纺锤体微管

CaMKⅡ作为Ca2+的下游信号分子，在受精后促进成熟促进因子（MPF）和细胞静止因子（CSF）的失活，并调节纺锤体微管的组装和中心体的复制过程。

As one of the down stream signaling molecules of calcium , CaMK ⅱ facilitates the inactivation of maturation promoting factor ( MPF ) and cytostatic factor ( CSF ) following fertilization , as well as the spindle microtubule organization and centrosome duplication .

它周期性地表达在细胞周期的G2/M期，并通过与细胞有丝分裂纺锤体微管蛋白结合，抑制半胱氨酸蛋白酶3、7（caspase3、7）的活性，从而抑制细胞凋亡。

It regularly expresses in G2 / M phase and suppresses the activity of caspase 3 and caspase ? by binding to the micro-tube protein of the cell mitotic spindle .

纺锤体微管的形态发生了改变，出现了两个纺锤体、巨大纺锤体和多极纺锤体等异常结构。

Abnormal spindles such as two spindles , one large spindle and multi-polar spindles occurred .

纺锤体微管在着丝粒两侧的附着处，与染色体分离密切相关。

Kinetochore & A structure at the centromere to which the spindle fibers are attached .

结果显示：纺锤体微管为核的定位、分离和运动所必需；

Meiotic spindle made up of microtubules is essential to location , separation and movement of chromosomes .

在细胞分裂过程中，染色体的分离是受到纺锤体微管与动点的结合编排调控的。

During cell division , chromosome segregation is orchestrated by the interaction of spindle microtubules with the centromere .

还可通过有丝分裂纺锤体的微管调节细胞周期的G2／M期。

It also regulates the G2 / M phase of the cell cycle by associating with mitotic spindle microtubules .

survivin作为连接凋亡和细胞周期的因子，选择性地表达于G2／M期，定位于有丝分裂纺锤体的微管上，调节细胞的有丝分裂；

Survivin , a molecule for the the interface between apoptosis and cell cycle , is expressed in the G2 / M phase of the cell cycle in a cycle-regulated manner .

Survivin的表达具有细胞周期依赖性，在细胞周期的G2／M期表达，在有丝分裂过程中与纺锤体的微管蛋白相连。

Survivin is expressed in the G2-M phase of the cell cycle in a cell cycle-regulated manner and associates with microtubules of the mitotic spindle .

survivin通过与细胞有丝分裂纺锤体的微管结合，参与细胞基因转录调节。

Survivin is expressed in the Gi / M phase of the cell cycle , associates with microtubules of the mitotic spindle and regulates cell gene transcription .

这些凋亡细胞会呈现出不同程度上的染色体臂解凝集，此时的动粒还与纺锤体的微管结合。

The dying cells exhibited progressive chromosome arm decondensation while the kinetochores were still associated with spindles .

MⅡ期卵母细胞的微管，主要存在于纺锤体上，少量微管出现在第一极体周围；

Microtubules in M ⅱ oocytes mainly existed in the meiotic spindle and a few of them appeared around the first pole body in the oocyte .