生发中心

每个滤泡含有一个大量快速增殖的B细胞和吞噬细胞的构成的生发中心。

Each follicle contains a germinal center populated by rapidly proliferating B cells and macrophages .

结论经典型Hodgkin淋巴瘤的H/RS细胞为生发中心后期分化的B细胞起源；

Conclusion H / RS cells of classical Hodgkin lymphoma were originated from later stage germinal center developed B cells .

弥漫大B细胞淋巴瘤，来源于生发中心外活化的B细胞。

This is a diffuse large B-cell lymphoma with high proliferative activity .

人体淋巴结和扁桃体生发中心内B淋巴细胞免疫细胞化学的研究

A cytochemical study of B cells in germinal center of human lymph node and tonsil

单细胞分离及单细胞PCR技术在淋巴结生发中心研究中的应用

Preliminary Study of Single Cell Isolation and Single Cell PCR in Lymph Node Germinal Centers

此外，抗B细胞及其亚群单抗与扁桃腺、淋巴结、脾白髓生发中心呈强阳性反应。

In addition McAbs of B cells and it 's subsets were reacted very strong with the germinal center of tonsil and lymph nodes and spleen white pulp .

结果HE染色见烫伤小鼠PP结生发中心有大量淋巴细胞凋亡。

Results HE staining revealed that there were relatively abundant apoptotic cells scattering in Peyer 's patches of scalded mice .

核因子-κB活性对BXSB狼疮小鼠脾脏自发性生发中心形成的影响

Role of NF - κ B activation on spontaneous formation of germinal centers in spleen in BXSB mice

结果：TUNEL法显示扁桃体的细胞程序性死亡多集中在淋巴滤泡生发中心；

Results : TUNEL revealed that apoptotic cells were mostly concentrated in the germinal center .

3种标记物在淋巴结中的分布大致相同，主要分布在副皮质区的T细胞、淋巴滤泡生发中心B细胞及巨噬细胞等部位。

These 3 molecules had a similar distribution in germinal center of lymph nodes , mainly in the cells of paracortical region , the cells in germinal center of lymph follicles and macrophages , etc.

Bcl－2主要分布在次级淋巴小结的帽状区，生发中心阴性。

Bcl 2 protein mainly distributed in the mantle zone of secondary follicles , while germinal center was negative .

同时对转录因子E2F1作为一种新的生发中心B细胞型DLBCL的判断指标的可行性进行探讨。

Whether E2F1 can be used as a germinal center B cell DLBCL marker was also discussed .

相反，生理性淋巴滤泡中，Bcl－2蛋白则主要分布于套区，生发中心均为阴性。

On the contrary , in reactive lymphoid follicles Bcl-2 protein was predominantly anchored in mantle zones whereas germinal center cells were unstained .

但有关HRS细胞表型的研究表明，HRS细胞与其起源的生发中心B细胞在表型上有很大不同。

However , studies on phenotypes of HRS cells show that HRS cells are obviously different from its origin , B lymphocytes in germinal center in phenotypes .

目的检测溶酶体蛋白酶CathepsinD在滤泡型淋巴瘤（FL）和淋巴滤泡过度增生（FH）生发中心的表达。

Objective To study the expression of aspartic proteinase cathepsin D in the germinal center of follicular lymphoma and follicular hyperplasia .

淋巴结反应性增生中生发中心B细胞胞质大量表达bcl蛳10，边缘区中等量表达，在套区B细胞较少表达；

In activited lymph follicles , cytoplasmic expression of bcl - 10 protein was abundantly in the germinal center B cell , moderately in the marginal zone , and rarely in the mantle zone B cell .

病理学检查，ZY－1组淋巴滤泡和生发中心呈激活状态，为淋巴滤泡增生阶段，而AZT组则滤泡消失，组织萎缩，出现耗竭现象。

Pathologic examination : lymph follicle and germinal center activated , while in AZT group showed depletion .

BDNF除具有与NGF相似的分布特点外，还见于脾淋巴小结生发中心的淋巴细胞样细胞；

BDNF showed a similar distribution pattern with that of NGF , in addition , it was also identified in the lymphocytes of germinal center of splenic follicles .

