氯丙嗪

氯丙嗪对耐药细胞系K（562）/AO2多药耐药逆转作用的研究

Reversal effects of multidrug resistance by chlorpromazine in K_ ( 562 ) / AO_2 cell line

盐酸氯丙嗪注射液的HPLC测定

HPLC determination of chlorpromazine hydrochloride injection

氯氮平组和氯丙嗪组的胆固醇和甘油三酯浓度均高于治疗前，差异均有统计学意义（P均<0.01），氟哌啶醇组则无明显变化。

The blood cholesterol and triglyceride level increased in clozapine and chlorpromazine group after treatment ( P < 0.01 ), but not in haloperidol group .

氯丙嗪用作S2O8~（2-）离子的微量快速检定

The micro fast determination of chlorpromazine as s_2o_2 ~ ( - 8 ) ion

东海外缘碎屑矿物的物源解释&基于BP神经网络的判识分区人工神经元网络用于复方氯丙嗪的含量测定

Zonation of detrital sediments distribution on the outer East China sea & determined by using BP artificial neural network analysis

CPA矩阵法测定复方氯丙嗪中二组分含量

Determination of two-component content in compound tablets of chlorpromazine with CPA matrix method

第四章运用盐酸氯丙嗪与DNA的相互作用，制备出性能较好的DNA电化学传感器。

An indicator type of a high performance DNA electrochemical biosensor was prepared by the reciprocity between chlorpromazine hydrochloride and DNA in the fouth chapter .

目的研究文拉法辛联合氯丙嗪治疗精神病性抑郁症（PD）的疗效及其安全性。

Objective To study the efficacy and safety of venlafaxine combined with chlorpromazine in the treatment of psychotic depression .

前言：目的：探讨硫酸亚铁预防氯丙嗪所致锥体外系（EPS）不良反应的疗效和安全性。

Objective : To explore the efficacy and security of ferrous sulfate in the prevention of EPS induced by chlorpromazine .

蛋白激酶C抑制剂氯丙嗪可使脊髓背角神经元放电频率减少，提示蛋白激酶C参与甲醛诱导急性炎症引起的痛觉敏感化的形成。

CP , the inhibitor of PKC , can reduce the discharge frequency of spinal cord dorsal horn neurons , which suggests that PKC is involved in the formation of hyperalgesia induced by acute inflammation .

目的：探讨氯丙嗪对人宫颈癌Hela细胞株的体外抑制作用。

Aim : To investigate the effects of chlorpromazine on cell proliferation of cervical carcinoma cell line Hela in vitro .

利培酮组的WAIS-RC、CT、CMS总分均明显高于氯丙嗪组，差异有显著性。

The total score of WAIS , CT and CMS were significantly higher in risperidone group than in chlorpromazine group .

氯丙嗪组sIL-2R水平明显高于氯氮平组及联合用药组；

The lever of sIL-2R was significantly higher in chlorpromazine group than that in clozapine group and combined drugs group .

结果：氯氮平、氯丙嗪组治疗后TC，TG和LDLc升高非常明显（P<0.01）；

Results : Blood TC , TG , HDL-C , LDL-C levels in clozapine and chlorpromazine groups were much higher than that before the treatment ( P < 0.01 ) .

氯丙嗪较易引起锥体外系反应（EPS），及胆碱能系统不良反应。

There were more adverse effects in chlorpromazine group than in quetiapine group , especially in extrapyramidal side effect ( EPS ) and in choline system .

目的探讨垂体后叶素（PTT）加氯丙嗪联合治疗支气管扩张（支扩）中量咯血的疗效。

Objective To evaluate the effect of pituitrin ( PTT ) combined with chlorpromazine in treatment of patients with hemoptysis caused by bronchiectasis .

提示：氯丙嗪对心肌缺血性膜损伤有保护作用，其机制与抑制PLA2活性及抗自由基的作用有关。

The results suggest that chlorpromazine had a protective effect on membrane damage of ischemic myocardium , which probably resulted from its inhibiting PLA_2 activity and resisting free radicals .

