哌嗪

HPLC荧光法测定人血清中左羟丙哌嗪的浓度

Determination of Levodropropizine in Human Orrhos by HPLC with Fluorimetric Detection

N，N-双（二苯膦甲基）哌嗪和钯配合物的合成及苄基氯的催化羰基化反应

Synthesis of N , N-Bis ( diphenylphosphinomethyl ) piperazine and Its Palladium Complexes and Catalytic Carbonylation of Benzyl Chloride

N，N'-双（膦酰基苯基次甲基）-2-咪唑啉酮及2,3-哌嗪二酮的合成

Synthesis of n , n ' - bis ( o , o-diethylphosphonophe ) - 2 - imidazolinone and 2,3-piperazinedione

HPLC荧光法研究左羟丙哌嗪的人体药动学

Study the Pharmacokinetics of Levodropropizine with HPLC-RIF

N-取代N′-苯基哌嗪类化合物与硫杂蒽酮体系光诱导电子转移引发聚合体系的研究

A study on the photoinduced electron transfer initiation polymerization of MMA by system of N-substituted n ' - phenylpiperazine and thioxanthone

填料塔中碳酸钾/哌嗪混合吸收液脱除CO2的体积传质系数

Volumetric mass transfer coefficients of dilute CO_2 absorption into mixtures of potassium carbonate and piperazine in packed column

苄基哌嗪衍生物的量子化学计算和~（13）cNMR化学位移相关性研究

The quantum chemistry investigation of 1-Benzyl-Piperazine derivatives and its correlation with ~ ( 13 ) C NMR chemical shifts

前言：目的：研究川芎嗪二苯甲基哌嗪衍生物对ECV-304细胞氧化损伤的保护作用。

Objective : To evaluate the protective effect of Ligustrazine bisphenylmethyl piperazine derivatives on ECV-304 cells injured by hydrogen peroxide .

采用HPLC荧光检测法测定血清样品中的左羟丙哌嗪浓度。

A method of HPLC with fluorescence detection was established to determine the concentration of levodropropizine in serum .

抑制HL-60的哌嗪衍生物的合成和生物评价

Synthesis and Biological Evaluation of Piperazine Derivatives for HL-60 Human Leukemia Cells

而以N，N′-双-（3-氨基丙基）哌嗪为连接臂的探针对T·AT三链DNA则有更大的荧光增强（4&10倍）。

Compared with N , N-bis - ( 3-aminopropyl ) amine spacer , N , N ' - bis - ( 3-amino propyl ) piperazine spacer had bigger fluorescence enhancement .

研究表明：氮芥和哌嗪衍生物卟啉能与BSA形成稳定配合物，其结合数都约为1。

Research results showed that porphyrins could bind to BSA to form steady complexes by hydrophobic force .

由不同取代哌嗪合成TEX

Synthesis of TEX from Six Kinds of Different Substituted Piperazine

普通光学显微镜及荧光显微镜观察榄香烯哌嗪对HeLa细胞形态的影响，利用流式细胞仪检测HeLa细胞凋亡及细胞周期变化情况。

Effects of Elemene Piperazine on apoptosis and cell cycle of HeLa cells were evaluated by flow cytometric method .

对自行设计合成的哌嗪类药物进行了毛细管区带电泳（CZE）和高压液相色谱（HPLC）的分离研究。

The CZE and HPLC separation of substituted piperazine designed and synthesized by our research group was investigated .

设计合成了七种新的1，1－二烷基－4－（3－溴丙酰基）哌嗪季铵盐溴化物，通过IR，￣1HNMR和元素分析证实其结构。

Seven new 1,1-dialkyl-4 - ( 3-bromopropionyl ) piperazinium bromides were synthesized . Their structures were elucidated by IR , 1H NMR and elemental analysis .

目的研究榄香烯衍生物（榄香烯哌嗪）对人宫颈癌细胞HeLa体外增殖的抑制作用及其作用机制。

Aim To study the inhibitory effects of Elemene Piperazine on the proliferation of HeLa cells in vitro and the involed mechanisms .