GCB型和non-GCB型分别来源于正常生发中心B细胞或活化的外周血记忆B细胞，具有独特的基因表达谱。

GCB type and non-GCB type is original from normal germinal B cell and activated peripheral B cell respectively , and they have different gene expression profiling .

结果在10例FL标本中，CathepsinD阳性信号较弱，位于瘤性滤泡生发中心树突状细胞浆内。

Results Cathepsin D was weakly expressed in the plasma of dendritic cells and histiocytes in the germinal centers of 9 out of 10 cases of follicular hyperplasia .

这些数据说明MFG-E8在生发中心的凋亡B细胞的清楚上有很重要的作用，其功能异常将导致自身免疫疾病。

These data demonstrate that MFG-E8 has a critical role in removing apoptotic B cells in the germinal centers and that its failure can lead to autoimmune diseases .

结果：1.所有RA病例的滑膜组织中均显示中等量或大量淋巴细胞浸润，92.5%（37/40）的病例出现淋巴细胞灶性聚集，甚至出现生发中心，形成淋巴滤泡样结构。

All of the RA cases showed a large number of lymphocytes infiltration in the synovium , 92.5 % ( 37 / 40 ) cases showed lymphocytes ' focal gathering , even appearing germinal center and forming lymphatic follicular sample structure .

结果正常淋巴结被膜下分布着多个生发中心，其内可见FDC网络，与CD20+B细胞分布一致；

Results Many germinal centers were observed under lymph node capsule , in which FDC networks were found with the same distribution of CD20 + B cells ;

结果（1）SHP-1的正常表达部位在淋巴结和扁桃体生发中心的套区和边缘区及部分的滤泡间区，脾脏主要在边缘区及部分动脉周围淋巴鞘；

Results ( 1 ) In relatively normal lymph nodes and tonsils SHP-1 was strongly expressed in the mantle and marginal zones , partly interfollicular zones .

目的探讨T1-2期乳腺癌患者腋窝淋巴结生发中心增生（GH）和窦组织细胞增生（SH）与淋巴结转移的关系。

Objective To explore the relationship between sinus histiocytosis ( SH ) and germinal center hyperplasia ( GH ) in axillary lymph nodes and lymph node metastases of breast cancer of T1-2 stage .

结果17例RLH生发中心细胞、10例滤泡性淋巴瘤（FL）及4例弥漫性大B细胞淋巴瘤（DLBCL）中等强度表达BCL-6；

RESULTS BCL 6 was expressed moderately in cells within the germinal center of the 17 cases of RLH , in 10 cases of follicular lymphoma ( FL ) and in 4 cases of diffuse large B cell lymphoma ( DLBCL ) .

OX40／OX40L介导的共刺激信号，参与了T细胞的活化、增殖和迁移，维持T细胞的长期生成，以及协同CD28信号促进生发中心的形成。

Engagement of OX40 / OX40L promotes T cell activation , proliferation and migration , increases the life-span of effector T cells and enhances the germinal center ( GC ) formation in a CD28-dependent manner .

ACTH与5-HT阳性标志物在2组淋巴结炎组织中分布大致相似，主要位于副皮质区的T淋巴细胞、淋巴滤泡生发中心细胞及巨噬细胞等部位，但表达强度有显著性差异（P<0.05）。

ACTH and 5-HT positive markers in the lymphadenitis tissue of the two groups showed similar distribution , mainly in cortex of lymph gland T lymphocytes and lymph follicle germinal center cellulae and macrophages etc , but expressive intensity had significant difference ( P < 0.05 ) .

北京鸭胚胎期外科切除腔上囊抑制了脾的发育，主要是生发中心、围鞘毛细血管淋巴鞘（PELS）等腔上囊依赖区的发育。

The surgical bursectomy of White Peking Duck embryos inhibited the development of spleen , mainly the development of the germinal center and the periellipsoidal lymphatic sheath ( PELS ) as bursa-dependent areas in spleen .

38/51（74.5%）DLBCL中可见bcl-6蛋白细胞核表达，表达形式有滤泡样型、中间型、散在型，RLH中可见生发中心细胞均呈bcl-6阳性表达；

The bcl-6 expression in the nuclei was found in 38 / 51 ( 74.5 % ) DLBCL , showing different expression patterns including GC / FL type , intermediate type and sporadic type . The bcl-6 was expressed in the GC cells of RLH .