蝶呤

方法对100例运动及智能障碍患者进行苯丙氨酸（phenylalanine，Phe）及BH4负荷试验、尿蝶呤谱分析、红细胞二氢蝶啶还原酶测定，并对部分患者进行多巴治疗性诊断；

Methods One hundred patients with unknown motor disturbance and mental retardation were referred to this study . All patients were performed by phenylalanine ( Phe ) and BH4 loading test , urinary pterin analysis and dihydropteridine reductase ( DHPR ) activity .

氨甲蝶呤获得性耐药和DNA甲基化的相关性研究

The study on the relationship between acquired drug resistance to methotrexate and global DNA methylation

方法应用高效液相层析仪对87例高苯丙氨酸血症者进行尿新蝶呤（N）和生物蝶呤（B）分析；

Methods Urinary neopterin ( N ) and biopterin ( B ) was analyzed in87 patients with hyperphenylalaninemia by high-performance liquid chromatography .

方法超声引导穿刺注射氨甲蝶呤（MTX）治疗异位妊娠。

Methods Ultrasound conducts to inject MTX to cure ectopic pregnancy .

方法采用RT-PCR的方法，对小鼠氨甲蝶呤（MTX）抗性细胞系中MTHFR的表达进行分析。

Methods The expression of MTHFR is detected by RT-PCR in the MTX-Resistant mouse cell lines .

方法用毛细管区带电泳技术，以中性环糊精作为氨甲蝶呤拆分选择剂，对环糊精浓度、缓冲液浓度、pH值、电泳温度和改性剂浓度等分离条件进行优化。

Methods By using capillary zone electrophoresis with nature cyclodextrin , we optimized various factors such as concentration of buffer , cyclodextrin and modifier , pH , voltage and temperature .

以霉酚酸酯加环孢素A和短程氨甲蝶呤预防移植物抗宿主病，低剂量肝素和前列腺素E1脂质微球预防肝静脉阻塞病。

Low dose heparin and lipo prostaglandin E 1 were used in prophylactic regimen for hepatic veno-occlusive disease .

小剂量氨甲蝶呤联合GM-CSF对U973细胞的诱导分化作用

Low-dose MTX combined with GM-CSF induces differentiation of monocytic leukemic cell line ( U937 ) in vitro

结果应用介入性超声穿刺注射氨甲蝶呤（MTX）治疗异位妊娠22例，疗效满意。

Results Apply interventional ultrasound to inject MTX to treat 22 cases of ectopic pregnancy and gain the good effect .

苯丙氨酸呼吸试验测定苯丙氨酸羟化酶（PAH）活性能诊断四氢生物蝶呤敏感性PAH缺乏

In vivo studies of phenylalanine hydroxylase by phenylalanine breath test : Diagnosis of tetrahydrobiopterin - responsive phenylalanine hydroxylase deficiency

目的：探讨大剂量氨甲蝶呤（MTX）用药后血药浓度监测的临床意义。

OBJECTIVE To study the clinical significance of monitoring the serum methotrexate concentration ( MTX ) after administration with high dose MTX .

目的：探讨四氢生物蝶呤（BH4）对肾缺血再灌注损伤（IR）模型的作用及其作用机制。

AIM : To investigate the effects and mechanisms of tetrahydrobiopterin ( BH 4 ) on renal ischemia reperfusion injury in rats .

环孢素A和氨甲蝶呤预防移植物抗宿主病（GVHD）。

To prevent graft-versus-host disease ( GVHD ) episodes , cyclosporine-A ( Cs-A ) and methotrexate ( MTX ) were adminstered .

方法对18例急性白血病患者进行了26例次大剂量氨甲蝶呤（HDMTX1～1.5g/m2）治疗护理观察。

Methods : Fourteen cases of patients with acute leukemia treated with HD MTX ( 1 0 ~ 1 5 g / m 2 ) were observed .

叶酸（FolicAcid）系由2-氨基-4-羟基-6-甲基蝶呤、对氨基苯甲酸及谷氨酸组成的水溶性B族维生素，在人体内转化成四氢叶酸，参与氨基酸及核酸的合成。

Folic acid is Vitamin Bc made up of 2-amino-4-hydroxyl-6-methylpterin , para-amino benzoic acid and glutamic acid , transforming into tetrahydro-folic acid in the human body , the ones that participated in formatting amino acid and nucleic acid .

目的本文观察了羟基喜树碱（HCPT）、氨甲蝶呤（MTX）、5氟脲嘧啶（5Fu）和醛氢叶酸钙（LV）联合方案治疗晚期肺腺癌的疗效及毒副作用。

Objective The therapeutic effects and side effects of combined chemotherapy of HCPT , MTX , LV and 5 Fu for Advanced Lung adenocarcinoma were evaluated .

