哌拉西林

RP-HPLC法测定注射用哌拉西林钠/舒巴坦钠的含量

Determination of Piperacillin Sodium / Sulbactam Sodium for Injection by RP-HPLC

HPLC法测定配伍后头孢唑林钠、头孢哌酮钠、哌拉西林钠含量的经时变化。

The HPLC was used to measure the ongoing change of content of cefazolin sodium , cefoperazone sodium and piperacillin sodium after compatibility .

RP-HPLC法同时测定哌拉西林和他唑巴坦制剂中两组分的含量

Simultaneous Determination of Contents of Piperacillin and Tazobactam in a Preparation With RP-HPLC

结果：从有效率来看，青霉素-哌拉西林组（L1组）的成本-效果比最小；

RESULTS : The cost-effectiveness ratio of penicillin-piperacillin schemes ( L1 ) was minimum in respect to the effective rate .

头孢哌酮和哌拉西林与β-内酰胺酶抑制剂复方对产酶E.coli和K.pneumonia的抗菌活性及其后效应的研究

A Study on Antimicrobial Activity and Persistent Effects of Combinations Consisted of β - Lactams and β - Lactamase Inhibitors Against β - Lactamase-producing E.coli and K. pneumonia

结果：哌拉西林钠及注射用哌拉西林钠在浓度不大于10mg/ml时对TAL试剂检测无干扰因素的影响。

Result : Piperacillin Sodium and its Injection did not interfere with bacterial endotoxins test when its concentration is not more than 10mg · ml ~ ( - 1 ) .

目的：测定头孢哌酮和哌拉西林与克拉维酸、舒巴坦、三唑巴坦3种β内酰胺酶抑制剂的复合制剂的最小抑菌浓度（MIC）、杀菌曲线。

Objective : To measure the minimal inhibitory concentration ( MIC ), time-kill curve of the composite preparation of β - lactams and β - lactamase inhibitors against β - lactamase-producing Gram-negative bacteria in vitro .

对脆弱拟杆菌，哌拉西林／他唑巴坦MIC90是哌拉西林的1／8。

Against Bacteroides fragilis , the MIC 90 of piperacillin / tazobactam was 1 / 8 than that of piperacillin .

ESBLs产生株对氨苄西林、哌拉西林、奥格门丁及三代头孢菌素高度耐药，除头孢他啶以外，耐药率均在80%以上；

ESBLs-producing strains were much higher resistant to ampicillin , piperacillin , the combination of amoxicillin with clavulanic acid and third-generation cephalosporins , except ceftazidime , the resistant rates were more than 80 % ;

方法哌拉西林钠/他唑巴坦钠3.375g静脉滴注，每12h一次，或亚胺培南/西司他丁0.5g静脉滴注，每12h一次，治疗中、重度肺部感染，疗程为7-14d。

Methods Pipercillin / tazobactam 3.375g iv or imipenem / cilastatin 0.5g iv treated moderate and severe pulmonary infection every 12h for 7 14 days .

产ESBLs株对亚胺培南敏感率达100%，对哌拉西林/他唑巴坦敏感率为67.74%，对头孢噻肟耐药率为80.65%，对头孢他啶耐药率为19.35%。

MIC results showed that the sensitivity of ESBLs producing strains to imipenem was 100 % . And the susceptibility rate to piperacillin / tazobactam was 67.74 % . The resistance rate to cefotaxime was 80.65 % .

结果哌拉西林/他唑巴坦与头孢他啶组的有效率分别为93.8%和81.3%，细菌清除率87.8%和75.6%，两组比较差异有显著性（P0.05）；

RESULTS The effective rate , bacteria eradication rate and bacteria sensitivity rate were 93.8 % , 87.8 % and 83.3 % , respectively in piperacillin / tazobactam group , while the counterpart indexes were 81.3 % , 75.6 % and 79.5 % , respectively in ceftazidime group .

产ESBLs株对亚胺培南均呈敏感，对头孢西丁、头孢哌酮-舒巴坦及哌拉西林-三唑巴坦耐药率较低，对其他抗菌药物的耐药率均较不产ESBLs株高。

All ESBLs producing strains in our study were susceptible to imipenem , and relatively susceptible to cefoxitin , cefoperazone-sulbactam and piperacillin-tazobactam . ESBLs-producers had much higher resistance rates to other antimicrobial agents compared with ESBLs non-producing strains .

