多巴胺受体

多巴胺受体拮抗剂对AD大鼠的实验治疗学研究

Experimental theraputic studies of dopamine receptor antagonists on rat model of alzheimer 's disease

北极狐多巴胺受体D1基因的克隆测序

Cloning and Sequencing of Dopamine Receptor D1 Gene of Arctic Fox

PD治疗药物中仅多巴胺受体激动剂培高利特与幻觉有显著相关性（P<0.05）。

Pergolide was the only medication that correlated to hallucination ( P < 0.01 ) .

大鼠主动脉和肠系膜动脉多巴胺受体DA1亚型和年龄变化的关系

Age-dependent changes of dopamine DA_1 receptors in aortas and mesenteric arteries of rats

PET和SPECT使无创评价多巴胺受体密度的变化成为可能。

PET and SPECT make possible the assessment by noninvasive means of the changes in dopamine receptor density .

多巴胺受体两个亚家族对大鼠背根神经节GABAA受体的影响

Effect on D1-Like and D2-Like agonist on GABA_A-receptor in rat dorsal root ganglion

3阿朴吗啡（1.6mg·kg~（-1），sc）通过激动延脑催吐化学感受区的多巴胺受体使水貂引起恶心、干呕和呕吐的次数为28.5和5.3（P＜0.01）。

Apomorphine evoked emesis by agitating dopamine receptors of CTZ . The number retching and emesis are 28.5 5.3 ( P < 0.01 ) .

结果：前额皮层星形胶质细胞表达D1多巴胺受体。

Results : D1 dopamine receptor was expressed in rat prefrontal cortical astrocytes .

D2型多巴胺受体配基的研究进展

Recent advances in the structure activity relationship of dopamine D2-like receptor ligands

激活多巴胺受体对大鼠脊髓背角Fos样蛋白生成的抑制作用

Inhibiting action of activation of DA receptors on induction of Fos-like protein in rat lumbar spinal cord

研究表明：典型抗精神病药物治疗精神分裂症的临床效应与其阻断中枢多巴胺受体（DR）有关。

Many studies showed that the clinical effect of typical antipsychotic drugs for schizophrenia is due to their blockage of dopamine receptor ( DR ) .

目的研究多巴胺受体激动剂对乙醇引起大鼠纹状体抗坏血酸（AA）释放的影响。

AIM To study the effects of dopamine receptor agonists on ethanol induced striatal ascorbic acid ( AA ) release in rats .

方法：采用免疫荧光双标，RT-PCR，WESTERNBLOTTING方法观察前额皮层星形胶质细胞D1多巴胺受体的表达。

Methods : The expression of D1 dopamine receptor in cultured rat prefrontal cortical astrocytes was evaluated by immunofluorescence , RT-PCR , western blotting .

结果：紫外分光光度计和荧光分光光度计检测结果以及荧光显微镜下观察结果显示，K562细胞上存在多巴胺受体；

Results : The existence of dopamine receptors in K562 cells was demonstrated by fluorescence microscopy , UV spectrophotometer and fluorescence spectrophotometer .

方法：成熟♀鼠ip多巴胺受体激动剂、拮抗剂或SPD后断头取血，然后用放射免疫法测定血清中的催乳素水平。

METHOD : After ip administration of dopamine receptor agonist , antagonist , or SPD , the serum PRL levels were determined by radioimmunoassay .

肾上腺素能和多巴胺受体在TRH抗兔失血性休克中的作用

Role of adrenergic and dopaminergic ( DA ) receptors in the anti-shock effect of TRH

中国北方老年人多巴胺受体D2基因多态性与吸烟的相关性研究

The study of association of polymorphisms in the dopamine receptor D2 gene with cigarette smoking in elder people of northern China

结论D1和D3多巴胺受体对CREB的磷酸化活化起反式调控作用，并且这种反式调控作用依赖于ERK信号通路。

Conclusion D1 and D3 dopamine receptors can oppositely regulate CREB activation after cocaine treatment and this regulation depends on ERK signaling pathway .

目的：对我国汉族SD患者的多巴胺受体D2基因（DRD2）TaqⅠ多态性进行检测，探讨其与SD的遗传易感性之间的关系。

Objective : To investigate the association between Taq I Polymorphism of Dopamine Receptor D2 ( DRD2 ) and genetic susceptibility for stress disorder .

P1（A1）嘌呤受体，P2嘌呤受体，M胆碱能受体，α2肾上腺素受体，D2多巴胺受体，5-羟色胺受体及H1组胺受体激动剂或拮抗剂可通过突触前机制调节ATP释放。

CONCLUSION : ATP is released from the rat SCG and the release of ATP can be presynaptically modulated by P1 ( A1 ), P2 , muscarinic , α 2 adrenergic , D2 , 5-HT , and H1 receptor agonists and antagonists .

作者证实四氢小檗碱（THB）很可能是一种新的多巴胺受体阻滞剂。

Tetrahydroberberine ( THB ) is a new DA receptor antagonist recently des-cribed by us .

有证据显示，raloxifene在中枢神经系统的多巴胺受体上具有雌激素激动剂的活性。

There is also evidence showing that raloxifene has estrogen agonistic activity on dopamine receptor in the central nervous system .

D3多巴胺受体作为D2类多巴胺受体主要亚型，在肾脏及动脉系统均有表达，起着舒张血管、利钠排尿的作用。

As a major type of D2-like receptor , D3 receptor abundantly expresses in kidney and vessels , stimulation of D3 receptor induces natriuresis , diuresis or vasorelaxation .

借助分子动力学，我们模拟了流动性钠离子及其动态性能对D2多巴胺受体在离子强度作用下的生理反应。

By means of molecular dynamics we simulate the mobility of sodium ions and its effect on the dynamic properties of the D2 receptor under physiological ionic strength conditions .

我们克隆得到了人类多巴胺受体D5基因的一个新亚型D5B。

We have cloned a new subtype of human dopamine D5 receptor ( D5B ) .

本文简要综述了氧化应激在PD发病中的作用，及现有用于PD的抗氧化药物，如多巴胺受体激动剂、还原型谷胱甘肽、人参皂苷Rg1、维生素E和银杏叶提取物的概况。

In this review , the role of oxidative stress in PD and antioxidants such as dopamine receptor agonist , GSH , Ginsenosides Rg1 , Vitamin E , and Ginkgo Biloba Extract ( GBE ) is summarized briefly .

目的：探讨多巴胺受体D2（DRD2）基因多态性在中国北方社区老年人群中的分布及其与吸烟的关系。

Objective : To investigate the possible relationship between dopamine D2 receptor ( DRD2 ) and cigarette smoking in elder people of northern China .

目的：研究热损伤对纹状体多巴胺受体D1R，D2R基因表达水平以及D2R前体mRNA剪接的影响。

Objective : To investigate the effects of hyperthermia on the expression of D_ 1 R mRNA and D_ 2 R mRNA .

目的探讨人体胃、十二指肠是否有多巴胺受体亚型D4和D5的表达及表达的部位。

Objective To investigate the localization and mRNA expression of dopamine receptor subtype D_4 and D_5 mRNA in human stomach and duodenum by in situ hybridization .

Apomorphine的作用能够被多巴胺受体激动剂所模拟或被多巴胺受体拮抗剂所阻止。

The action of apomorphine can be mimicked by dopamine receptor ( D1 and D2 ) agonists or blocked by pre-incubation with the receptor antagonists .