合成出六种取代哌嗪，并以1HNMR、IR和元素分析鉴定了其结构。

Six kinds of substituted piperazine were synthesized , and the structures of these compounds were identified by1HNMR ? IR and elemental analysis .

合成了14种（Z）-1-乙酰基-3-亚芳基（亚烷基）-2,5-哌嗪二酮（4a&n），并讨论了产物的构型。

Fourteen compounds of ( Z ) - 1-acetyl-3-arylidene ( alkylidene ) - piperazine-2 , 5-dione ( 4a - n ) were synthesized . The configuration of products were discussed .

方法采用小鼠S180肉瘤移植性肿瘤动物模型，以抑瘤率为指标考察榄香烯哌嗪的体内抗肿瘤活性。

Methods The pharmacological activity of elemene piperazine was measured using mice transplanted S180 tumor , the tumor-inhibiting activities was investigated .

脂多糖、白介素-6和肿瘤坏死因子α与三氟吡啦嗪（TFP）或1-（5-异喹啉磺胺）-3-甲基哌嗪（H7）联合运用，则它们的刺激作用受到明显抑制。

While LPS , IL-6 and TNF α were combined with trifluoperazine or H 7 , their inductive effects were inhibited .

水解动力学合成手性NAF的工艺考察及手性芳氧基哌嗪类化合物的合成、生物活性研究

The Synthesis Process Study of Chiral NAF Utilizing Hydrolytic Kinetic Resolution and Synthesis , Biological Evaluation of Chiral Aryloxy-Piperazine Derivatives

以N－β－羟乙基乙二胺为原料合成哌嗪，研制出一种高活性和选择性铜／载体型催化剂，并探讨了催化剂组成等因素对反应的影响。

This paper is concerned about the catalyst for the synthesis of piperazine with N (β hydroxyl ethyl ) ethylenediamine ( HEDA ) as raw material . A new supported copper catalyst with high reactivity and selectivity was developed .

初步药理实验表明，正丙胺羟丙哌嗪镇咳活性明显优于左羟丙哌嗪（LD），而其他胺基取代的目标化合物镇咳活性与左羟丙哌嗪（LD）相比无明显改变。

It was indicated that n-Propylamine dropropizine had greater effect on cough than LD , while the other compounds with Amino groups as substitutes had comparable activity with LD as antitussive .

方法以1-（4-硝基苯基）哌嗪为起始原料，经Boc保护、硝基还原、酰化、肼解、环合制得目标化合物。

Methods The product was synthesized from 1 - ( 4-nitrophenyl ) piperazine by Boc protection , reduction of nitro group , acylation , hydrazinolysis and cyclization .

报道了9种新合成的苄基哌嗪衍生物的13cNMR化学位移数据，在B3LYP/6-31g（d）水平上全优化计算了其量子化学结构参数。

~ ( 13 ) C NMR chemical shifts of nine new synthesized 1-benzyl-piperazine was reported . The electronic structures were completely optimized and calculated at B3LYP / 6-31g ( d ) level .

在本课题组的研究基础上，本文发展了以可溶性聚合物聚乙二醇（PEG4000）为支载体，合成了聚乙二醇支持的哌嗪作为Knoevenagel缩合反应的催化剂；

Under the previous research work of our workgroup , PEG-supported piperazine was synthesized as a Knoevenagel catalyst ;

7哌嗪8N喹诺酮酸具有[M-68]特征离子，可能是来自三氢重排的结果。

The [ M-68 ] fragment ion probably results from a rearrangement of three hydrogens .

方法用间氯苯哌嗪（mcpp）诱导产生焦虑，观察ddy小鼠和ICR小鼠在明暗箱的行为表现。

METHODS The behavior activity of ddy and ICR mice in light-dark box was observed after sc m-chlorophenylpiperazine ( m CPP ) to induce anxiety .

多沙唑嗪是一种抗高血压手性药物，1-（1,4-苯并二口恶烷-2-羰基）哌嗪（BCP）是合成该药物的重要手性中间体。

Doxazosin is a chiral antihypertensive drug . 1 - ( 1,4-Benzodioxane-2-carbonyl ) - piperazine ( BCP ) is an important chiral intermediate for the preparation of doxazosin .