了联系。

NAC proteins form homo-and heterodimers to decide their functions as protein chaperone or transcription coactivator , and make a connection between translation and transcription processes in cell .

PCR-限制性酶切片段-单链构象多态合并异源二聚体分析中国人群的Kell血型系统

Analysis of Kell blood group system using polymerase chain reaction-restriction fragment-single strand conformation polymorphism combined with heteroduplex in Chinese

突变率为4/1000；没有发现PCR-RF-SSCP合并异源二聚体分析有漏检情况。

The mutation rate was 4 / 1000 . No mutation was found as missed in using PCR-RF-SSCP combined with heteroduplex .

另外我们发现Siah-1S不仅可以和Siah-1结合形成异源二聚体，也可以和自身形成同源二聚体。

Additionally , Siah-1S is found to interact with Siah-1 to form heterodimer or with itself to form homodimer .

原癌基因Fra-1是核转录因子AP-1家族的成员，通过亮氨酸拉链结构域与Jun蛋白形成异源二聚体，调控靶基因的转录。

A proto-oncogene Fos-related antigen ( Fra ) - 1 is a FOS family member and an AP-1 transcription factor component . Through their leucine zipper domain , Fra-1 proteins form heterodimers with Jun proteins , which control transcription of target gene .

低氧诱导因子-1是低氧时表达的一种蛋白，由低氧诱导因子-1α和低氧诱导因子-1β组成的异源二聚体。

Hypoxia inducible factor-1 ( HIF-1 ) is a heteroduplex composed of HIF-I α and HIF-1 β, ex - pressed under condition of hypoxia .