泛素蛋白

泛素蛋白连接酶MDM2活性及稳定性调控的研究进展

Progress in regulation of activity and stability of ubiquitin protein ligase MDM2

泛素和类泛素蛋白就是其中一种。

One such modification is conjugation to ubiquitin and ubiquitin-like proteins ( Ubl ) .

分子遗传学研究证明parkin基因是常染色体隐性遗传性少年型帕金森综合征（ARJP）的致病基因，其表达产物parkin蛋白具有E3泛素蛋白连接酶活性。

It has been identified that parkin gene is the causative gene of autosomal recessive juvenile parkinsionism ( AR-JP ) . The parkin gene product , parkin protein , has ubiquitin-protein ligase ( E3 ) activity .

最近的研究已经被证实：IAPs不仅与细胞凋亡的规则有关，还在细胞分裂中起非常重要的作用，泛素蛋白水解途径，MAPK促分裂原活化蛋白激酶和NF-κB信号途径[11]。

Recent research has proved : IAPs not only play important roles in regulating cell apoptosis , but also widely participate in the process of mitosis , ubiquitin-proteasome pathway , MAPK mitogen-activated protein kinase and NF - κ B signaling pathways .

类泛素蛋白SUMOs是泛素样蛋白家族成员之一，广泛存在于真核细胞中，SUMOs在高等脊椎动物中已有大量研究，而在无脊椎动物中研究较少。

SUMO is a member of the family of ubiquitin-related proteins which widely found in eukaryotes . SUMOs have been extensively studied in higher vertebrates while invertebrates have received little attention .

类泛素蛋白&SUMO

SUMO , a Ubiquitin-related Protein

泛素蛋白在牛早期孤雌胚胎的各阶段均表达，绿色荧光在整个胞质呈广泛性分布，细胞膜下和细胞核区绿色荧光略强于细胞质。

Ubiquitin-protein expression in various stages of the cattle early parthenogenetic embryos showed extensive distribution of green fluorescence throughout the cytoplasm , nucleus and membrane is higher than in cytoplasm .

这些基因编码蛋白参与电子和质子转运、泛素&蛋白体途径以及表观遗传调控（epigeneticregulation）等。

These fragments encode proteins involved in electron transfer and proton transport , the ubiquitin-proteasome pathway , and epigenetic gene regulation .

这些结果表明，在干旱条件下DOR作为耐旱负调控因子参与泛素/26S蛋白小体降解途径来抑制气孔关闭。

Taken together , these results suggest that the ubiqutin / 26S proteasome-mediate proteolysis mediated by DOR acts a negative regulator of drought tolerance by inhibiting the stomatal closure under drought stress .

类泛素样蛋白4与1型糖尿病

SUMO , a Ubiquitin-related Protein SUMO 4 and type 1 diabetes

菊花泛素延伸蛋白基因启动子DgUEP的克隆和功能初探

Cloning and Characterization of an Ubiquitin-Extension Protein Gene Promoter from Chrysanthemum

目前对它的研究主要集中在对谷氨酰胺转移酶和泛素-蛋白水解酶复合体途径的研究两个方面。

Researches about it are focus on transglutaminases and Ubiquitin-proteasome pathway .

就3种基因的变异与泛素-蛋白体系统之间的相互关系作一综述。

This review focuses the relationship between the three gene mutant action and the ubiquitin-proteasome system .

泛素-蛋白水解酶复合体通路与病毒侵染

Ubiquitin-proteasome Pathway and Virus Infection

腈水解酶、泛素转移蛋白、环菲林、亮氨酸氨肽酶反义基因的嵌合载体构建

Construction of Chimeric Vectors of Antisense Nitrilase , Ubiquitin Carrier Protein , Cyclophilin and Leucine Aminopeptidase Genes for Transformation

此损害导致大量多泛素化蛋白的积聚和线粒体功能障碍（被公认的细胞死亡的媒介）。

This impairment resulted in massive accumulation of polyubiquitinated proteins and of dysfunctional mitochondria which are the putative mediators of cell death .

这提到一个在所有细胞中都存在的路径，一个被命名为泛素的蛋白结合细胞蛋白并使它们降解。

This refers to a pathway in all cells whereby a protein aptly named ubiquitin binds to cellular proteins and marks them for degradation .

泛素对蛋白的修饰又叫泛素化，它能极大地影响很多细胞内调控过程，该发现获得了2004年诺贝尔奖。

Modification of proteins by ubiquitin-the so-called ubiquitylation-is of greatest importance in many regulatory processes in the cell and its discovery was awarded the Nobel Prize in2004 .

获得了以下结果：（1）采用VIGS技术分析了泛素融合降解蛋白（ubiquitinfusionprotein，18-8）基因对植物抗病和抗逆性的调控功能。

The main results were as follows : ( 1 ) Role of the ubiquitin fusion degradation protein ( 18-8 ) gene in regulation of plant disease and stress resistance was analyzed by VIGS technique .

泛素在目标蛋白上形成多分子长链是多聚泛素化的开始。

Ubiquitin can form chains consisting of several molecules attached to a target protein to form polyubiquitylation .

烧伤脓毒症早期膈肌内泛素基因和蛋白的表达变化及意义

Expression of mRNA and protein of ubiquitin in diaphragmatic muscle in burned rats with sepsis in early stage

青岛文昌鱼泛素/52氨基酸融合蛋白AmphiUb52的研究

Molecular cloning and phylogenetic analysis of the amphioxus ubiquitin / 52 amino acid fusion-protein gene

目的：探讨烧伤脓毒症时大鼠膈肌内蛋白降解信号分子&泛素的基因和蛋白表达变化及意义。

Objective : To study the expressions of mRNA and protein of ubiquitin in diaphragmatic muscle in burned rats with sepsis .

在本文中，我们讨论了那些与细胞自噬以及蛋白酶体系统相关联的分子机制，并讨论了在选择性自噬作用中，泛素与泛素结合蛋白的新兴作用。

Here , we discuss the molecular mechanisms that link autophagy and the proteasome system , as well as the emerging roles of ubiquitin and ubiquitin-binding proteins in selective autophagy .

真核生物内，泛素和类泛素蛋白在很多进程中发挥了重要的作用，包括蛋白酶介导的水解，异染色质的重塑，蛋白运输等。

In eukaryotic cells , the conjugation of ubiquitin ( Ub ) and ubiquitin-like ( Ubl ) proteins to protein targets plays an integral role in a wide variety of processes , including proteasome-mediated proteolysis , heterochromatin remodelling and protein trafficking .