依布硒

结果DSC分析表明，依布硒是以非晶体状态存在，用水溶性载体普朗尼克制备的分散体体外溶出60min大于60%。

RESULTS The DSC analysis suggested that ebselen was present in an amorphorous form in the solid dispersion . Ebselen solid dispersion was prepared with water-soluble carriers pluronic , released 60 % in 60 min.

依布硒及其类似物对大鼠血小板和腹腔白细胞脂氧合酶产物生成的影响

Effects of ebselen and its analogue on arachidonic acid metabolism via lipoxygenase in rat platelets and peritoneal leukocytes

通过对合成的产物进行急性经口毒性试验，发现其经口半数致死量（LD50，mediumlethaldose）大于5.5g/Kg，按照急性毒性分级标准确定该依布硒林衍生物属实际无毒级。

The oral acute toxicity test showed LD50 ( medium lethal dose ) > 5.5 g / Kg . Such result demonstrates that the synthesized product is nontoxic according to the classification of acute toxicity standard .

超氧阴离子对脑片谷氨酸释放的增强及依布硒的抑制

Glutamate release increased by superoxide anion radical and the protection of ebselen

结论：依布硒啉能保护肝损伤，可能与抗自由基的脂质过氧化有关。

CONCLUSION : The above results indicate that ebselen is effective against liver damage , which may derive from its anti lipid oxidation capacity .