肾脏纤维化

TIMP-1通过炎症途径促进衰老相关肾脏纤维化的机制研究

Mechanisms of Age-related Renal Fibrosis Promoted by TIMP-1 Through Inflammatory Pathway

细胞外基质（ECM）积聚是肾脏纤维化的最终途径。

Extracellular matrix ( ECM ) accumulation is the final pathway to renal fibrosis .

肾脏纤维化是终末期肾脏疾病的共同途径，CTGF在肾脏纤维化过程中起到关键作用。

Renal fibrosis is the common pathway of ESRD , CTGF acts as a crucial factor in the process .

重组人红细胞生成素改善UUO大鼠肾脏纤维化的研究

Protective Effect of Recombinant Human Erythropoietin in Renal Tubulointerstitial Fibrosis with UUO in Rat

miR-21可能参与了高血压致心肌肥厚及肾脏纤维化的病理过程。

MiR-21 may be involved in the pathological processes of hypertensive cardiac hypertrophy and renal fibrosis .

目的：结缔组织生长因子（CTGF）可以促进肾细胞增殖、分化及细胞外基质积聚，其异常表达在是肾脏纤维化进程中起着重要作用。

Objective : Connective tissue growth factor ( CTGF ) has been implicated in the process of renal fibrosis by stimulating renal cell proliferation and accumulation of extracellular matrix .

NO-1886调节2型糖尿病小型猪糖、脂代谢紊乱，抑制肾脏纤维化

Lipoprotein Lipase Activator NO-1886 Ameliorates Disorders of Glucose and Lipid Metabolism and Alleviates Renal Fibrosis in Type 2 Diabetic Minipigs

目的：探讨骨调素（OPN）和单核细胞趋化蛋白（MCP1）在大鼠梗阻性模型中的表达及其在肾脏纤维化发病机制中的作用。

Objective : To investigate the expression and function of OPN and MCP-1 in the kidney after unilateral ureteral obstruction in rats .

有研究提示，ERK信号通路是细胞信号中传递丝裂原信号的关键激酶，与肾小管上皮细胞转分化和肾脏纤维化密切相关。

Some studies suggest that , ERK signaling pathway is the key mitogen kinase of cell signals which transfer mitogen signals , and it is closely related to tubular epithelial myofibroblast transdifferentiation and renal fibrosis .

研究表明某些炎性介质，如细胞间粘附分子-1（ICAM-1），也是MMPs的作用底物，提示TIMP-1可能通过影响炎症而促进衰老相关的肾脏纤维化。

It has been shown by some studies that some inflammatory mediators , such as intercellular adhesion molecule-1 ( ICAM-1 ), are substrates of MMPs , therefore , TIMP-1 might promote age-related renal fibrosis through influencing inflammation .

结论：穴位埋线和中药改善CRF的作用机制与降低PTH、抑制TGF-β1的表达、降低MDA含量、阻止肾脏纤维化病变有关。

Conclusion The mechanism of acupoint thread implantation and Chinese herbs in improvement of CRF is related with decrease of PTH , inhibition of TGF - β _1 expression , decrease of MDA content and resisting lesion of renal fibrosis .

结论FRA、FN、α2-PI、PLG在肾组织内的共同表达及协同作用，是促进肾脏纤维化或硬化进行性发展的重要因素。

Conclusion The expressions and correlations within renal tissues of FRA 、 FN 、α 2-PI 、 PLG indicate these are significant factors in the developments of renal tissue fibrosis or cirrhosis .

【目的】肾脏纤维化是各种原因引起的慢性肾脏病变最后共同的结局，最终导致终末期肾功能衰竭（ESRF）。

【 Objective 】 Renal fibrosis is the common pathway of a variety of progressive renal disease to the end stage renal fairlure ( ESRF ) .

目的：转化生长因子-β1（TGF-β1）、一氧化氮（NO）和血管紧张素Ⅱ（AngⅡ）是血管内皮细胞衍生的重要的血管活性物质，与心室重构、心肌肥厚和肾脏纤维化密切相关。

Objective : Transforming growth factor - β ( TGF - β), nitric oxide ( NO ) and angiotensin II ( AngH ) are the important active factors derived from the endothelial cells . They have closely relationship with the ventricle remodeling processes , myocardial hypertrophy and renal fibrosis .

