氯氮平

人工神经网络结合药动学模型设计氯氮平非pH依赖型缓释片

The application of an artificial neural network and pharmacokinetic models in the design of clozapine pH-inde - pendent tablets

阿立哌唑与氯氮平治疗精神分裂症阴性症状对照研究的Meta分析

Meta-analysis of comparative study in treatment of negative symptom between aripiprazole and clozapine

氯氮平组和氯丙嗪组的胆固醇和甘油三酯浓度均高于治疗前，差异均有统计学意义（P均<0.01），氟哌啶醇组则无明显变化。

The blood cholesterol and triglyceride level increased in clozapine and chlorpromazine group after treatment ( P < 0.01 ), but not in haloperidol group .

人类MICA基因多态与氯氮平致白细胞减少症的关联分析

Association between polymorphism in the Human MICA gene and clozapine-induced leucopenia

心得安、ATP防治氯氮平所致心电图改变的临床观察

Clinical Observation of Prevention and Therapy to Abnormal ECG Caused by Clozapine with Propranolol and ATP

大剂量氯氮平对心电图QT离散度的影响

Effects of high dose clozapine treatment on the QT dispersion ( QTd ) of ECG

RP-HPLC法测定全血、血浆和红细胞中氯氮平及2种主要代谢物

RP-HPLC determination of clozapine and its two major metabolites in whole blood , plasma and red blood cells

各组在停止氯氮平、氟哌啶醇或生理盐水后当日和7d后进行社会行为测验。

Social behaviors were tested on withdrawal day and 7 days after withdrawal .

目的研究氯氮平治疗精神分裂症前后患者血浆及脑脊液中IL-6的变化。

Objective To study the changes of interleukin-6 ( IL-6 ) in the plasma and cerebrospinal fluid ( CSF ) of schizophrenics with clozapine .

治疗前后ISI差值与氯氮平剂量、体重变化无显著相关性。

The decrease of ISI was not correlated with the daily dosage of clozapine and the increase of weight .

氯氮平血药浓度平均为367±93ng／ml。

The mean plasma level of clozapine was 367 ± 93ng / ml.

氯丙嗪组sIL-2R水平明显高于氯氮平组及联合用药组；

The lever of sIL-2R was significantly higher in chlorpromazine group than that in clozapine group and combined drugs group .

结果氯氮平治疗后患者TG明显升高（P<0.01），HDL明显降低（P<0.05）；

Results After clozapine treatment TG levels were increased significantly ( P < 0.01 ) , and HDL levels decreased ( P < 0.05 ) .

氯氮平对慢性难治性精神分裂症的疗效与5-羟色胺2A受体基因的关系

A study on the relationship between the responses to clozapine and the 5-hydroxytryptamine type 2A receptor gene in chronic refractory schizophrenia

结果：氯氮平、氯丙嗪组治疗后TC，TG和LDLc升高非常明显（P<0.01）；

Results : Blood TC , TG , HDL-C , LDL-C levels in clozapine and chlorpromazine groups were much higher than that before the treatment ( P < 0.01 ) .

P300电位变化评估不同剂量氯氮平对精神分裂症患者认知功能的影响

Effect of clozapine of different dosages on the cognitive function in patients with schizophrenia assessed by the changes of P300 potentials

结论：A组中服用氯氮平治疗的患者EEG及BEAM异常程度高，说明药物对大脑功能的损害越广泛、越严重，预后较差；

Conclusions : EEG and BEAM of psychopaths in group A have great difference which prove that Perphenazine tablets and Clozapine tablets damage the function of brain more seriously and the effect is not good ;

目的：比较氯氮平、利培酮对精神分裂症患者血清催乳素（PRL）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）的影响。

Objective : To study the effects of risperidone and clozapine on the serum prolactin , T 3 and T 4 levels .

服氯氮平100mg／d时的4天PRL和29天PRL水平对预测有效剂量没有价值。

Finally , neither day 4 or day 29 the level of PRL can not predict effective dose in clozapine group .

IL一2水平的降低也许可以作为抗精神病药物（尤其是氯氮平）疗效的一个参考指标。

The decreased IL-2 levels of plasma in initial remission may be considered as a reference parameter for the effect of antipsychotic agent ( especially clozapine ) on the immune alternation .

资料显示，氯氮平的口服剂量越大，发生EEG异常及癫疒间的风险就越大、EEG异常程度就越重。

It was showed that the higher daily dose of clozapine was the greater risk of abnormal EEG and seizure may be , and the more severity of abnormal EEG may be .

氯氮平组、奥氮平组的甘油三酯及IR升高程度均为男性大于女性，胆固醇升高程度为女性大于男性；

In clozapine and olanzapine groups , the increased level of triglyceride and IR was significantly higher in male than female , but the increased level of cholesterol was significantly higher in female than male .

氯氮平组患者IL-2水平于4周末、IL-6和IL-18水平于6月末均较治疗前显著下降（P<0.01或0.05）。

In clozapine group , the levels of IL-2 after 4 weeks and IL-6 and IL-18 after 6 months were lowered significantly ( P < 0.01 or 0.05 ) .

为探讨小量氯氮平（25mg）对精神分裂症患者脑电活动的影响与近期疗效之间的关系，对60例精神分裂症患者进行BEAM检测。

BEAM detection were made in 60 schizophrenics to study the relationship between the effect of small dosage clozapine ( 25mg ) on brain electrical activities and short-term effect .

方法应用丁二酸洛沙平与氯氮平进行对照治疗研究，采用PANSS、TESS评定疗效及副反应。

Methods Control studies of loxapine succinate and clozapine were conducted , and curative effects and side effects were evaluated with PANSS and TESS .

方法：通过数据库及手工检索收集1979年至2004年国内有关氯氮平所致EEG异常及癫疒间发作的文献143篇，其中癫疒间发作的个案报道30例。

Method : 143 reports ( 1979-2004 ) were collected by China National Knowledge Infrastructure ( CNKI ) and China Biology Medical Disc ( CBMDISC ) and handwork.30 of them were case reports about seizure .

D4的激动剂喹吡罗对MPTP溃疡模型大鼠胃肠道黏膜的保护作用显著强于阻滞剂氯氮平。

D4 agonist quinpirole could resist the effectiveness of MPTP-induced mucosa injury in rat , while the antagonist clozapine had no such effect .

疗后氯氮平组的BPRS、SAPS、SANS总分均明显低于氯丙嗪组（P＜0.01）；

The total scores of the BPRS 、 SAPS 、 and SANS in clozapine group at endpoint were significantly smaller than that of chlorpromazine group ( P < 0.01 );

目的：探讨与氯氮平对难治性精神分裂症疗效有关的D2受体基因的基因型以及其他相关因素。

Objective : To investigate the relationship between the responses to clozapine for treatment refractory schizophrenic patients and the D 2 receptor gene and the other related factors .

本文报道了用固相萃取技术（SPE）富集分离全血中的氯氮平药物，采用气相色谱氮磷检测器（GC/NPD）分析方法。

This paper reports a simple and rapid method for the isolation of Clozapin drug with solid phase extraction ( SPE ) . The column eluate was analyzed by using GC / NPD .