产ESBLs菌株对亚胺培南较为敏感（94.8%），其次是哌拉西林/他唑巴坦（36.1%）；而AmpC酶菌株对亚胺培南的敏感率仅为48.4%。

The ESBLs were more sensitive to imipenem ( 94.8 % ), and the next was piperacillin / tazobactam ( 36.1 % ), while the sensitive rate of the AmpC strains to imipenem were only 48.4 % .

与左氧氟沙星、哌拉西林钠、头孢唑啉钠、克林霉素、阿昔洛韦、氨苄西林钠配伍后6h内相对百分含量均>90%；

The percentage of each quantity of the mixture was more than 90 % after zedoary turmeric oil and glucose injection was mixed respectively with levofloxacin , piperacillin sodium , clindamycin , acyclovir , cefazolin sodium and ampicillin sodium for 6 h ;

在ICU，鲍曼不动杆菌对亚胺培南暂无耐药性，其次对头孢吡肟、替卡西林/克拉维酸、哌拉西林/三唑巴坦和阿米卡星的耐药率分别为18%、29%、35%和38%。

The Acinetobacter baumannii have no drug resistance to imipenem in ICU at this time , The drug resistant rate of A baumannii to Cefepime , ticarcillin / clav , piperacillin / tazobactan , and amikacin is 18 % , 29 % , 35 % , and 38 % respectively .

结果样品1∶10及1∶20稀释，选用灵敏度为0.25Eu·ml-1的鲎试剂可以检测样品的细菌内毒素。结论本方法简便、快速、准确，可用于注射用哌拉西林钠的细菌内毒素检查。

Results It was proved that the maximum noninterference concentration was 20 times diluted liquid and the sensitivity of TAL test was 0.25Eu · ml - 1 . Conclusion The method for bacterial endotoxin was accurate and reliable and could replace the pyrogen test .

1.3配伍稳定性考察的样品溶液配制分别取上述三家药厂生产的注射用哌拉西林钠他唑巴坦钠，用0.9%氯化钠注射液配制成10mg/ml哌拉西林钠，1.25mg/ml他唑巴坦钠溶液。

1.3 Preparation for Sample solutions for compatible stability investigation Piperacillin Sodium And Tazobactam Sodium For Injection from the above three manufactures were dispensed by 0.9 % sodium chloride respectively , then 10mg / ml piperacillin sodium , 1.25mg/ml tazobactam sodium can obtained . 2 .

高效液相色谱法测定注射用他唑巴坦钠/哌拉西林钠的含量

Determination of Tazobactam Sodium / Piperacillin Sodium for Injection by RP-HPLC

甲氧苄啶和哌拉西林的耐药率也较低，均为14.3%。

The sensitive rates of trimethoprim and piperacillin were 14.3 % .

哌拉西林钠快速溶解方法的临床研究

Clinical study on ways of speeding up resolution of piperacillin sodium

哌拉西林/他唑巴坦防治烧伤感染的多中心临床试验

A multicenter clinical trial of piperacillin / tazobactam in burn infection

哌拉西林和阿米卡星联用治疗重度院内铜绿假单胞菌肺炎评价

Piperacillin with amikacin in treatment of severe nosocomial pneumonia by Pseudomonas aeruginosa

哌拉西林/他唑巴坦在自发性腹膜炎的临床应用

The Clinical Treatment Experience of Spontaneous Bacterial Peritonitis Using Piperacillin / Tazobactam

哌拉西林/他唑巴坦治疗34例住院患者下呼吸道感染的临床研究

Piperacillin / tazobactam Treatment of 34 Inpatients with Lower Respiratory Tract Infection

毛细管区带电泳法测定哌拉西林钠的含量

Determination of Piperacillin Sodium for injection by capillary zone electrophoresis

结果：哌拉西林钠组方案为最佳治疗方案。

RESULTS : The therapeutic scheme of Piperacillin was the best one .

哌拉西林/他唑巴坦经验治疗神经内科严重感染的观察

Empiric Therapy of Severe Infections by Piperacillin / tazobactam in Neurologic Department

哌拉西林/他唑巴坦在危重病患者感染治疗中的应用

Piperacillin / Tazobactam in Therapy against Infection in Critically Patients

复方哌拉西林钠一般药理研究

Study on general pharmacology of piperacillin sodium / Sulbactam sodium for injection