青霉胺

青霉胺和美满霉素则有清除·OH的作用。

Penicillamine and minocycline had an effect of scavenging · OH .

将所得膜剂进行表观性状观察、厚度测量并检测其中的青霉胺（PA）含量，对上述材料进行初步筛选；

Then we measure the thickness , observe the appearance and the dissolvable time , detect the penicillamine content of the membrane .

用pH滴定法测定镉与D-青霉胺螯合物稳定常数。

The stability constant of the cadmium-D-penicillamine chelate is determined by the pH metric method .

D-青霉胺（DPA）为青霉素的代谢产物，系含有巯基的氨基酸，对汞具有较强的络合作用。

D-penicillamine ( DPA ) is the metabolic product of penicillin and belongs to the a-mino acid that contains the thiol .

观察和比较青霉胺、氨苯砜、氯喹、四环素、美满霉素和灭滴灵对PMN产生ROS和非细胞体系的和·OH的影响。

We investigated the effects of penicillamine , chloroquine , dapsone , metronidazole , tetracycline and minocycline on ROS generated by PMNs and O ,· OH generated in the cell-free system .

结果提示，青霉胺、氯喹、美满霉素、灭滴灵、氨苯砜和四环素具有抑制或清除PMN产生的ROS；

The results showed that penicillamine , chloroquine , minocycline , dapsone , tetracycline and metronidazole had an effect of inhibiting or scavenging ROS generated in PMNs ;

结论大剂量硫酸锌与小剂量青霉胺联合应用治疗儿童HLD效果可靠，价格低廉，副作用小。

Conclusion Combined therapy of large dose zinc sulfate and low dose penicillamine is an effective , safe and cheap treatment for children with HLD .

方法采用染色体分析技术对对照组、硫酸锌组、青霉胺组、（硫酸锌+青霉胺）组的SCE频率进行观察。

Methods : Chromosome analysis technique was used to observe SCE frequencies in cultured lymphocyte of contro ⅰ group , zinc sulphate group , penicillamine group and zinc sulphate + penicillamine group .

为了解青霉胺对缺血后再灌注心肌损伤的影响，我们采用Langendrof离体大鼠心脏灌注模型，先灌注15min后停止灌注，模拟缺血60min，然后再灌注60min。

To investigate the effects of penicillamine on postischemic myocardial reperfusion injury , we used Langendorff isolated rat heart as the experimental model in this study .

在H2SO4介质中，Fe（Ⅲ）能催化H2O2与甲基红之间的褪色反应；加入青霉胺后，青霉胺又能灵敏地阻抑该氧化褪色反应，从而建立青霉胺的测定方法。

A new method for the determination of Penicillamine was proposed . It was based on the inhibitory effect of penicillamine on discoloring reaction of H_2O_2 and methyl red catalyzed by Fe ~ ( 3 + ) in dilute sulfuric acid solution .

目的提高临床医生对青霉胺（D-PA）致肾病综合征和重症肌无力的认识。

Objective To improve clinicians'understanding of nephrotic syndrome and myasthenia gravis as adverse events of penicillamine ( D-PA ) .

结果苯肾上腺素刺激诱发的平滑肌细胞钙调磷酸酶的表达和活性可被一氧化氮供体S-亚硝基-N-乙酰青霉胺和Sp-8-pCPT-cGMP抑制，但可被Rp-8-pCPT-cGMP增强。

Results The results showed that phenylephrine ( PE ) - induced expression and activity of CaN protein was reduced by S-nitroso-N-acetylpenicillamine ( SNAP ) and Sp-8-pCPT-cGMP , but increased by Rp-8-pCPT-cGMP .

经0.5mg/L环孢素A预处理后，苯肾上腺素刺激诱发的平滑肌细胞吸光度降低36.67%，S-亚硝基-N-乙酰青霉胺、Sp-8-pCPT-cGMP或Rp-8-pCPT-cGMP并不能进一步抑制或升高已升高的吸光度。

In SMC pretreated with CsA , absorbance of cells stimulated by PE decreased by 36.67 % , but it could not be further altered by the additional treatment of SNAP , Sp-8-pCPT-cGMP and Rp-8-pCPT-cGMP .

川芎嗪和青霉胺对大鼠慢性实验性肺动脉高压的影响

Effects of Ligustrazine and penicillamine on chronic experimental pulmonary hypertension in rats

二巯基丙磺酸钠和青霉胺治疗肝豆状核变性的驱铜效果对比分析

Comparison of effects of DMPS and penicillamine on decoppering therapy of hepatolenticular degeneration

目的：观察青霉胺预防腹腔粘连的疗效。

Objective : To study the effect of penicillamine on preventing intraperitoneal adhesion formation .

在用青霉胺治疗肝豆核变性期间，出现匍行性穿通性弹性组织变性与弹性假黄瘤病

Elastosis perforans serpiginosa associated with pseudo-pseudoxanthoma elasticum during treatment of wilson 's disease with penicillamine

青霉胺致肾病综合征重症肌无力二例并文献复习

D-Penicillamine induced nephrotic syndrome and myasthenia gravis : two cases report and review of literature

D-青霉胺酰化消旋工艺及动力学研究

Acetylized Racemization Process and Kinetics of D-penicillamine

肝豆状核变性患者青霉胺治疗期间尿中多种元素分析

Analysis of multiple elements in urine of patients with Wilson 's disease during penicillamine therapy

目的探讨青霉胺治疗肝豆状核变性的最佳方案。

Objective To determine the best plan with penicillamine in treating the patients with hepatolenticular degeneration .

目的研究D-青霉胺在酸性条件下进行酰化外消旋的工艺。

OBJECTIVE : To study the process of acetylized racemization of D-penicillamine in the acidic condition .

D-青霉胺的制备

Preparation of D - penicillamine

目的探讨抗硬化复方与青霉胺对硬皮病小鼠模型的影响。

Objective To explore the effect of Antisclerosis Composite Prescription ( ACP ) and penicillamine on scleroderma mouse .

镨（Ⅲ）溶液光谱研究：高氯酸镨&谷氨酸／苦杏仁酸／青霉胺配合物

Spectral studies of praseodymium in the solution ; complexes of glutamic acid , mandelic acid and penicillamine with praseodymium

间接炙与青霉胺在Ⅱ型胶原诱导的大鼠关节炎模型中的病理观察

Pathological Observation of the Effect of Indirect Moxibustion and Penicillamine on Arthritis Induced by Type ⅱ Collagen in Rats

大剂量硫酸锌与小剂量青霉胺联合治疗儿童肝豆状核变性长期随访

Long Term Follow up of Combined Therapy with Large dose Zinc Sulfate and Low Dose Penicillamine in Children with Hepatolenticular Degeneration

2方法有症状病儿初期用小剂量青霉胺并大剂量硫酸锌联合治疗；

Methods Children with clinical symptoms were treated with large-dose of zinc sulfate and low dose of penicillamine at the beginning of treatment .

方法以D-青霉胺为原料，在醋酸溶液中，用乙酰氯为酰化试剂进行消旋化，得到了D-青霉胺酰化消旋物；

METHODS : The acetylized racemic mixture of D-penicillamine was prepared by racemizing acetyl chloride in acetic acid solu_tion with D-penicillamine as feedstock .

本文用青霉胺治疗11例硬皮病。9例局限型、2例肢端型。

The excellent response to systmic penicillamine in treating 11 patients with scleroderma ( 9 scleroderma circumscriptum and 2 acrosclerosis ) was reported .