目的对慢性镉染毒（Cd）大鼠投予异搏定（Ver）和氯丙嗪（CPZ），探讨这两种物质对镉慢性肾损伤的影响。

Objective To study the effects of verapamil ( Ver ) and chlorpromazine ( CPZ ) on nephrotoxicity induced by chronic exposure to cadmium .

氯丙嗪对缺氧缺糖PC-12细胞的保护作用及其机制的探讨

Protection of Chlorpromazine on PC-12 Cell Oxygen-glucose Deprived and the Mechanisms Mediated the Effects

处方前研究表明：盐酸氯丙嗪在水、各种pH范围内均易溶；在各种pH范围内，随着pH值升高，油／水分配系数增加，P（app）值范围为5.73～26.38。

The preformulation results showed that CPZ is easily soluble in water and various physiological pH solutions and the n-octanol / water partition coefficients increase with pH rising in various physiological pH solutions ( P_ ( apP ): 5.73-26.38 ) .

合用氯丙嗪和PQP对脑缺血的保护作用

Protection of potassium quercetin phosphate combined with chlorpromazine on cerebral ischemia-reperfusion injury in rats

方法采集115例精神分裂症患者，随机分3组：（1）氯丙嗪组：氯丙嗪400mg·d－1；

Methods 115 subjects were divided into three groups , chlorpromazine group : chlorpromazine 400mg · d - 1 ;

结果显示，小檗胺（E0）及其衍生物（E5、E6）、蝙蝠葛碱（D1）及氯丙嗪（CPZ）在高浓度时均有清除~.OH的作用；

According to the result , Berbamine ( E_0 ) and its derivatives ( E_5 , E_6 ), Dauricine ( D_1 ) and Chlorpromazine ( CPZ ) can decrease ' OH level when at high concentration .

结论：在所选实验条件下用CPA矩阵法测定复方药物中的盐酸氯丙嗪和盐酸异丙嗪简便、快速、准确。

Conclusion : Under the selected experimental condition , the CPA matrix method is simple , quick and accurate in the determination of chlorpromazine hydrochloride and promethazine hydrochloride content in the compound tablets .

实验中，排除了氯丙嗪通过N或M胆碱能神经受体，或影响DOPA脱羧酶活性而减少DOPA生成的可能性。

The work ruled out the possibilities of decrease of DOPA synthesis from the effect on N-or M-cholinergic receptor or from the influence on DOPA decarboxylase activity .

疗后氯氮平组的BPRS、SAPS、SANS总分均明显低于氯丙嗪组（P＜0.01）；

The total scores of the BPRS 、 SAPS 、 and SANS in clozapine group at endpoint were significantly smaller than that of chlorpromazine group ( P < 0.01 );

结论①氯丙嗪（chlorpromazine，CPZ）诱导的PACD小鼠模型符合T淋巴细胞所介导的迟发型超敏反应。

Conclusions ① The mice model of PACD to CPZ is in conformation to delayed-type hypersensitivity induced by T lymphocytes ;

目的：观察蛋白激酶C抑制剂氯丙嗪对甲醛复制的内脏炎症痛大鼠脊髓背角神经元电活动的影响，了解蛋白激酶C在甲醛复制的内脏炎症痛中的作用。

AIM : To explore the effect of chlorpromazine ( CP ), the inhibitor of protein kinase C ( PKC ), on the electric activity of spinal cord dorsal horn neurons evoked by formalin , and understand the effects of PKC on visceral inflammatory pain evoked by formalin .

本研究与常用的血液灌流吸附剂&球状活性炭（SphericalActiveCarbon，简称SAC）比较，研究蒙脱石（Montmorillonite，简称MMT）对常见中毒药物苯巴比妥钠和盐酸氯丙嗪的吸附性能。

Montmorillonite ( MMT ) is expected to apply in blood purification . The absorption performance of MMT for plasma toxics including phenobarbital and chlorpromazine was compared with the performance of spherical active carbon ( SAC ) in this paper .

CaM抑制剂TFP（三氟拉嗪）和CPZ（氯丙嗪）对种根生长、根毛发生和生长均有抑制作用，添加外源CaM可减弱或消除这种抑制作用。

TFP and CPZ ( CaM inhibitors ) also show inhibitory effects on the growth of the seed root and the formation and growth of root hair which can be recovered with exogenous CaM .