目的探讨四氢生物蝶呤反应性苯丙氨酸羟化酶（PAH）缺乏症这一新的临床变异型在高苯丙氨酸血症（HPA）中的发生率，并进一步了解其PAH基因突变类型。

Objective To get the incidence of tetrahydrobiopterin ( BH_ 4 ) - responsive phenylalanine hydroxylase deficiency among HPAs , and to find the mutations of PAH in these patients .

例如，在厚朴酚键合硅胶固定相（MSP）中分离嘌呤、嘧啶及蝶呤时，除了疏水性作用外，氢键作用还发挥着重要作用。

For example , in the separations of purines , pyrimidines and pterins to these compounds on MSP , hydrogen-bonding interaction played leading roles besides hydrophobic interaction .

目的：总结四氢生物蝶呤（BH4）缺乏症的临床表现、诊断及治疗。

Objective : To evaluate the clinical manifestations , diagnosis and treatments of patients with tetrahydrobiopterin ( BH 4 ) deficiency .

目的了解大剂量氨甲蝶呤（HD-MTX）化疗引起皮肤损伤的临床特征，并探讨其发生机制。

Objective To study the clinic features and the mechanism of skin damage induced by high-dose methotrexate ( HD-MTX ) .

目的四氢生物蝶呤（BH4）可以使BH4缺乏症病人的血液苯丙氨酸水平正常化，但是对苯丙酮酸尿症（PKU）病人无效。

Objective Tetrahydrobiopterin ( BH4 ) is known to normalize blood phenylalanine levels in BH4 deficiency , but not in phenylketonuria ( PKU ) .

目的：研究单剂量肌肉注射氨甲蝶呤（MTX）治疗异位妊娠（EP）的药动学及药效学，为给药方案的选择提供理论依据。

OBJECTIVE : To study the pharmacokinetics and pharmacodynamics of single dose of intramuscularly injected methotrexate ( MTX ) in the treatment of ectopic pregnancy so as to provide theoretical bases for the choice dosage regimen .

西医采用肌肉注射氨甲蝶呤（MTX）0.4mg/kg·d×5d，为1个疗程，治疗过程中隔日复查血βhCG，疗程结束未降至正常者待5d后重复第2个疗程。

Western medicine adopted fist butterfly of intramuscular injection ammonia purine methotrexate for injection ( MTX ) 0.4mg/kg . d × 5d . It was the fist course of treatment .

方法：利用放射对血-脑屏障的影响，静脉注射氨甲蝶呤（MTX）探讨脑部，照射前、中、后，MTX血-脑屏障渗透吸收变化。

METHODS : Since radiation had some effect on blood-brain barrier , so MTX was injected intravenously to study the changes of permeation and absorption of MTX by blood-brain barrier before , during and after irradiation .

在超声引导下，经阴道后穹隆穿刺未破裂异位妊娠囊，抽尽囊液后，注入氨甲蝶呤（MTX）20~40mg。

Under the guidance of ultrasonography , needle puncture and aspiration of lesions of ectopic pregnancy was conducted through the posterior fornix . Then the methotrexate ( MTX ) 20 ~ 40 mg was injected into .

所有患者均经尿蝶呤谱分析、BH4口服负荷试验及红细胞二氢蝶呤还原酶测定，确诊为BH4缺乏症。

All cases were diagnosed as BH4 deficiency by analysis of urinary pterins profile , BH4 loading test , and determination of dihydropteridine reductase in RBC .

41例尿蝶呤及DHPR活性均正常。

Urinary biopterin percentage and DHPR activity were all normal in 41 patients , so they were ruled out BH_ 4 deficiency .

11例中4例作了苯丙氨酸及BH4联合负荷试验，在口服四氢生物蝶呤后4-6小时，他们的血苯丙氨酸水平降至正常。

Combined loading tests with phenylalanine and oral BH4 were done in 4 of 11 patients and their phenylalanine levels were decreased to normal 4-6h after BH4 administration .

目的得出我国南方高苯丙氨酸血症（hyperphenylalaninemia，HPA）者四氢生物蝶呤（tetrahydrobiopterin，BH4）缺乏症的发病率，总结BH4缺乏症者基因突变和临床转归的研究。

Objective To find out the incidence of tetrahydrobiopterin deficiency ( BH4D ) among patients with hyperphenylalaninemia in Southern Chinese and evaluate the clinical outcome and gene mutations of tetrahydrobiopterin deficient patients .

氨甲蝶呤供者预处理对致敏大鼠移植心脏成活的影响

Prolonged Survival of Rats Cardiac Allografts After Donor Pretreatment with Methotrexate