高分化鳞癌

抗人尿道高分化鳞癌单抗E6及F9在上皮性肿瘤组织的表达及其意义

The expression and significance of E_6 and F_9 high in epithelioid tumour tissue

周期蛋白E在正常皮肤、鲍温病和皮肤鳞癌中的阳性表达率分别为8%、43.8%和63%，在高分化鳞癌和低分化鳞癌中的阳性表达率分别为62.5%和66.7%。

The positive expression rate of cyclin E in normal skin , Bowen 's disease , and squamous cell carcinoma was 8 % , 43.8 % and 63 % respectively .

结果：PTEN在正常皮肤、皮肤基底细胞瘤和鳞状细胞癌中的阳性表达率分别为100%、75%和37.5%，在高分化鳞癌和低分化鳞癌中的阳性表达率分别为41.76%和0。

Results The positive expression rate of PTEN in normal skin , basal cell carcinoma and squamous cell carcinoma was 100 % , 75 % and 37.5 % respectively .

方法利用ABC免疫组化技术观察60例肺鳞癌患者（高分化鳞癌40例，低分化鳞癌20例，其中28例淋巴结转移）癌细胞中MMP-2、MMP-9的表达情况。

Methods The ABC immunohistochemical method was used to observe the expression of MMP-2 , MMP-9 in 60 cases with lung squamous cell carcinoma ( 40 highly differentiated and 20 poorly differentiated ones ), among which there were 28 cases with lymph node metastasis .

结果：Cox-2及VEGF的表达从正常口腔黏膜到口腔白斑以至口腔鳞癌演变过程中不断增高，Cox-2在高分化鳞癌中表达量最高（0.167±0.004），随癌的分化程度降低而减少；

RESULTS : The expressions of Cox-2 and VEGF increased significantly as the progression of oral mucosa from normal to oral leukoplakia and oral SCC . The expression of Cox-2 reached peak in well differentiated SCC ( 0.167 ± 0.004 ), and its expression decreased sharply as differentiation became poor .

组织病理：高分化鳞癌（龟头皮损）；

Histopathology : well differentiated squamous cell carcinoma ( lesions at glans penis );

抗人尿道高分化鳞癌单克隆抗体的研制

Development of Monoclonal Antibodies of Highly Differentiated Squamous Cell Carcinoma in Epithelioid Tumour Tissue

其在喉癌中表达的阳性率在细胞不同分化程度中的差异有统计学意义，低分化鳞癌的表达强度高于高分化鳞癌；

The expression of p63 in squamous cell carcinomas with poor histological differentiation was higher than those of well differentiated .

87例中，低分化鳞癌62例，中等分化鳞癌11例，高分化鳞癌14例。

Of the 87 patients , 62 had poorly differentiated 11 moderate differentiated , and 14 well differentiated squamous cell carcinoma .

鼻咽癌的病理类型中低分化鳞癌最多见，占鼻咽癌的80%-85%；高分化鳞癌约占10%。

Low differentiated squamous cell carcinoma is about 80-85 % of NPC pathological types and well differentiated squamous cell carcinoma is 10 % .

好发年龄为：40-70岁。病理分型：高分化鳞癌：76例，占84.4%。

Diagnosed at the age : 40-70.Pathological type of which was well-differentiated squamous cell carcinoma were : 76 cases , accounting for 84.4 % .

方法：将子宫颈高分化鳞癌手术标本移植于裸鼠皮下，生长后，于鼠间连续传代，并检测移植瘤的相关生物学特征；

Methods : A human well differentiated cervical squamous cell carcinoma derived from a surgical specimen was transplanted in the subcutis of nude mice .

临床上，鼻咽癌98%是低分化鳞癌；高分化鳞癌、腺癌、泡状核细胞癌等较少见。

Clinically , Poorly-differentiated squamous cell carcinoma is present in 98 % NPC patients , well-differentiated squamous cell carcinoma and adenocarcinoma are rarely encountered .

组织学类型中低分化、中分化、高分化鳞癌，鳞腺癌、腺癌的淋巴结转移率分别为87.0%、34.0%、14.3%、57.1%和62.5%。

Rate of lymph nodes metastasis was 87.0 % , 34.0 % , 14.3 % , 57.1 % and 62.5 % respectively for low differentiation , middle differentiation , high squamous cell carcinoma , squamous - adenocarcinoma and adenocarcinoma .

12周时这两组动物颊囊病变呈高分化鳞癌，但所有动物颈淋巴结及脏器（肺、肝、脾等）检查无异常发现。

The high differentiated squamous cell carcinoma could be seen in group ⅰ and group ⅱ after 12 weeks , but no abnormal changes in cervical lymphnodes and organs ( lung , liver , spleen , et al ) of all animals in 4 groups .

且VEGF-C蛋白的表达在有淋巴结转移的喉鳞癌组织中明显高于无淋巴结转移组织，在低分化喉鳞癌组织中的表达明显高于高、中分化喉鳞癌组织。

Furthermore , the expression of VEGF-C in laryngeal squamous carcinoma cells was significantly higher in lymph-node-positive groups than in node-negative groups , and the expression was significantly higher in poorly differentiated LSC tissues than in moderately and well differentiated LSC tissues .