糖尿病肾病大鼠肾脏纤维化逆转可能性的研究

Study on the possibility of renal fibrosis reverse in diabetic nephropathy rats

肾脏纤维化的病理改变主要包括肾小球硬化和小管间质纤维化。

Pathological changes of the renal fibrosis include glomerulosclerosis and tubule-interstitial fibrosis .

盐酸贝那普利对自发性高血压大鼠肾脏纤维化的影响

Effect of benazepril on renal fibrosis in spontaneously hypertensive rats

依那普利联合缬沙坦对慢性肾功能衰竭大鼠肾脏纤维化的影响

Effects of enalapril and valsartan on renal fibrosis of chronic kidney failure rats

肾脏纤维化，则属肾络病。

Renal fibrosis , renal meridian-collateral disease .

肾素促肾脏纤维化作用研究进展&肾素-血管紧张素系统的新扩展

Research Progress of Renin in Promoting Renal Fibrosis & New Development of the Rennin-Angiotensin System

组织型转谷氨酰胺酶与肾脏纤维化

Tissue Transglutaminase and Renal Fibrosis

目的观察盐酸吡咯列酮对单肾切除的糖尿病大鼠肾脏纤维化的影响，并从纤维化相关基因表达改变的角度探讨其机制。

Purpose To study the effects of pioglitazone on the renal fibrosis of uninephrectomized diabetic rats and its possible mechanisms .

肾脏纤维化是所有慢性肾脏疾病发展的最终结果，是导致终末期肾功能衰竭的主要原因之一。

The renal fibrosis is the end-result of all chronic renal disease and the primary cause of the end-stage chronic renal failure .

研究背景：铅是一种常见的工业毒物和环境污染物，铅性肾病为中毒职业人群死亡原因的第二位。研究资料显示铅性肾病患者中几乎都有肾脏纤维化的改变。

Background : Lead is well recognized as an environmental and occupational pollutant and chronic lead nephropathy remains the secondly cause of mortality in occupational people .

结论磷酸化P42/p44丝裂原活化蛋白激酶在慢性肾功能不全大鼠模型的肾组织中活性明显升高，可能是慢性肾功能不全时各种细胞外刺激因素介导肾脏纤维化的重要途径之一。

Conclusion Activated P42 / p44 MAPK pathway may , in part , play a role in the pathogenesis of renal fibrosis of chronic renal failure .

研究报道，肾脏纤维化时Wnt/β-catenin信号通路异常活化，提示其可能是抗纤维化的一个潜在的治疗靶点。

Because aberrant activation of Wnt / p-catenin signaling occurs in the fibrotic kidneys , this pathway might be exploited as a potential target for anti-fibrosis therapy .

无论是各种原发性肾小球疾病，还是糖尿病、输尿管阻塞，肾功能的损害都与肾脏纤维化病变的程度密切相关。

No matter what kind of primary glomerulopathy , diabetes mellitus , or ureter blockage , the impairment of renal fuction correlated closely with the extent of renal fibration .

目的：肾脏纤维化是各种慢性进展性肾脏疾病发展至终末期肾功能衰竭的共同病理表现，其主要病理变化为肾小球硬化及间质纤维化。

Objective : Renal fibrosis is a common pathology process of final stage of chronic progressive kidney disease . Its main pathological change is glomerular sclerosis and interstitial fibrosis .

而肾脏纤维化是慢性肾病发展的最终结果，因而降低血尿酸和抑制肾纤维化的发展是防治这两种疾病的有效途径。

Nephros-fibrosis is the end of development of chronic nephropathy , so decreasing blood uric acid and inhibiting development of nephros-fibrosis are the effective way of prevention and curing on the two diseases .

提示整合素连接激酶可能涉及到老龄肾脏的纤维化过程或衰老过程。

The results suggested that ILK might be involved in fibrotic process or senescent process in aging kidney .